| Investigators |
Institution |
Award Amount |
Award Time Period |
Eleftherios T. Papoutsakis
Neil E. Welker |
Northwestern University |
|
FY2000-FY2002 |
Co Prinicipal
Investigators/Related Projects:
Eleftherios T. Papoutsakis[EPA]
Sponsored by: National Science Foundation
Project Number:
NIH: BES-9911231
Brief Description of Project:
| The objective of this project is to understand the molecular basis of solvent
tolerance in Clostridium acetobutylicum, with the purpose of using this information to
obtain strains that produce higher concentrations of solvents. The research is organized
around two hypotheses: (1) that the ability to produce high concentrations of solvent
(butanol), and also butanol tolerance, is enhanced by increased protein stability in
strains that overexpress heat-shock proteins; and (2) that butanol tolerance is enhanced
by expression of native solvent/drug resistance genes, e. g. proteins of the multidrug
efflux family. |
Project Starting Date: 07/2000
Project Ending Date (Planned): 06/0002
Federal Contact Name:
NSF Contact: Fred G. Heineken E-Mail: Fheineke@nsf.gov Phone:(703)306-1319
Last Revision: January 12, 2001
|
