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Autologous Incubated Macrophages for Patients with Complete Spinal Cord Injuries
This study is currently recruiting patients.
Sponsored by: | Proneuron Biotechnologies |
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Information provided by: | Proneuron Biotechnologies |
Purpose
Autologous Incubated Macrophages (ProCord) is being developed as a therapy for acute, complete spinal cord injury (SCI). The therapy is intended to reverse the loss of motor and sensory function.
Following non-CNS tissue injury, macrophages quickly arrive on the scene, where they clean up cell debris, secrete different molecules thus promoting a controlled inflammatory reaction that forms the first phase of the wound healing process. While this process occurs in most tissues, including peripheral nerves, it does not occur in the CNS, where macrophages and other immune cells are relatively rare, and their activities curtailed by a biochemical mechanism known as “immune privilege.”
In animal studies, it appears that incubated macrophagescircumvent the immune privilege, thus supporting the regrowth of axons through the injury site and enabling the recovery of neurological function. The concept derives from the pioneering research of Prof. Michal Schwartz at the Weizmann Institute of Science.
Condition | Treatment or Intervention | Phase |
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Spinal Cord Injury |
Procedure: Autologous Incubated Macrophages (cell therapy) |
Phase II |
MedlinePlus related topics: Spinal Cord Injuries
Study Type: Interventional
Study Design: Treatment, Randomized, Open Label, Active Control, Single Group Assignment, Safety/Efficacy Study
Official Title: A Phase II Multicenter, Randomized-Controlled Study to Evaluate the Safety and Efficacy of Autologous Incubated Macrophages for the Treatment of Patients with Complete Spinal Cord Injuries
Expected Total Enrollment: 61
Study start: December 2003
Eligibility
Ages Eligible for Study: 16 Years - 65 Years, Genders Eligible for Study: Both
Criteria
Inclusion Criteria:
Exclusion Criteria:
Location and Contact Information
More Information
Spinal Cord Injuries - Patient, Physician and Contact information
U.S. National Library of Medicine, Contact NLM Customer Service | ||||||||||||||
National Institutes of Health, Department of Health & Human Services | ||||||||||||||
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