| (dollars in thousands) |
| Core Scientific Areas |
| We will be able to accelerate our understanding of the causes of cancer through
large-scale studies in Genes and the Environment. | $73,150 |
| We will further explain the biological mechanisms that influence the development and progression
of cancer through studies on the Signatures of the Cancer Cell and Its Microenvironment. | $35,300 |
| As we more fully understand the causes, development, and progression of cancer, we will be
able to accelerate the validation of Molecular Targets of Prevention, Diagnosis, and Treatment. | $47,650 |
| And we will continue to expand the discovery and development of Imaging tools, accelerate the development of image-guided interventions, and stimulate research on in vivo Molecular Sensing. | $44,750 |
| Areas of Public Health Emphasis |
| We will continue to investigate the pervasiveness and causes of Tobacco Use and Tobacco-Related Cancers and apply this knowledge to prevention and treatment. | $75,000 |
| Studies in Optimizing Energy Balance will help us better understand the interactions among
weight, physical activity, diet, and cancer and apply this knowledge to cancer prevention
and control. | $57,800 |
| We will strengthen the scientific basis for public and private decision making to Improve the
Quality of Cancer Care on behalf of millions of people who do not receive adequate cancer care. | $36,300 |
| We will work to Reduce Cancer-Related Health Disparities for the untold numbers of
people who suffer because of social or economic status, cultural or language barriers, or
geographic location. | $71,300 |
| We will work to better understand Cancer Survivorship and develop interventions that will
optimize health and quality of life after cancer. | $30,250 |
|
| Investigator-Initiated Research builds on the synergism at institutions across the country to
ask the critical questions, explore research options, and develop and test innovative technologies. | $123,501 |
| Centers, Networks, and Consortia allow investigators to work in teams, collaborate for progress,
and ensure that results advance from discovery to intervention development and delivery. | $96,800 |
| NCI's National Clinical Trials Program provides the infrastructure to move new cancer
interventions from the laboratory to studies in people and then to the healthcare setting. | $334,900 |
|
| We will harness Bioinformatics tools to integrate data, capture and share research outcomes,
and provide tools for patients to interact more directly with cancer researchers. | $40,800 |
| As we better understand, apply, and disseminate effective Communication approaches, we will
be able to maximize access to and appropriate use of cancer information by all who need it. | $43,500 |
| Total Increase Request for Fiscal Year 2005 Priority Areas | $1,111,001 |
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| |
2003 Operating Budget |
2004 President's Budget |
2005 Budget Request |
| |
|
| (dollars in thousands) |
Increases |
Total |
|---|
|
| Research Project Grants (RFPs)
| | | | |
| Ongoing | $1,588,852 | $1,614,169 | $122,985 | $1,737,154 |
| New and Renewal | 491,556 | 523,295 | 471,429 | 994,724 |
|
| Subtotal RPGs | 2,080,408 | 2,137,464 | 594,414 | 2,731,878 |
|
| Small Business Innovation Research (SBIR) | 90,554 | 101,210 | 32,566 | 133,776 |
|
| Total RPGs | 2,170,962 | 2,238,674 | 626,980 | 2,865,654 |
| |
| Intramural Research | 648,227 | 704,551 | 59,000 | 763,551 |
| Cancer Centers | 267,430 | 302,281 | 120,225 | 422,506 |
| Specialized Programs of Research Excellence (SPOREs) | 163,403 | 170,700 | 65,383 | 236,083 |
| Clinical Trials Infrastructure | | | | |
| Cooperative Clinical Research | 156,582 | 180,330 | 149,851 | 330,181 |
| Community Clinical Oncology Program (CCOPs) | 95,905 | 95,458 | 76,200 | 171,658 |
|
| Subtotal Clinical Trials Infrastructure | 252,487 | 275,788 | 226,051 | 501,839 |
| |
| Training and Education Grants | | | | |
| National Research Service Awards | 66,570 | 75,048 | 3,477 | 78,525 |
| Research Career Program | 69,063 | 66,827 | 4,205 | 71,032 |
| Cancer Education Program | 30,849 | 32,206 | 4,563 | 36,769 |
| Minority Biomedical Research Support | 8,385 | 11,372 | 375 | 11,747 |
| Subtotal Training and Education Grants | 174,867 | 185,453 | 12,620 | 198,073 |
| |
| Cancer Control Operations | 172,021 | 174,355 | 21,204 | 195,559 |
| Research Support Contracts | 515,190 | 485,790 | 243,131 | 728,921 |
| Research Management and Support | 166,483 | 170,208 | 37,817 | 208,025 |
| Other Grants | 61,278 | 62,719 | 28,070 | 90,789 |
| Total Budget Request | $4,592,348 | $4,770,519 | $1,440,481 | $6,211,000 |
| |
| Cancer Control included above | 555,863 | 554,290 | 285,087 | 839,377 |
|
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| (dollars in thousands) |
Core |
Broad Research Priorities |
Platforms for Discovery, Development, and Delivery |
Enablers for Discovery, Development, and Delivery |
Total |
|
| Research Project Grants (RPGs) |
|
| |
Ongoing |
|
$122,985 |
|
|
|
$122,985 |
| |
New and Renewal |
|
62,378 |
$260,500 |
$131,551 |
$17,000 |
471,429 |
| |
|
| |
Subtotal RPGs |
185,363 |
260,500 |
131,551 |
17,000 |
594,414 |
| |
Small Business Innovation Research (SBIR) |
|
22,566 |
8,000 |
-- |
2,000 |
32,566 |
| |
|
| |
Total RPGs |
207,929 |
268,500 |
131,551 |
19,000 |
626,980 |
| Intramural Research |
33,250 |
15,500 |
9,500 |
750 |
59,000 |
| Cancer Centers |
9,975 |
13,250 |
96,000 |
1,000 |
120,225 |
| Specialized Programs of Research Excellence (SPOREs) |
5,633 |
40,750 |
18,000 |
1,000 |
65,383 |
| Clinical Trials Infrastructure |
|
| |
Cooperative Clinical Research |
5,951 |
9,000 |
134,900 |
-- |
149,851 |
| |
Community Clinical Oncology Program (CCOPs) |
3,150 |
1,500 |
71,550 |
-- |
76,200 |
|
| |
Subtotal Clinical Trials Infrastructure |
9,101 |
10,500 |
206,450 |
-- |
226,051 |
| Training and Education Grants |
|
| |
National Research Service Awards |
|
2,477 |
1,000 |
-- |
-- |
3,477 |
| |
Research Career Program |
|
2,205 |
2,000 |
-- |
-- |
4,205 |
| |
Cancer Education Program |
|
1,063 |
3,500 |
-- |
-- |
4,563 |
| |
Minority Biomedical Research Support |
|
375 |
-- |
-- |
-- |
375 |
|
| |
Subtotal Training and Education Grants |
6,120 |
6,500 |
-- |
-- |
12,620 |
| Cancer Control Operations |
13,754 |
2,450 |
5,000 |
-- |
21,204 |
| Research Support Contracts |
16,031 |
99,800 |
69,550 |
57,750 |
243,131 |
| Research Management and Support |
5,617 |
9,250 |
18,150 |
4,800 |
37,817 |
| Other Grants |
22,070 |
5,000 |
1,000 |
-- |
28,070 |
| |
Total Increase Request |
$329,480 |
$471,500 |
$555,201 |
$84,300 |
$1,440,481 |
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Research Project Grants
Funding for extramural research, primarily through investigator-initiated Research Project Grants (RPGs), comprises the largest part of the NCI core budget. Increases through the NCI Challenge and Extraordinary Opportunity initiatives contribute to the expansion of research supported through RPGs. NCI funds about 4,800 RPGs each year to nearly 600 institutions across the United States at an average cost of approximately $400,000 per grant. If fully supported, our budget request for Fiscal Year 2005 would add $594 million to the funds available to support investigator-initiated research.
Intramural Research
NCI intramural research focuses on projects conducted by some 400 researchers located on the NIH campus. These researchers build upon the proximity between their research laboratories and the NIH Clinical Center and the synergism among NIH Institutes to support the rapid translation of basic laboratory research to the clinic and to maintain a special focus on long-term epidemiologic and genetics studies.
Cancer Centers and Special Programs of Research Excellence (SPOREs)
Sixty NCI-supported Cancer Centers serve as hubs for cutting-edge research, high quality cancer care, and outreach and education for healthcare providers and patients. Centers of Excellence like the SPOREs use flexible funding to pursue questions related to specific forms of cancer and to move disease-specific research quickly from the laboratory to the patient. Funding increases will allow NCI to broaden the number and range of activities at Cancer Centers and SPOREs.
Clinical Trials Infrastructure
NCI supports clinical trials at the NIH clinical center and close to 3,000 other sites across the United States each year. Over 1,500 trials are conducted annually, involving more than 12,000 investigators assisting thousands of patients. These trials make possible the testing of targeted agents that hold promise for more effective, less invasive, cancer prevention and treatment and technologies that can be used for better detection and diagnosis. About three-quarters of this funding is for treatment trials and the other quarter supports prevention and screening trials.
Training and Education Grants
NCI funds approximately 200 institutions and 2,200 individuals each year through extramural cancer research training programs to prepare the next generation of scientists and clinicians to use new technologies and work effectively in interdisciplinary, collaborative research environments. Increased funding will be used to enhance these programs and to support the participation and growth of scientists within underserved populations.
Cancer Control
NCI's cancer control operational funds along with numerous grants and contracts included throughout the budget are used to support research, communication, and other activities focused on ways to reduce cancer risk, incidence, morbidity, and mortality and improve the quality of life for all cancer patients. Increases will be used to support research on tobacco and tobacco-related cancers, cancer-related health disparities, quality of cancer care, cancer survivorship, cancer communications, and a host of other information dissemination activities.
Research Support Contracts
Research support contracts are used to support program efforts across the Institute. Areas that utilize contracts are diverse and include such areas as drug development, cancer control research, information dissemination, and support to epidemiological research.
Research Management and Support
Research management and support budgets are used for the critical technical and administrative services required for NCI to carry out its work. They include central administrative functions, overall program direction, grant and contract review and administration, personnel, program coordination, and financial management.
Other Grants
Other grants support partnerships and shared resources and scientific evaluation, workshops, and conferences.
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