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CHEMOPREVENTIVE AGENT DEVELOPMENT RESEARCH GROUP

Funding Opportunities

Announcement of Request for Proposals (RFP): N01-CN-25002-02 - Preclinical Toxicology of New Cancer Preventive Agents using Work Assignments

The Division of Cancer Prevention (DCP), National Cancer Institute (NCI) is seeking proposals from qualified organizations who have the ability to to evaluate the preclinical toxicology and pharmacology of potential cancer preventive agents. The studies will include, for example, evaluations of mutagenicity, acute and subchronic and chronic toxicity, carcinogenicity, teratogenicity and reproductive effects, pharmacokinetics, metabolism and supporting analytical methods validation, pharmacological effects on gene and protein expression, and specialized studies such as immunological, neurological, and other assessments as necessary. The studies will be used to qualify agents for clinical studies and in many cases to support Investigational New Drug (IND) applications to the Food and Drug Administration (FDA) for phase 1 - 3 clinical studies and New Drug Applications (NDA) to the FDA. The agents to be studied shall include agents developed by the pharmaceutical and other industries and provided to the NCI for collaborative development as well as commercially available agents, agents developed by the NCI, and agents nominated by academic investigators through the RAPID program (http://www3.cancer.gov/prevention/rapid/). Application due date is April 30, 2003. See the following website for additional details: http://rcb.cancer.gov/rcb-internet/appl/rfp/25002/toc.pdf.

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Research Group in the Division of Cancer Prevention

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