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General Clinical Research Center
Duke University Medical Center
Box 3854
Durham, NC 27710
URL: http://igg1.mc.duke.edu/gaveston/
Grant No. M01 RR00030
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Elaine Campbell, M.A.
919-668-2253; Fax: 919-681-8829
E-mail: campb066@mc.duke.edu
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Program Director
M. Louise Markert, M.D., Ph.D.
919-684-6263; Fax: 919-681-8676
E-mail: marke001@mc.duke.edu
Principal Investigator
R. Sanders Williams, M.D.
919-684-2455; Fax: 919-684-0208
E-mail: willi397@mc.duke.edu
Associate Program Director
Christopher Coughlin, M.D.
919-668-5643; Fax: 919-681-8829
E-mail: coughlin@radonc.duke.edu
Research Subject Advocate
Wajeeh Bajwa, Ph.D.
919-684-2347; Fax: 919-684-5041
E-mail: bajwa001@mc.duke.edu
Nurse Manager
Lynn Dudka, B.S.
919-668-2260; Fax: 919-684-5041
E-mail: dudka001@mc.duke.edu
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Bionutrition Manager
Elise Pangborn, R.D., L.D.N., C.D.E.
919-668-2251; Fax: 919-684-5041
E-mail: pangb001@mc.duke.edu
Biostatistician
Elizabeth Hauser, Ph.D.
919-402-2557; Fax: 919-401-0166
E-mail: bhauser@chg.mc.duke.edu
Biostatistician
Steven C. Grambow, Ph.D.
919-286-6936; Fax: 919-416-5836
E-mail: gramb001@mc.duke.edu
Bioinformatics Manager
Jon Sullivan
919-684-5543; Fax: 919-684-5041
E-mail: sulli027@mc.duke.edu
Core Laboratory Director
E. William St. Clair, M.D.
919-684-4499; Fax: 919-684-8358
E-mail: stcla003@mc.duke.ed
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Anesthesiology: Neurologic outcome after coronary
bypass surgery.
Endocrinology: Type 2 diabetes in adolescents; mechanisms
of obesity in Prader-Willi.
Geriatric Medicine: Vascular depression.
Nephrology: Immunosuppression after kidney transplantation.
Obstetrics: Smoking cessation in pregnancy.
Oncology: Diet and cancer; chemotherapy.
Pediatrics: Glycogen storage diseases; lymphocyte receptors and
responses in immunodeficiency; thymic transplantation in DiGeorge
syndrome; treatment for Down syndrome; food allergy.
Psychiatry: Behavior and cardiovascular disease; race,
dietary sodium, and cardiovascular responses to stress;
epidemiology of successful aging; exercise and hypertension;
smoking cessation; exercise and depression.
Pulmonary Medicine: Genetics of asthma.
Rheumatology: Genetics of rheumatoid arthritis; antiphospholipid
antibody syndromes; therapies in rheumatoid arthritis; genetics of
osteoarthritis.
Surgery: Dendritic cell vaccines for cancer.
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General Clinical Research Center
Memorial Hospital, Campus Box #7600
University of North Carolina School of Medicine
Chapel Hill, NC 27599-7600
URL: http://verne.med.unc.edu
Grant No. M01 RR00046
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Mary Beth Lister, M.P.H.
919-966-4767; Fax: 919-966-1576
E-mail: mblister@med.unc.edu
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Program Director
Paul B. Watkins, M.D.
919-966-1435; Fax: 919-966-1576
E-mail: pbwatkins@med.unc.edu
Principal Investigator
Eugene P. Orringer, M.D.
919-966-4161; Fax: 919-966-7564
E-mail: epo@med.unc.edu
Associate Program Director
Michael Fried, M.D.
919-966-2516; Fax: 919-966-1700BR>
E-mail: mfried@med.unc.edu
Associate Program Director
Joseph J. Eron Jr., M.D.
919-966-2536; Fax: 919-966-6714
E-mail: jeron@med.unc.edu
Core Laboratory Director
Gary Pollack, Ph.D.
919-966-9989; Fax: 919-966-9650
E-mail: gary_pollack@unc.edu
Research Subject Advocate, Epidemiologist
David J. Weber, M.D., M.P.H.
919-966-2536; Fax: 919-966-1576
E-mail: DWeber@unch.unc.edu
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Research Subject Advocate
Marie Zeldin, R.N., B.S.N.
919-966-6844; Fax: 919-966-1576
E-mail: mzeldin@med.unc.edu
Nurse Manager
Nancy Cozart, M.P.A., R.N.
919-966-4744; Fax: 919-966-1576
E-mail: ncozart@med.unc.edu
Training and Career Development
Susan Pusek, M.P.A.
919-966-0128; Fax: 919-966-1576
E-mail: suspusek@med.unc.edu
Nutrition Research Manager
Marjorie Busby, M.P.H., R.D.
919-966-4746; Fax: 919-966-1576
E-mail: mgbusb@med.unc.edu
Biostatistician
Paul W. Stewart, Ph.D.
919-966-7276; Fax: 919-966-3804
E-mail: paul_stewart@unc.edu
Computer Systems Manager
Clarence Potter, M.S.
919-966-4802; Fax: 919-966-1576
E-mail: cpotter@med.unc.edu
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Special Assays, Services, or Tests
Detailed dietary analysis (calories, protein,
carbohydrates, fats, Na, K, Ca, PO4), choline, d-chiro
inositol
ELISA core lab
Plasma and urine catecholamines
Special Resources, Instruments, or Services
Body composition laboratory–DEXA, indirect
calorimeter, bioelectrical impedance analysis (BIA), anthropometrics
HPLC
HPLC electrospray mass spectrometer
Human applications laboratory
Pulmonary function lab for children and adults
Treadmill exercise EKG, metabolic monitoring
Cardiology: Noninvasive evaluation of cardioactive
drugs; neurohumoral factors in heart failure; therapy of
hypercholesterolemia.
Cystic Fibrosis: Development and testing of novel
therapeutic approaches, including aerosolized amiloride and
adenine nucleotides; gene therapy; role of atypical
mycobacterial infection.
Dentistry: Role of oral inflammation in systemic diseases.
Dermatology: Pathogenesis of epidermolysis bullosa,
bullous pemphigoid, and other bullous skin diseases.
Endocrinology: Growth hormone and insulin-like
growth factors (IGF) in pituitary disorders;
nutritional regulation of IGF and IGF-binding protein
production; growth hormone therapy of short but
GH-sufficient children; use of GH in obese subjects;
diagnostic test evaluation in Cushing's syndrome;
regulation of TSH secretion; GH and IGF-I in HIV.
Gastroenterology: Therapy of inflammatory bowel
disease; localization of intestinal sites of drug
absorption; case-control study of colonic tumor patients;
hepatitis B and C therapy; Norwalk virus challenge; drug-induced liver
disease.
Gynecology: Molecular predictors of natural history of
uterine fibroids; gynecologic oncology group treatment protocols
for cancer of the ovary, uterus, and fallopian tubes.
Hematology and Oncology: Gene therapy for hemophilia; novel
therapies for sickle cell anemia; proteosome inhibitors in the
treatment of hematological and solid malignancies; molecular
predictors of tumor response to treatments; adoptive
immunotherapy of malignancies.
HIV and AIDS: Treatment for HIV-1 infection with antiretroviral
compounds and immune modulators including IL-2 and thalidomide;
treatment for AIDS-related opportunistic infections including
Pneumocystis carinii pneumonia, Mycobacterium-avium
intracellulare, aphthous ulcers, particularly cytomegalovirus infections
and cryptococcal infections; therapy of HIV-1 including treatment with
protease inhibitors and nonnucleoside compounds; treatment of membrane
attack complex, resistant herpes simplex virus infections, and
cryptococcal meningitis; treatment of pediatric HIV-1 infection and AIDS,
including therapeutic protocols and other nucleoside analogues; evaluation
of therapies to prevent HIV-1 transmission from seropositive pregnant
women to their infants; treatment of HIV-1-related malignancies; neurologic
consequences of HIV-1 infection; psychiatric and social impact of
HIV-1 infection and of HIV-1 high-risk behavior, especially in men
who have sex with men; pharmacokinetic studies of medications used
in treatment of HIV and HIV-related opportunistic infections.
Infectious Diseases: Hepatitis infection in hemophiliacs;
sexually transmitted diseases, including studies in gonorrheal
pathogenesis and vaccine development; antifungal therapy in the
immunocompromised host.
Neurology: Sensory-evoked potential changes in
nervous system dysfunction and anticonvulsant drug
withdrawal; evaluation of new anticonvulsant drugs;
evaluation of CNS function in HIV-positive patients.
Pharmacology: Molecular determinants of drug disposition;
use of probe drugs to determine drug metabolism enzyme/transporter
phenotype.
Psychiatry: Neurohumoral effects of chlorimipramine
and oxytocin; antidepressant drug effects in noradrenergic
and serotoninergic systems; renal and cardiovascular
effects of psychological stress; coping in patients with
HIV infection; postpartum depression; coping in sickle cell
disease.
Pulmonary Disorders: Pathophysiology of reactive
airways disease; treatment of asthma.
Surgery: Chemotherapy of brain tumor following
surgery; active immunotherapy for anaplastic gliomas.
Women's Health: Hormone replacement therapy; dietary
modification; calcium and vitamin D supplementation; factors
involved in preterm birth.
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General Clinical Research Center
Wake Forest University School of Medicine
Medical Center Boulevard
Winston-Salem, NC 27157
URL: http://gcrc.wfubmc.edu
Grant No. M01 RR07122
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Diane Q. Mann, M.S.
336-716-2785; Fax: 336-716-5055
E-mail: dqmann@wfubmc.edu
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Program Director
Charles E. McCall, M.D.
336-716-4584; Fax: 336-716-3825
E-mail: chmcall@wfubmc.edu
Principal Investigator
William B. Applegate, M.D.
336-716-3430; Fax: 336-716-5139
E-mail: wapplega@wfubmc.edu
Associate Program Director
John R. Crouse III, M.D.
336-716-2076; Fax: 336-716-6164
E-mail: jrcrouse@wfubmc.edu
Associate Program Director
Richard B. Weinberg, M.D.
336-716-4638; Fax: 336-716-6376
E-mail: weinberg@wfubmc.edu
Associate Program Director
Jeff D. Williamson, M.D.
336-713-8583; Fax: 336-713-8800
E-mail: jwilliam@wfubmc.edu
Research Subject Advocate
Susan Margitic, M.S.
336-716-5647; Fax: 336-716-0395
E-mail: smargitic@wfubmc.edu
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Research Nurse Manager
Marcy Poletti, R.N., M.S.N.
336-716-9755; Fax: 336-716-5055
E-mail: mpoletti@wfubmc.edu
Bionutrition Research Manager
Linda Easter, R.D., M.S., L.D.N.
336-716-6355; Fax: 336-716-5055
E-mail: leaster@wfubmc.edu
Processing Lab Manager
Marcia Burris
336-716-2676; Fax: 336-716-5055
E-mail: mburris@wfubmc.edu
Molecular Genetics Core Director
Donald W. Bowden, Ph.D.
336-713-7507; Fax: 336-716-5055
E-mail: dbowden@wfubmc.edu
Biostatistician
Timothy Morgan, Ph.D.
336-713-3829; Fax: 336-713-3806
E-mail: tomorgan@wfubmc.edu
Informatics Core Manager
Robert Amoroso
336-716-7786; Fax: 336-716-5055
E-mail: bamoroso@wfubmc.edu
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Special Resources, Instruments, or Services
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Ankle and brachial blood pressure indices
Anthropometry
Bronchoscopy
Chemotherapy
Clinical breast exams
Cognitive testing
Computerized diet planning for balanced, constant and
weighed diets
Conscious sedation
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Food frequency administration and analysis
Geriatric GCRC
Hewlett-Packard monitor for blood pressure, respiration,
pulse oximetry and cardiac rhythms
Intravenous and oral glucose tolerance testing
Metabolic research kitchen
Nutrition data system for research
Nutrition education
Stress testing
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Anesthesiology: New spinal anesthetic agents for
childbirth and chronic pain.
Cardiovascular Diseases: Treatments for peripheral arterial
disease; hypertension and salt sensitivity; exercise training and
congestive heart failure; multiethnic study of atherosclerosis;
ACE inhibition and novel cardiovascular risk factors; diastolic
heart failure.
Dermatology: Psoriasis; reinforcing properties of UV
light in tanning bed users.
Endocrinology: Diabetes prevention trial; inhaled
insulin versus subcutaneous insulin therapy in diabetes;
LDL cholesterol-lowering drugs in hypercholesterolemia.
Gastroenterology: Responses to dietary fat and
cholesterol; oxalate studies; virtual colonoscopy.
Genetics: Genetic epidemiology of diabetic
cardiovascular disease; molecular epidemiology of breast
cancer and prostate cancer; genes and chronic obstructive pulmonary
disease; genetics of bone in type 2 diabetes.
Geriatrics and Gerontology: Arthritis, diet, and activity
promotion; depression in the elderly; resistance training in older
adults; diet, exercise, and metabolism in older women.
Hematology and Oncology: Prostate cancer prevention;
diphtheria fusion toxin therapy of myeloid leukemia; recovery in
breast cancer; chemotherapy-induced cardiomyopathy and MRI.
Infectious Diseases: Cellular mechanisms of septic
shock.
Nephrology: Hemodialysis and quality of life; progression
of renovascular disease in the elderly.
Neurology: Treatment of chronic inflammatory demyelinating
polyneuropathy; amyotrophic lateral sclerosis; Huntington's disease.
Obstetrics and Gynecology: Ovarian cancer screening study;
fatty acids and preterm birth; folic acid load in pregnant
epileptic women.
Pediatrics: Ventilation in very-low-birthweight infants;
cystic fibrosis, sinusitis; bone strength in children; effect of
postnatal dexamethasone on children at school age.
Physiology and Pharmacology: Regional brain activation
during cocaine abstinence.
Psychiatry: Optimization of electroconvulsive
therapy for depression.
Pulmonary Diseases: Lipid pathways and lung injury;
asthma studies; lung cancer screening.
Rheumatology: Systemic lupus erythematosus; T cells.
Urology: Role of oxalate in nephrolithiasis.
Women's Health: Women's Health Initiative (WHI); WHI memory study
(WHIMS).
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