Project
Title: ENGINEERING PLANT
ONE-CARBON (1-C) METABOLISM
Investigator |
Institution |
Award Amount |
Award Time Period |
Andrew D. Hanson |
University of Florida |
|
FY1999-FY2001 |
Co Prinicipal
Investigators/Related Projects:
Hans J. Bohnert (University of Arizona )
Douglas A. Gage (Michigan State
University )
David Rhodes (Purdue University )
Yair Shachar-Hill (New Mexico State
University)
Sponsored by: National Science Foundation
Project Number: 9813999
Brief
Description of Project:
Primary and secondary metabolism intersect in the one-carbon
(1-C) area with primary metabolism supplying most of the 1-C
units and competing with secondary metabolism for their use.
This competition is potentially severe because plant secondary
metabolism imposes hugh demands for 1-C units, especially methyl
groups for the synthesis of lignin, alkaloids and osmoprotectant
compounds such as glycine betaine and D-onoitol. As many current
metabolic engineering projects aim to change levels of these
products, and hence methyl group demand, it is essential that
one understands how 1-C metabolism is regulated so that one can
successfully engineer the 1-C supply to match demand. To do this
requires skills in molecular biology, metabolic and analytical
chemistry, in vivo NMR, and computer modeling. These skills will
come from five Principal Investigators (PIs) with complementary
and overlapping expertise. All PIs are used to doing
interdisciplinary teamwork.
Supporting Publications:
Project
Starting Date: 01/99 (MM/YY)
Project
Ending Date (Planned):
12/2001 (MM/YY)
Research Area: |
Analytical Methods/Sensors/Meas., Pathway
Modeling |
Potential Field of Use: |
Basic Research |
Federal
Contact Name:
DOE Contact:
Valerie Reed
E-Mail:
valerie.sarisky-reed@hq.doe.gov
Phone: (202)586-5618
NIST Contact: Vince Vilker
E-Mail: vilker@micf.nist.gov
Phone: (301)975-5066
NSF Contact: Fred G. Heineken
E-Mail:
fheineke@nsf.gov
Phone: (703)306-1319
Last
Revision: 02/22/00
|