By Congressional mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) produces "toxicological profiles" for hazardous substances found at National Priorities List (NPL) sites. These hazardous substances are ranked based on frequency of occurrence at NPL sites, toxicity, and potential for human exposure. Toxicological profiles are developed from a priority list of 275 substances. ATSDR also prepares toxicological profiles for the Department of Defense (DOD) and the Department of Energy (DOE) on substances related to federal sites.

So far, 275 toxicological profiles have been published or are under development as "finals" or "drafts for public comment"; 250 profiles were published as finals; 106 profiles have been updated. Currently, 18 profiles are being revised based on public comments received and 7 profiles are being developed as public comment draft. These profiles cover more than 250 substances.

Toxicological profiles are developed in two stages:

(1) DRAFTS: The toxicological profiles are first produced as drafts. ATSDR announces in the Federal Register the release of these draft profiles for a 90 day public comment period. Request draft toxicological profiles from ATSDR's Division of Toxicology.

(2) FINALS: After the 90 day comment period, ATSDR considers incorporating all comments into the documents. ATSDR finalizes the profiles and the National Technical Information Service (NTIS) distributes them.

ATSDR's toxicological mailing list

Congress requires ATSDR (1) to provide toxicological profiles to state health and environmental agencies and (2) to make them available to other interested parties. The Division of Toxicology (DT) has a mailing list, which is updated and verified yearly, of groups and individuals who get free copies of both draft and final profiles; these include health professionals at federal, state, and local levels; academicians; nonprofit/environmental groups; members of the public involved with Superfund sites; and parties with special needs (considered case-by-case).

If you don=t qualify for free copies, you may request final profiles from NTIS for a fee.

NTIS distributes finalized toxicological profiles for a fee. For more information, contact:

National Technical Information Service 
5285 Port Royal Road
Springfield, Virginia 22161
1-800-553 6847 or 703-605-6000
Web site: http://www.ntis.gov

Additional Resources:

• ATSDR ToxProfiles 2003™ CD-ROM - The toxicological profiles are also available as a complete set on CD-ROM.
• Public Health Statements (PHS) - The PHS are a series of summaries about hazardous substances taken from Chapter One of their respective ATSDR Toxicological Profiles.
• ATSDR ToxFAQs™ - The ToxFAQs™ are a series of 2-page fact sheets about hazardous substances.
  

To request a copy of the ToxProfiles™ CD-ROM, PHS, or ToxFAQsTM call 404-498-0261 or email your request to atsdric@cdc.gov.

For more information on the above listed publications, write

Division of Toxicology, Agency for Toxic Substances and Disease Registry
1600 Clifton Road, Mailstop F-32, Atlanta, GA 30333

For more information 24 hours/day

You may call the ATSDR toll free number at 1-888-42-ATSDR (1-888-422-8737) to get 24-hour recorded information about Division of Toxicology programs. This phone number includes options to be transferred to ATSDR personnel for technical assistance.

ATSDR Internet home page via World Wide Web: http://www.atsdr.cdc.gov

The profiles, public health statements, ToxFAQs™ and other information are available on the Internet.

Finalized toxicological profiles by chemical with NTIS order number (Updates are in bold. Asterisks denote tox profiles funded by the Department of Defense)

-A-

• Acetone      (PB/95/100095/AS)
• Acrolein      (PB/91/180307/AS)
• Acrylonitrile      (PB/91/180489/AS)
• Aldrin/Dieldrin      (Update) (PB2003-100134)
• Aluminum      (Update) (PB/99/166613)
• Ammonia      (PB/91/180315/AS)
• Antimony      (PB/93/110641/AS)
• Arsenic      (Update) (PB/2000/108021)
• Asbestos      (Update) (PB/2001/109101)
• Atrazine (PB2004-100001)
• Automotive gasoline      (PB/95/264206/AS) *

• Barium      (PB/93/110658/AS)
• Benzene      (Update) (PB/98/101157/AS)
• Benzidine      (Update) (PB/2001/109102)
• Benzo(a)anthracene      (PB/90/247669/AS)
• Benzo(a)pyrene      (PB/90/258245/AS)
• Benzo(b)fluoranthene      (PB/90/247651/AS)
• 2,3-Benzofuran      (PB/93/110666/AS)
• Beryllium     (Update) (PB2003-100135)
• Bis(2-chloroethyl)ether      (PB/90/168683/AS)
• Bis(chloromethyl)ether      (PB/90/168691/AS)
• Boron      (PB/93/110674/AS)
• Bromodichloromethane      (PB/90/167461/AS)
• Bromoform      (PB/91/180323/AS)
• Bromomethane      (PB/93/110682/AS)
• 1,3-Butadiene      (PB/93/110690/AS)
• 2-Butanone      (PB/93/110708/AS)
• 2-Butoxyethanol & 2-Butoxyethanol acetate      (PB/99/102527/AS)*

• Cadmium      (Update) (PB/99/166621)
• Carbon disulfide      (Update) (PB/97/121073/AS)
• Carbon tetrachloride      (Update) (PB/95/100103/AS)
• Chlordane      (Update) (PB/95/100111/AS)
• Chlorfenvinphos      (PB/98/101116/AS)
• Chlorinated Dibenzo-p-dioxins     (Update) (PB/99/121998)
• Chlorobenzene      (PB/91/180505/AS)
• Chlorodibenzofurans      (PB/95/100129/AS)
• Chlorodibromomethane      (PB/91/180323/AS)
• Chloroethane      (Update) (PB/99/121956)
• Chloroform      (Update) (PB/98/101140/AS)
• Chloromethane      (Update) (PB/99/121964)
• Chlorophenols      (Update) (PB/99/166639)
• Chlorpyrifos      (PB/98/103088/AS)
• Chromium      (Update) (PB/2000/108022)
• Chrysene      PB/90/247644/AS)
• Cobalt      (PB/93/110724/AS)
• Copper      (PB/91/180513/AS)
• Creosote      (Update) (PB2003-100136)
• Cresols      (PB/93/110732/AS)
• Cyanide      (Update) (PB/98/101207/AS)

• 4,4'-DDT, DDE,DDD      (Update) (PB2003-100137)
• Diazinon      (PB/97/121107/AS)
• Dibenzo(a,h)anthracene      (PB/90/247636/AS)
• Dibromochloropropane      (PB/93/110906/AS)
• 1,2-Dibromoethane      (PB/93/110740/AS)
• 1,4-Dichlorobenzene      (Update) (PB/99/121972)
• 3,3'-Dichlorobenzidine      (Update) (PB/99/121980)
• 1,1-Dichloroethane      (PB/91/180539/AS)
• 1,2-Dichloroethane      (Update) (PB/2001/109103/AS)
• 1,1-Dichloroethene      (Update) (PB/95/100152/AS)
• cis-, trans- 1,2-Dichloroethene      (Update)(PB/97/121081/AS)
• 2,4-Dichlorophenol      (PB/93/110757/AS)
• 1,2-Dichloropropane      (PB/90/182122/AS)
• 1,3-Dichloropropene      (PB/93/110765/AS)
• Dichlorvos      (PB/98/101124/AS)
• Di(2-ethylhexyl)phthalate      (Update) (PB2003-100138)
• Diethyl phthalate      (PB/95/264214/AS) *
• Diisopropylmethylphosphonate      (PB/99/102535/AS) *
• Di-n-butyl phthalate  (Update) (PB/2001/109104/AS)
• 1,3-Dinitrobenzene/1,3,5-Trinitrobenzene      (PB/95/264289/AS)*
• Dinitrocresols      (PB/95/264321)
• Dinitrophenols      (PB/95/264339)
• 2,4- & 2,6-Dinitrotoluene      (Update) (PB/99/122004)
• Di-n-octylphthalate      (PB/98/101033/AS) *
• Dioxin      (Update)  See Chlorinated Dibenzo-p-dioxins
• 1,2-Diphenylhydrazine      (PB/91/180356/AS)
• Disulfoton      (PB/95/264347)

• Endosulfan      (Update) (PB/2000/108023)
• Endrin and Endrin aldehyde      (Update) (PB/97/121040/AS)
• Ethion      (PB/2000/108024)
• Ethylbenzene  (Update) (PB/99/166647)
• Ethylene glycol and Propylene glycol      (PB/98/101108/AS)*
• Ethylene oxide      (PB/91/180554/AS)

• Fluoride, Hydrogen Fluoride, and Fluorine (Update) (PB2004-100002)
• Formaldehyde      (PB/99/166654)
• Fuel oils      (PB/95/264222/AS) *

          None Available 

-H-

• Heptachlor/Heptachlor epoxide      (Update) (PB/93/182467/AS)
• Hexachlorobenzene      (Update) (PB2003-100139)
• Hexachlorobutadiene      (PB/95/100160/AS)
• Hexachlorocyclohexanes      (Update) (PB/99/166662)
• Hexachlorocyclopentadiene      (PB/99/166670)
• Hexachloroethane      (PB/98/101041/AS) *
• Hexamethylene diisocyanate      (PB/99/102543/AS) *
• Hexane      (PB/99/166688)
• 2-Hexanone      (PB/93/110773/AS)
• HMX      (PB/98/101058/AS) *
• Hydraulic fluids      (PB/98/101066/AS) *
• Hydrazines      (PB/98/101025/AS) *
• Hydrogen sulfide      (PB/99/166696)

• Ionizing Radiation      (PB/99/163388)
• Isophorone      (PB/90/180225/AS)

• Jet fuels - JP-4 & JP-7      (PB/95/264230/AS)*
• Jet fuels - JP-5 & JP-8      (PB/99/102550/AS)*

          None Available 

-L-

• Lead     (Update) (PB/99/166704)

• Malathion (PB2004-100003)
• Manganese     (Update) (PB/2000/108025)
• MBOCA     (PB/95/100186/AS)
• Mercury     (Update) (PB/99/142416)
• Methoxychlor     (Update) (PB2003-100140)
• Methylene chloride     (Update) (PB/2000/108026)
• Methylenedianiline     (PB/99/102568/AS) *
• Methyl mercaptan     (PB/93/110799/AS)
• Methyl parathion    (Update) (PB/2001/109105/AS)
• Methyl t-butyl ether     (PB/97/121016/AS)
• Mineral-based crankcase oil     (PB/98/101074/AS) *
• Mirex and Chlordecone     (PB/95/264354)
• Mustard gas     (PB/93/110815/AS)

• Naphthalene/1-methylnaphthalene/2-methylnaphthalene     (Update) (PB/95/264362)
• Nickel     (Update) (PB/98/101199/AS)
• Nitrobenzene     (PB/91/180398/AS)
• Nitrophenol     (PB/93/110823/AS)
• N-Nitrosodimethylamine     (PB/90/182130/AS)
• N-Nitrosodi-n-propylamine     (PB/90/180258/AS)
• N-Nitrosodiphenylamine     (Update) (PB/93/182509/AS)

• Otto fuel II     (PB/95/264248/AS) *

• Pentachlorophenol     (Update) (PB/2001/109106/AS)
• Phenol     (Update) (PB/99/122012)
• Plutonium     (PB/91/180406/AS)
• Polybrominated biphenyls     (PB/95/264388)
• Polychlorinated biphenyls:    Aroclors -1260,-1254, -1248, -1242, -1232, -1221, and -1016 (Update) (PB/2000/108027)
• Polycyclic aromatic hydrocarbons:    Acenaphthene, Acenaphthylene, Anthracene, Benzo(a)anthracene, Benzo(a)pyrene,  Benzo(b)fluoranthene, Benzo(g,h,i)perylene, Benzo(k)fluoranthene, Chrysene, Dibenzo(a,h)anthracene, Fluoranthene, Fluorene, Indeno(1,2,3-cd)pyrene, Phenanthrene, Pyrene (Update) (PB/95/264370)
• Pyrethrins and Pyrethroids (PB2004-100004)
• Pyridine     (PB/93/110831/AS)

          None Available 

-R-

• Radium     (PB/91/180414/AS)
• Radon     (PB/91/180422/AS)
• RDX     (PB/95/264255) *

• Selenium (Update) (PB2004-100005)
• Silver     (PB/91/180430/AS)
• Stoddard solvent     (PB/95/264263) *
• Styrene     (PB/93/110849/AS)
• Sulfur Dioxide     (PB/99/122020)
• Sulfur Mustard (Update) (PB2004-100006)
• Sulfur Trioxide/Sulfuric Acid     (PB/99/122038)

• 2,3,7,8-Tetrachlorodibenzo-p-dioxin     (PB/89/214522/AS)
• 1,1,2,2-Tetrachloroethane     (Update) (PB/97/121099/AS)
• Tetrachloroethylene     (Update) (PB/98/101181/AS)
• Tetryl     (PB/95/264271/AS) *
• Thallium     (PB/93/110856/AS)
• Thorium     (PB/91/180448/AS)
• Tin     (PB/93/110864/AS)
• Titanium tetrachloride     (PB/98/101082/AS) *
• Toluene     (Update) (PB/2000/108028)
• Toxaphene     (Update) (PB/97/121057/AS)
• Total Petroleum Hydrocarbons     (PB/99/163370) *
• 1,1,1-Trichloroethane     (Update) (PB/95/264396)
• 1,1,2-Trichloroethane     (PB/90/196411/AS)
• Trichloroethylene     (Update) (PB/98/101165/AS)
• 2,4,6-Trichlorophenol     (PB/91/181545/AS)
• 1,2,3-Trichloropropane     (PB/93/110872/AS)
• 2,4,6-Trinitrotoluene     (PB/95/264297/AS) *

• Uranium     (Update) (PB/99/163362)

• Vanadium     (PB/93/110880/AS)
• Vinyl acetate     (PB/93/110898/AS)
• Vinyl chloride     (Update) (PB/98/101132/AS)

• White Phosphorus     (PB/98/101090/AS) *

• Xylenes     (Update) (PB/95/264404)

          None Available 

-Z-

• Zinc     (Update) (PB/95/100236/AS)

       Ammonia (Update)
       Chlorine dioxide
       Copper (Update)
       Polybrominated biphenyls/polybrominated diphenyl ethers        (Update)
       Synthetic Vitreous Fibers

The public comment period has ended and the profiles will be revised based on relevant public comments.

       Bromoform (Update)
       Carbon tetrachloride (Update)
       Hexachlorocyclohexanes (Update)
       Naphthalene (Update)
       Nickel (Update)
       Tin (Update)
       Tungsten
       Zinc (Update)

* The toxicological profile for perchlorates is on a modified schedule.

The public comment period has ended and the profiles will be revised based on relevant public comments.

Toxicological profiles under development as "draft for public comment" -- 

       Cyanide (Update)
       Dichlorobenzenes (Update)
       1,4-Dioxane
       Hydrogen sulfide (Update)
       1,1,1,-Trichloroethane (Update)
       Vinyl chloride (Update)

The CERCLA Set 18 profiles will be made available for public comment on or about October 17, 2004.

DOE Set 2

       Americium
       Cesium
       Cobalt (Update)
       Iodine
       Strontium

The public comment period has ended and the profiles will be revised on relevant public comments.

Editor's note: CERCLA is the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (Superfund).

List updated on June 7, 2004