Director's Message

Executive Summary

• Introduction
• Disease-Specific Research
• Broad Research Priorities
• Platforms for Discovery, Development, and Delivery
• Enablers of Discovery, Development, and Delivery
• NCI's Budget Request for Fiscal Year 2005

Highlights of Progress

• Introduction
• Discovery
• Development
• Delivery

Our Action Plan for Fiscal Year 2005

• Introduction
• Discovery, Development, and Delivery as a Seamless Process
• Broad Research Priorities
• Toward Our Challenge Goal: Budget Increase Request for Fiscal Year 2005

NCI Budget Request for Fiscal Year 2005

• Requested Increases for Fiscal Year 2005
• Distribution of 2005 Budget Request
• Distribution of 2005 Increases
• Funding Area Descriptions

Disease Specific Research

• Introduction
• NCI's Planning and Evaluation Process for Disease-Specific Research
• Impacts of PRGs on Disease-Specific Research Agendas
• Collaborations for Assessing PRG Recommendations
• The Sarcoma Progress Review Group
• Modified Chemotherapy Regimen Improves Survival for Ewing's Sarcoma Patients

Broad Research Priorities

Core Scientific Areas

Genes and the Environment

• Goal
• Introduction
• Progress in Pursuit of Our Goal
• Objectives and Fiscal Year 2005 Milestones and Required Funding Increases

Signatures of the Cancer Cell and Its Microenvironment

• Goal
• Introduction
• Progress in Pursuit of Our Goal
• Objectives and Fiscal Year 2005 Milestones and Required Funding Increases
• Research on Cancer and Viruses - Attacking the Cancer Burden

Molecular Targets of Prevention, Diagnosis and Treatment

• Goal
• Introduction
• Progress in Pursuit of Our Goal
• Objectives and Fiscal Year 2005 Milestones and Required Funding Increases
• The Targeted Therapy Approach
• Turning Genes on to Fight Cancer: The Role of Histone Deacetylase Inhibitors in Cytotoxic T-Cell Lymphoma Therapy

Cancer Imaging and Molecular Sensing

• Goal
• Introduction
• Progress in Pursuit of Our Goal
• Objectives and Fiscal Year 2005 Milestones and Required Funding Increases
• ICMIC Scientists Develop a Biosensor to Permit Imaging of Molecular Interactions
• Imaging Researchers Develop Promising Cervical Cancer Screening Technique

Areas of Public Health Emphasis

Research on Tobacco and Tobacco-Related Cancers

• Goal
• Introduction
• Progress in Pursuit of Our Goal
• Objectives and Fiscal Year 2005 Milestones and Required Funding Increases
• NCI Develops New Framework for Interdisciplinary Studies
• People's Story: Tobacco-Related Cancers in Women - Smoking Raises the Risk of Many Cancers

Optimizing Energy Balance to Reduce the Cancer Burden

• Goal
• Introduction
• Progress in Pursuit of Our Goal
• Objectives and 2005 Milestones and Required Funding Increases
• People's Story: Energy In, Energy Out - A Critical Balance

Improving the Quality of Cancer Care

• Goal
• Introduction
• Progress in Pursuit of our Goal
• Objectives and Fiscal Year 2005 Milestones and Required Funding Increases
• People's Story: Symptom Management Research - Improving Quality of Life for Patients and Their Caregivers

Reducing Cancer-Related Health Disparities

• Goal
• Introduction
• Progress In Pursuit of Our Goal
• Objectives and Fiscal Year 2005 Milestones and Required Funding Increases
• Trans-HHS Initiative Applies Progress Review Approach to Health Disparities

NCI and NIA Launch New Efforts on Cancer and Aging

• Introduction
• Areas of Emphasis
• Percent of Cancer Deaths in the United States Among People 65 Years and Older

Cancer Survivorship: Optimizing Health and Quality of Life after Cancer

• Goal
• Introduction
• Progress in Pursuit of our Goal
• Objectives and Fiscal Year 2005 Milestones and Required Funding Increases
• Childhood Cancer Survivor Study Informs Intervention Development

Platforms for Discovery, Development and Delivery

Enhancing Investigator-Initiated Research

• Goal
• Introduction
• Progress in Pursuit of Our Goal
• Objectives and Fiscal Year 2005 Milestones and Required Funding Increases
• Investigator-Initiated Research in Bone Marrow Transplantation Spans the Discovery-Development-Delivery Continuum

Transforming the Capacity of Centers, Networks and Consortia

• Goal
• Introduction
• Progress In Pursuit of Our Goal
• Objectives and Fiscal Year 2005 Milestones and Required Funding Increases
• Cancer Centers Speed the Delivery of Research Benefits to Cancer Patients and to Populations at Risk for Cancer
• National Cancer Advisory Board Working Group Confirms Central Role of Cancer Centers and SPOREs in Delivery of Cancer Interventions

National Clinical Trials Program in Treatment and Prevention

• Goal
• Introduction
• Progress In Pursuit of Our Goal
• Objectives and Fiscal Year 2005 Milestones and Required Funding Increases
• NCI and FDA Partner to Streamline Cancer Drug Development
• Targeting Signaling Pathways with Drug Combinations

NCI Intramural Research Program Provides a Platform for Innovation, Translation and Application

Enablers of Discovery, Development, and Delivery

Bioinformatics

• Goal
• Introduction
• Progress In Pursuit of Our Goal
• Objectives and Fiscal Year 2005 Milestones and Required Funding Increases
• NCI's Center for Bioinformatics Serves as an Integrator for Cancer Research
• caBIG Will Expedite Access to Bioinformatics Resources

Cancer Communications

• Goal
• Introduction
• Progress In Pursuit Of Our Goal
• Objectives and Fiscal Year 2005 Milestones and Required Funding Increases
• New Online Tool Puts U.S.- and U.K.-Sponsored Cancer Research Information at Your Fingertips

Spotlights

Quality Patient Care Includes Radiation Oncology

Cancer Advocates Help Put a Human Face on Cancer Research

NCI Addresses Obstacles to New Treatments for Pediatric Cancer

NCI Partners to Advance Cancer Research

Story of Discovery

Harnessing Apoptosis to Destroy Cancer Cells

People's Stories

Tobacco-Related Cancers in Women - Smoking Raises the Risk of Many Cancers

Energy In, Energy Out - A Critical Balance

Symptom Management Research - Improving Quality of Life for Patients and Their Caregivers

Acknowledgements

Glossary

Links to Other Information

Frequently Asked Questions