RAPID ACCESS TO PREVENTIVE INTERVENTION DEVELOPMENT (RAPID) PROGRAM

Projects and Investigators

FY 2003 Projects

Dr. Denis E. Corpet

Objective:
Chemoprevention of Colorectal Tumors by Dietary Polyethylene Glycol (PEG).

Program Description:
Investigators will conduct preclinical development of Dietary Polyethylene Glycol (PEG). Water-soluble, high molecular weight polymeric polyethylene glycols are used as food additives and gentle laxatives. They are not absorbed from the gastro-intestinal tract and nor are they metabolized by gut microflora. They possess low toxicity and have recently showed chemopreventive activity in carcinogen-induced colon cancer in rats. Supporting scientific documentation will be presented for consideration of a phase 1/2 clinical study with modulation of aberrant crypt foci as the primary endpoint.

Contact Information:

Dr. Denis E. Corpet
Tel: 33-561-1939-82
Fax: 33-561-491-263
e-mail: d.corpet@envt.fr

	RAPID ACCESS TO PREVENTIVE INTERVENTION DEVELOPMENT (RAPID) PROGRAM Projects and Investigators FY 2003 Projects Dr. Denis E. Corpet Objective: Chemoprevention of Colorectal Tumors by Dietary Polyethylene Glycol (PEG). Program Description: Investigators will conduct preclinical development of Dietary Polyethylene Glycol (PEG). Water-soluble, high molecular weight polymeric polyethylene glycols are used as food additives and gentle laxatives. They are not absorbed from the gastro-intestinal tract and nor are they metabolized by gut microflora. They possess low toxicity and have recently showed chemopreventive activity in carcinogen-induced colon cancer in rats. Supporting scientific documentation will be presented for consideration of a phase 1/2 clinical study with modulation of aberrant crypt foci as the primary endpoint. Contact Information: Dr. Denis E. Corpet Tel: 33-561-1939-82 Fax: 33-561-491-263 e-mail: d.corpet@envt.fr



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