RAPID ACCESS TO PREVENTIVE INTERVENTION DEVELOPMENT (RAPID) PROGRAM

Projects and Investigators

FY 2001 Projects

Dartmouth Medical School

Objective:
Bulk synthesis of the new triterpenoids, 2-Carboxy-DDO methyl ester and its homolog, 2-Carboxy-DDO ethyl ester.

Program Description:
Investigators will conduct preclinical development of the new triterpenoids, 2-Carboxy-DDO methyl ester and its homolog, 2-Carboxy-DDO ethyl ester. These 2 new triterpenoids were synthesized to obviate some of the in vivo limitations of their predecessors, namely poor pharmacokinetic profile. Preliminary data suggest that these compounds have numerous activities in cell culture (including inhibition of inducible nitric oxide synthetase and cyclooxygenase-2 and binding to PPAR-g receptor) and in vivo that are relevant to prevention of human cancer. RAPID support will include:

bulk synthesis of these compounds.

Contact Information:

Michael B. Sporn
Dartmouth Medical School
Dartmouth, NH
Tel: 603-650-6557
Fax: 603-650-1129
e-mail: Micahel.B.Sporn@Dartmouth.edu

View investigator's other projects

	RAPID ACCESS TO PREVENTIVE INTERVENTION DEVELOPMENT (RAPID) PROGRAM Projects and Investigators FY 2001 Projects Dartmouth Medical School Objective: Bulk synthesis of the new triterpenoids, 2-Carboxy-DDO methyl ester and its homolog, 2-Carboxy-DDO ethyl ester. Program Description: Investigators will conduct preclinical development of the new triterpenoids, 2-Carboxy-DDO methyl ester and its homolog, 2-Carboxy-DDO ethyl ester. These 2 new triterpenoids were synthesized to obviate some of the in vivo limitations of their predecessors, namely poor pharmacokinetic profile. Preliminary data suggest that these compounds have numerous activities in cell culture (including inhibition of inducible nitric oxide synthetase and cyclooxygenase-2 and binding to PPAR-g receptor) and in vivo that are relevant to prevention of human cancer. RAPID support will include: bulk synthesis of these compounds. Contact Information: Michael B. Sporn Dartmouth Medical School Dartmouth, NH Tel: 603-650-6557 Fax: 603-650-1129 e-mail: Micahel.B.Sporn@Dartmouth.edu View investigator's other projects



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