Project
Title: Genomically Based
Models for Antimicrobial Development
Investigator |
Institution |
Award Amount |
Award Time Period |
Bernhard Palsson |
University of California-San Diego |
|
FY1998-FY2002 |
Co Prinicipal
Investigators/Related Projects:
Bernhard Palsson (U.C San Diego)[NSF-BES]
Bernhard Palsson (U.C San Diego)[NSF-KDI]
Sponsored by: National Institutes of Health
Project Number: 5R01GM57089-02
Brief
Description of Project:
The proposal
details a novel means of meeting the challenge of antibiotic
resistance of pathogenic organisms. It is based on the
assumption that genomic information for the pathogen of interest
is complete enough to permit useful probabilities of finding
weak points to exploit. The goal of the proposal is to determine
the sensitivity of the organism to deletion of individual genes
or relatively small groups of genes. In this way it is hoped to
find deletions which are lethal to the organism but at the same
time harmless for the human host. At a more detailed level the
proposal lays out mathematical procedures for finding lethal
deletions and for putting the results in convenient form for the
investigator. Only computer simulations will be made, and it is
not expected to find any promising new antibiotics. Rather the
proposal is to investigate the feasibility and potential utility
of the procedures outlined.
Project Starting Date: 08/98
Project Ending Date (Planned): 07/02
Research Area: |
Bioinformatics/Genetics |
Potential Field of Use: |
Basic Research; Medical |
Federal Contact Name:
NIH Contact:
Warren Jones Email: jonesw@nigms.nih.gov
Phone:(301)594-5938
Last Revision: 02/22/2000
|