BIOMETRY RESEARCH GROUP
Mathematica Packages
Periodic Screening Evaluation
(Written by Stuart G. Baker)
New Approach (Simplified Approximation): See Baker SG. Evaluating periodic cancer screening without a randomized control group: a simplified design and analysis. In: Duffy SW, Hill C, Esteve J (eds). Methods of Evaluation of Cancer Screening. To
appear.
Original Approach: Periodic Screening Evaluation is a method for estimating the reduction in mortality from starting periodic cancer screening at various ages based on either data from a special nonrandomized or randomized design. The methodology is described in Baker SG. Evaluating the age to begin periodic breast cancer screening using data from a few regularly scheduled screens. Biometrics 1998;54:1569-1578. It simplifies and extends Baker SG, Chu KC. Evaluating screening for the early detection and treatment of cancer without using a randomized control group. Journal of the American Statistical Association 1990;85:321-327.
It runs in Mathematica 2.2 or 3.0 and requires the files listed below.
To reproduce calculations in the manuscript, load pse.m and use the function PSEHIP[dataHIP, a, z].
- Data are available in psedata.m
- dataOBS is for nonrandomized study
- dataRAN is for a randomized study.
- These should be modified with new data.
- To run PSE for ages, say 40 to 50, with mortality endpoint use
- PSEOBS[dataOBS,a,z,{40,50},"MORT"] for a nonrandomized study
PSERAN[dataRAN,a,z,{40,50},"MORT"] for a randomized study.