CRADA Opportunities and Other Available NIH Technologies

• Animal Models for Hypertension and Related Complications

• Development of the Wip1 Protein (PPMD1) as a Target for Experimental Cancer Therapies

• Genomic Switch

• Development and commercialization of a new high speed method for DNA sequencing called Two Dye Sequencing (TDS).

• In Vivo Brain Elasticity Measurement by Magnetic Resonance Elastography with Vibrator Coil

• Identification and Development of Chemical Compounds That Interact With the Polo-box of Polo Kinases, as Potential Therapeutic Targets for the Inhibition of Cellular Proliferation.

• Development and Commercialization of an ATP-driven, Molecular Based Rotation Engine

• Development and Commercialization of a New Molecular Based Computing Device

• Development and Commercialization of A Kit for Detection and Quantification of Antigen Specific T Cells

• NCI Initiative to Develop a Diagnostic Microarray for Lymphoid Malignancies

• NCI Initiative to Identify Compounds Which Will Affect Tissue Response to Radiotherapy

• Steroids and Other Compounds that Interact with Tubulin

• Development of T-cell Epitope Models for Prevention, Early Detection, Diagnosis, and Treatment of Cancer and Infectious Diseases

• Development of Data Analysis Tools for Prevention, Early Detection, Diagnostic Classification, and Treatment of Cancer

• Development and Commercialization of Octanol to Treat Essential Tremors

• Scientific and Commercial Drug Development To Exploit Antiangiogenic Activity Targeting Adrenomedullin Gene Products

• Development of Scytovirin, a Unique anti-HIV Protein, for Microbicidal and/or Therapeutic Use(s)

• Development of Griffithsin, a Novel anti-HIV Protein with Potential Microbicidal, Therapeutic and/or Purification Utilities

• Chemical Optimization and Preclinical Development of Molecular-Targeted Anticancer, Antiviral and Antimicrobial Drug Leads

• Opportunity for a Cooperative Research and Development Agreement (CRADA) for the Development of New Drugs Altering T Cell Proliferation

• New Gene Expressed in Prostate Cancer (NGEP): Potential Target for Prostate Cancer Diagnostic and/or Therapeutic

• Novel Acylthiol Compositions: Potential Agents for the Treatment of HIV/AIDs That Selectively Target the HIV Nucleocapsid Protein (NCp7)

• Development and Commercialization of Analytical, Diagnostic and Therapeutic Methodologies in the Management of Older Adult in Patients Chronic Diseases States

• Opportunity for Cooperative Research and Development Agreement (CRADA) for Pre-clinical and Clinical Development of Zebularine

• Small Molecule Inhibitors of YopH, a Pathogenic Component of the Potential Bioterrorism Agent, Yersinia pestis

• Monitoring Spatial Distribution of Therapeutic Substances in the Brain

• Diagnostic Marker for Stroke Reperfusion

• Human Genetic Association Studies to Examine Risk Factors for Chronic Sciatica After Subacute Lumbar Disc Herniation

• A Method to Detect Ovarian Aging in Young Women

• Identification, Characterization and Development of Inhibitors of the p53 Tumor Suppressor Protein

• Chemical Optimization and Preclinical Development of HIV-1 Nucleocapsid-p7 Protein-Nucleic Acid Antagonists

• Development of the Chondropsins, Novel Antitumor Agents and Selective Vacuolar-H(+)-ATPase Inhibitors from a Marine Sponge

• Development of anti-CD 30 immunotoxins for the treatment of cancer

• Collaboration for the further Development of Peptides that inhibit HIV Replication

• Diagnostic and Clinical Management of Amenorrhea

• A Gene Critical to Human Fertility

• Chimeric VLPs for the Induction of Autoantibodies