RAPID ACCESS TO PREVENTIVE INTERVENTION DEVELOPMENT (RAPID) PROGRAM

Projects and Investigators

FY 2001 Projects

American Health Foundation

Objective:
Preclinical development of sulforaphane, a major constituent in broccoli.

Program Description:
Investigators will conduct preclinical development of sulforaphane, a major constituent in broccoli. The consumption of cruciferous vegetables is associated with a reduced risk of cancer at various organ sites. Isothiocyanates are abundantly present in these vegetables and are thought to be major contributors to their chemopreventive activities. Sulforaphane is a major isothiocyanate in broccoli and has shown chemopreventive activity in various animal models. RAPID support will include:

synthesis of bulk and 14C-labeled material for preclinical studies, mutagenicity and short term preclinical toxicity testing, preclinical absorption, distribution, metabolism, elimination and pharmacokinetic studies, in vivo screening and efficacy studies, and formulation.

Contact Information:

Fung-Lung Chung, Ph.D.
Presently
Professor
Department of Oncology
Lombardi Comprehensive Cancer Center
Georgetown University Medical Center
3800 Reservoir Rd. NW LL(S) level
Rm 128, Box 571465
Washington, DC 20057-1465
Tel: 202-687-3021
Email: flc6@georgetown.edu

	RAPID ACCESS TO PREVENTIVE INTERVENTION DEVELOPMENT (RAPID) PROGRAM Projects and Investigators FY 2001 Projects American Health Foundation Objective: Preclinical development of sulforaphane, a major constituent in broccoli. Program Description: Investigators will conduct preclinical development of sulforaphane, a major constituent in broccoli. The consumption of cruciferous vegetables is associated with a reduced risk of cancer at various organ sites. Isothiocyanates are abundantly present in these vegetables and are thought to be major contributors to their chemopreventive activities. Sulforaphane is a major isothiocyanate in broccoli and has shown chemopreventive activity in various animal models. RAPID support will include: synthesis of bulk and 14C-labeled material for preclinical studies, mutagenicity and short term preclinical toxicity testing, preclinical absorption, distribution, metabolism, elimination and pharmacokinetic studies, in vivo screening and efficacy studies, and formulation. Contact Information: Fung-Lung Chung, Ph.D. Presently Professor Department of Oncology Lombardi Comprehensive Cancer Center Georgetown University Medical Center 3800 Reservoir Rd. NW LL(S) level Rm 128, Box 571465 Washington, DC 20057-1465 Tel: 202-687-3021 Email: flc6@georgetown.edu



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