Health Professionals Follow-up Study
This study is no longer recruiting patients.
Purpose
To test the hypothesis that increased risk of coronary heart disease, stroke, peripheral vascular disease, and cancer is related
to diets high in saturated fat, animal protein, and hydrogenated vegetable oil, and low in polyunsaturated fat, fiber, vitamins
A, C, and E, calcium, selenium, and chromium.
| Condition
|
Cardiovascular Diseases
Cerebrovascular Accident
Coronary Disease
Peripheral Vascular Diseases
Heart Diseases
Myocardial Infarction
|
MedlinePlus related topics: Circulatory Disorders; Coronary Disease; Heart Attack; Heart Diseases; Heart Diseases--Prevention; Stroke
Study Type: Observational
Study Design: Natural History
Further Study Details:
Study start: December 1985;
Study completion: May 2007
BACKGROUND: The diet-heart hypothesis, that high dietary saturated fat and cholesterol intake increase the risk and high polyunsaturated
fat reduces the risk of coronary heart disease in man is supported by ecologic studies, by experiments in rodents and non-human
primates, by voluminous literature relating dietary factors to serum lipids, by several secondary prevention trials, and by
the Lipid Research Clinics Trial demonstrating a reduction in coronary heart disease among participants assigned to cholestyramine.
Despite the substantial scientific interest and the obvious public health implications of the diet and heart disease issue,
relatively few observational cohort or case-control investigations had been published prior to 1985. Although these observational
studies were not entirely consistent, taken collectively, they tended to provide important general support for the diet-heart
hypothesis. However, due to study design, limited numbers of endpoints, or methods of analysis, many central questions remained
unanswered. The most important issue was the quantitative relationship between specific dietary factors and risk of coronary
heart disease.
DESIGN NARRATIVE: In this prospective cohort study, participants completed a mailed general medical and health questionnaire
at baseline and an intensively validated semiquantitative food frequency questionnaire (SFFQ). At one year, tissue specimens
were collected and catalogued for future nested case-control analyses of coronary heart disease risk in relation to levels
of calcium, selenium, and chromium. Follow-up questionnaires to update exposure information and ascertain non-fatal endpoints
were mailed at two-year intervals. All reported cases of non-fatal myocardial infarction, stroke, and cancer were documented
with hospital records and/or pathology reports. Fatal events were ascertained with the National Death Index and documented.
To standardize SFFQ nutrient scores against measurements of absolute intake, two one-week diet records were obtained from
a random sample of 150 Boston-area participants.
The study was renewed in 1991, 1997, and in 2003 to continue the follow-up of 51,529 male health professionals. The cohort
is followed by questionnaires mailed at two-year intervals to update exposure information and ascertain nonfatal events.
Complete dietary assessments are included every four years.
Eligibility
Genders Eligible for Study:
Male
No eligibility criteria
Location
Information
Study chairs or principal investigators
Eric Rimm, Harvard School of Public Health
More Information
Publications
MacIntosh DL, Williams PL, Hunter DJ, Sampson LA, Morris SC, Willett WC, Rimm EB. Evaluation of a food frequency questionnaire-food
composition approach for estimating dietary intake of inorganic arsenic and methylmercury. Cancer Epidemiol Biomarkers Prev.
1997 Dec;6(12):1043-50.
Giovannucci E, Rimm EB, Wolk A, Ascherio A, Stampfer MJ, Colditz GA, Willett WC. Calcium and fructose intake in relation
to risk of prostate cancer. Cancer Res. 1998 Feb 1;58(3):442-7.
Welch G, Kawachi I, Barry MJ, Giovannucci E, Colditz GA, Willett WC. Distinction between symptoms of voiding and filling
in benign prostatic hyperplasia: findings from the Health Professionals Follow-up Study. Urology. 1998 Mar;51(3):422-7.
Madore F, Stampfer MJ, Rimm EB, Curhan GC. Nephrolithiasis and risk of hypertension. Am J Hypertens. 1998 Jan;11(1 Pt 1):46-53.
Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Willett WC. Diabetes mellitus and risk of prostate cancer (United States).
Cancer Causes Control. 1998 Jan;9(1):3-9.
Coakley EH, Rimm EB, Colditz G, Kawachi I, Willett W. Predictors of weight change in men: results from the Health Professionals
Follow-up Study. Int J Obes Relat Metab Disord. 1998 Feb;22(2):89-96.
Aldoori WH, Giovannucci EL, Rockett HR, Sampson L, Rimm EB, Willett WC. A prospective study of dietary fiber types and symptomatic
diverticular disease in men. J Nutr. 1998 Apr;128(4):714-9.
Aldoori WH, Giovannucci EL, Rimm EB, Wing AL, Willett WC. Use of acetaminophen and nonsteroidal anti-inflammatory drugs:
a prospective study and the risk of symptomatic diverticular disease in men. Arch Fam Med. 1998 May-Jun;7(3):255-60.
Rosner B, Willett WC. Interval estimates for correlation coefficients corrected for within-person variation: implications
for study design and hypothesis testing. Am J Epidemiol. 1988 Feb;127(2):377-86.
Rimm EB, Stampfer MJ, Colditz GA, Giovannucci E, Willett WC. Effectiveness of various mailing strategies among nonrespondents
in a prospective cohort study. Am J Epidemiol. 1990 Jun;131(6):1068-71.
Hunter DJ, Rimm EB, Sacks FM, Stampfer MJ, Colditz GA, Litin LB, Willett WC. Comparison of measures of fatty acid intake
by subcutaneous fat aspirate, food frequency questionnaire, and diet records in a free-living population of US men. Am J Epidemiol.
1992 Feb 15;135(4):418-27.
Rimm EB, Giovannucci EL, Willett WC, Colditz GA, Ascherio A, Rosner B, Stampfer MJ. Prospective study of alcohol consumption
and risk of coronary disease in men. Lancet. 1991 Aug 24;338(8765):464-8.
Ascherio A, Stampfer MJ, Colditz GA, Willett WC, McKinlay J. Nutrient intakes and blood pressure in normotensive males. Int
J Epidemiol. 1991 Dec;20(4):886-91.
Giovannucci E, Colditz G, Stampfer MJ, Rimm EB, Litin L, Sampson L, Willett WC. The assessment of alcohol consumption by
a simple self-administered questionnaire. Am J Epidemiol. 1991 Apr 15;133(8):810-7.
Colditz GA, Rimm EB, Giovannucci E, Stampfer MJ, Rosner B, Willett WC. A prospective study of parental history of myocardial
infarction and coronary artery disease in men. Am J Cardiol. 1991 May 1;67(11):933-8.
Ching PL, Willett WC, Rimm EB, Colditz GA, Gortmaker SL, Stampfer MJ. Activity level and risk of overweight in male health
professionals. Am J Public Health. 1996 Jan;86(1):25-30.
Curhan GC, Willett WC, Rimm EB, Spiegelman D, Stampfer MJ. Prospective study of beverage use and the risk of kidney stones.
Am J Epidemiol. 1996 Feb 1;143(3):240-7.
Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett WC. Intake of carotenoids and retinol in relation to
risk of prostate cancer. J Natl Cancer Inst. 1995 Dec 6;87(23):1767-76.
Giovannucci E, Rimm EB, Chute CG, Kawachi I, Colditz GA, Stampfer MJ, Willett WC. Obesity and benign prostatic hyperplasia.
Am J Epidemiol. 1994 Dec 1;140(11):989-1002.
Aldoori WH, Giovannucci EL, Rimm EB, Wing AL, Trichopoulos DV, Willett WC. A prospective study of alcohol, smoking, caffeine,
and the risk of symptomatic diverticular disease in men. Ann Epidemiol. 1995 May;5(3):221-8.
Rimm EB, Stampfer MJ, Giovannucci E, Ascherio A, Spiegelman D, Colditz GA, Willett WC. Body size and fat distribution as
predictors of coronary heart disease among middle-aged and older US men. Am J Epidemiol. 1995 Jun 15;141(12):1117-27.
Kearney J, Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Ascherio A, Bleday R, Willett WC. Diet, alcohol, and smoking
and the occurrence of hyperplastic polyps of the colon and rectum (United States). Cancer Causes Control. 1995 Jan;6(1):45-56.
Giovannucci E, Rimm EB, Ascherio A, Stampfer MJ, Colditz GA, Willett WC. Alcohol, low-methionine--low-folate diets, and risk
of colon cancer in men. J Natl Cancer Inst. 1995 Feb 15;87(4):265-73.
Giovannucci E, Willett WC. Dietary factors and risk of colon cancer. Ann Med. 1994 Dec;26(6):443-52. Review.
Rimm EB, Chan J, Stampfer MJ, Colditz GA, Willett WC. Prospective study of cigarette smoking, alcohol use, and the risk of
diabetes in men. BMJ. 1995 Mar 4;310(6979):555-9.
Ascherio A, Rimm EB, Stampfer MJ, Giovannucci EL, Willett WC. Dietary intake of marine n-3 fatty acids, fish intake, and
the risk of coronary disease among men. N Engl J Med. 1995 Apr 13;332(15):977-82.
Aldoori WH, Giovannucci EL, Rimm EB, Ascherio A, Stampfer MJ, Colditz GA, Wing AL, Trichopoulos DV, Willett WC. Prospective
study of physical activity and the risk of symptomatic diverticular disease in men. Gut. 1995 Feb;36(2):276-82.
Giovannucci E, Ascherio A, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. Physical activity, obesity, and risk for colon cancer
and adenoma in men. Ann Intern Med. 1995 Mar 1;122(5):327-34.
Chan JM, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. Obesity, fat distribution, and weight gain as risk factors for clinical
diabetes in men. Diabetes Care. 1994 Sep;17(9):961-9.
Connolly B, Kelehan P, O'Brien N, Gorman W, Murphy JF, King M, Donoghue V. The echogenic thalamus in hypoxic ischaemic encephalopathy.
Pediatr Radiol. 1994;24(4):268-71.
Aldoori WH, Giovannucci EL, Rimm EB, Wing AL, Trichopoulos DV, Willett WC. A prospective study of diet and the risk of symptomatic
diverticular disease in men. Am J Clin Nutr. 1994 Nov;60(5):757-64.
Hemenway D, Azrael DR, Rimm EB, Feskanich D, Willett WC. Risk factors for wrist fracture: effect of age, cigarettes, alcohol,
body height, relative weight, and handedness on the risk for distal forearm fractures in men. Am J Epidemiol. 1994 Aug 15;140(4):361-7.
Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Ascherio A, Willett WC. Aspirin use and the risk for colorectal cancer and
adenoma in male health professionals. Ann Intern Med. 1994 Aug 15;121(4):241-6.
Kawachi I, Colditz GA, Ascherio A, Rimm EB, Giovannucci E, Stampfer MJ, Willett WC. Prospective study of phobic anxiety and
risk of coronary heart disease in men. Circulation. 1994 May;89(5):1992-7.
Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Ascherio A, Willett WC. Intake of fat, meat, and fiber in relation to risk
of colon cancer in men. Cancer Res. 1994 May 1;54(9):2390-7.
Curhan GC, Rimm EB, Willett WC, Stampfer MJ. Regional variation in nephrolithiasis incidence and prevalence among United
States men. J Urol. 1994 Apr;151(4):838-41.
Ascherio A, Willett WC, Rimm EB, Giovannucci EL, Stampfer MJ. Dietary iron intake and risk of coronary disease among men.
Circulation. 1994 Mar;89(3):969-74.
Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Ascherio A, Kearney J, Willett WC. A prospective study of cigarette smoking
and risk of colorectal adenoma and colorectal cancer in U.S. men. J Natl Cancer Inst. 1994 Feb 2;86(3):183-91.
Feskanich D, Rimm EB, Giovannucci EL, Colditz GA, Stampfer MJ, Litin LB, Willett WC. Reproducibility and validity of food
intake measurements from a semiquantitative food frequency questionnaire. J Am Diet Assoc. 1993 Jul;93(7):790-6.
Rimm E, Colditz G. Smoking, alcohol, and plasma levels of carotenes and vitamin E. Ann N Y Acad Sci. 1993 May 28;686:323-33;
discussion 333-4. Review.
Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC. Vitamin E consumption and the risk of coronary heart
disease in men. N Engl J Med. 1993 May 20;328(20):1450-6.
Curhan GC, Willett WC, Rimm EB, Stampfer MJ. A prospective study of dietary calcium and other nutrients and the risk of symptomatic
kidney stones. N Engl J Med. 1993 Mar 25;328(12):833-8.
Giovannucci E, Ascherio A, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. A prospective cohort study of vasectomy and prostate
cancer in US men. JAMA. 1993 Feb 17;269(7):873-7.
Kearney J, Giovannucci E, Rimm EB, Ascherio A, Stampfer MJ, Colditz GA, Wing A, Kampman E, Willett WC. Calcium, vitamin D,
and dairy foods and the occurrence of colon cancer in men. Am J Epidemiol. 1996 May 1;143(9):907-17.
Stampfer MJ, Rimm EB. Folate and cardiovascular disease. Why we need a trial now. JAMA. 1996 Jun 26;275(24):1929-30. No abstract
available.
Chasan-Taber S, Rimm EB, Stampfer MJ, Spiegelman D, Colditz GA, Giovannucci E, Ascherio A, Willett WC. Reproducibility and
validity of a self-administered physical activity questionnaire for male health professionals. Epidemiology. 1996 Jan;7(1):81-6.
Willett WC. Diet, nutrition, and avoidable cancer. Environ Health Perspect. 1995 Nov;103 Suppl 8:165-70. Review.
Joshipura KJ, Willett WC, Douglass CW. The impact of edentulousness on food and nutrient intake. J Am Dent Assoc. 1996 Apr;127(4):459-67.
Curhan GC, Willett WC, Rimm EB, Stampfer MJ. A prospective study of the intake of vitamins C and B6, and the risk of kidney
stones in men. J Urol. 1996 Jun;155(6):1847-51.
Rimm EB, Ascherio A, Giovannucci E, Spiegelman D, Stampfer MJ, Willett WC. Vegetable, fruit, and cereal fiber intake and
risk of coronary heart disease among men. JAMA. 1996 Feb 14;275(6):447-51.
Ascherio A, Rimm EB, Giovannucci EL, Spiegelman D, Stampfer M, Willett WC. Dietary fat and risk of coronary heart disease
in men: cohort follow up study in the United States. BMJ. 1996 Jul 13;313(7049):84-90.
Joshipura KJ, Rimm EB, Douglass CW, Trichopoulos D, Ascherio A, Willett WC. Poor oral health and coronary heart disease.
J Dent Res. 1996 Sep;75(9):1631-6.
Walker SP, Rimm EB, Ascherio A, Kawachi I, Stampfer MJ, Willett WC. Body size and fat distribution as predictors of stroke
among US men. Am J Epidemiol. 1996 Dec 15;144(12):1143-50.
Aldoori WH, Giovannucci EL, Stampfer MJ, Rimm EB, Wing AL, Willett WC. Prospective study of diet and the risk of duodenal
ulcer in men. Am J Epidemiol. 1997 Jan 1;145(1):42-50.
Curhan GC, Willett WC, Rimm EB, Spiegelman D, Ascherio AL, Stampfer MJ. Birth weight and adult hypertension, diabetes mellitus,
and obesity in US men. Circulation. 1996 Dec 15;94(12):3246-50.
Joshipura KJ, Douglass CW, Garcia RI, Valachovic R, Willett WC. Validity of a self-reported periodontal disease measure.
J Public Health Dent. 1996 Summer;56(4):205-12.
Kawachi I, Barry MJ, Giovannucci E, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. The impact of different therapies on symptoms
of benign prostatic hyperplasia: a prospective study. Clin Ther. 1996 Nov-Dec;18(6):1118-27.
Salmeron J, Ascherio A, Rimm EB, Colditz GA, Spiegelman D, Jenkins DJ, Stampfer MJ, Wing AL, Willett WC. Dietary fiber, glycemic
load, and risk of NIDDM in men. Diabetes Care. 1997 Apr;20(4):545-50.
Kawachi I, Colditz GA, Ascherio A, Rimm EB, Giovannucci E, Stampfer MJ, Willett WC. A prospective study of social networks
in relation to total mortality and cardiovascular disease in men in the USA. J Epidemiol Community Health. 1996 Jun;50(3):245-51.
Aldoori WH, Giovannucci EL, Stampfer MJ, Rimm EB, Wing AL, Willett WC. A prospective study of alcohol, smoking, caffeine,
and the risk of duodenal ulcer in men. Epidemiology. 1997 Jul;8(4):420-4.
Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Willett WC. Height, body weight, and risk of prostate cancer. Cancer Epidemiol
Biomarkers Prev. 1997 Aug;6(8):557-63.
Platz EA, Giovannucci E, Rimm EB, Rockett HR, Stampfer MJ, Colditz GA, Willett WC. Dietary fiber and distal colorectal adenoma
in men. Cancer Epidemiol Biomarkers Prev. 1997 Sep;6(9):661-70.
Owusu W, Willett WC, Feskanich D, Ascherio A, Spiegelman D, Colditz GA. Calcium intake and the incidence of forearm and hip
fractures among men. J Nutr. 1997 Sep;127(9):1782-7.
Curhan GC, Willett WC, Rimm EB, Stampfer MJ. Family history and risk of kidney stones. J Am Soc Nephrol. 1997 Oct;8(10):1568-73.
Hu FB, Stampfer MJ, Rimm EB, Manson JE, Ascherio A, Colditz GA, Rosner BA, Spiegelman D, Speizer FE, Sacks FM, Hennekens CH,
Willett WC. A prospective study of egg consumption and risk of cardiovascular disease in men and women. JAMA. 1999 Apr 21;281(15):1387-94.
Miller M, Hemenway D, Rimm E. Cigarettes and suicide: a prospective study of 50,000 men. Am J Public Health. 2000 May;90(5):768-73.
Platz EA, Kawachi I, Rimm EB, Willett WC, Giovannucci E. Race, ethnicity and benign prostatic hyperplasia in the health professionals
follow-up study. J Urol. 2000 Feb;163(2):490-5.
van Dam RM, Huang Z, Giovannucci E, Rimm EB, Hunter DJ, Colditz GA, Stampfer MJ, Willett WC. Diet and basal cell carcinoma
of the skin in a prospective cohort of men. Am J Clin Nutr. 2000 Jan;71(1):135-41.
Platz EA, Pollak MN, Rimm EB, Majeed N, Tao Y, Willett WC, Giovannucci E. Racial variation in insulin-like growth factor-1
and binding protein-3 concentrations in middle-aged men. Cancer Epidemiol Biomarkers Prev. 1999 Dec;8(12):1107-10.
Brown L, Rimm EB, Seddon JM, Giovannucci EL, Chasan-Taber L, Spiegelman D, Willett WC, Hankinson SE. A prospective study
of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr. 1999 Oct;70(4):517-24.
Meigs JB, Barry MJ, Giovannucci E, Rimm EB, Stampfer MJ, Kawachi I. Incidence rates and risk factors for acute urinary retention:
the health professionals followup study. J Urol. 1999 Aug;162(2):376-82.
Ascherio A, Rimm EB, Hernan MA, Giovannucci E, Kawachi I, Stampfer MJ, Willett WC. Relation of consumption of vitamin E,
vitamin C, and carotenoids to risk for stroke among men in the United States. Ann Intern Med. 1999 Jun 15;130(12):963-70.
Leitzmann MF, Giovannucci EL, Stampfer MJ, Spiegelman D, Colditz GA, Willett WC, Rimm EB. Prospective study of alcohol consumption
patterns in relation to symptomatic gallstone disease in men. Alcohol Clin Exp Res. 1999 May;23(5):835-41.
Leitzmann MF, Willett WC, Rimm EB, Stampfer MJ, Spiegelman D, Colditz GA, Giovannucci E. A prospective study of coffee consumption
and the risk of symptomatic gallstone disease in men. JAMA. 1999 Jun 9;281(22):2106-12.
Ascherio A, Rimm EB, Hernan MA, Giovannucci EL, Kawachi I, Stampfer MJ, Willett WC. Intake of potassium, magnesium, calcium,
and fiber and risk of stroke among US men. Circulation. 1998 Sep 22;98(12):1198-204.
Curhan GC, Willett WC, Rimm EB, Speizer FE, Stampfer MJ. Body size and risk of kidney stones. J Am Soc Nephrol. 1998 Sep;9(9):1645-52.
Verhoef P, Rimm EB, Hunter DJ, Chen J, Willett WC, Kelsey K, Stampfer MJ. A common mutation in the methylenetetrahydrofolate
reductase gene and risk of coronary heart disease: results among U.S. men. J Am Coll Cardiol. 1998 Aug;32(2):353-9.
Madore F, Stampfer MJ, Rimm EB, Curhan GC. Nephrolithiasis and risk of hypertension. Am J Hypertens. 1998 Jan;11(1 Pt 1):46-53.
Chu NF, Spiegelman D, Rifai N, Hotamisligil GS, Rimm EB. Glycemic status and soluble tumor necrosis factor receptor levels
in relation to plasma leptin concentrations among normal weight and overweight US men. Int J Obes Relat Metab Disord. 2000
Sep;24(9):1085-92.
Hu FB, Rimm EB, Stampfer MJ, Ascherio A, Spiegelman D, Willett WC. Prospective study of major dietary patterns and risk of
coronary heart disease in men. Am J Clin Nutr. 2000 Oct;72(4):912-21.
Ascherio A, Rimm EB, Giovannucci E, Willett WC, Stampfer MJ. Blood donations and risk of coronary heart disease in men. Circulation.
2001 Jan 2;103(1):52-7.
Fung TT, Hu FB, Yu J, Chu NF, Spiegelman D, Tofler GH, Willett WC, Rimm EB. Leisure-time physical activity, television watching,
and plasma biomarkers of obesity and cardiovascular disease risk. Am J Epidemiol. 2000 Dec 15;152(12):1171-8.
Fung TT, Rimm EB, Spiegelman D, Rifai N, Tofler GH, Willett WC, Hu FB. Association between dietary patterns and plasma biomarkers
of obesity and cardiovascular disease risk. Am J Clin Nutr. 2001 Jan;73(1):61-7.
McCullough ML, Feskanich D, Rimm EB, Giovannucci EL, Ascherio A, Variyam JN, Spiegelman D, Stampfer MJ, Willett WC. Adherence
to the Dietary Guidelines for Americans and risk of major chronic disease in men. Am J Clin Nutr. 2000 Nov;72(5):1223-31.
Joshipura KJ, Ascherio A, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, Hennekens CH, Spiegelman D, Willett WC. Fruit and
vegetable intake in relation to risk of ischemic stroke. JAMA. 1999 Oct 6;282(13):1233-9.
Willett W, Stampfer M, Chu NF, Spiegelman D, Holmes M, Rimm E. Assessment of questionnaire validity for measuring total fat
intake using plasma lipid levels as criteria. Am J Epidemiol. 2001 Dec 15;154(12):1107-12.
Conigrave KM, Hu BF, Camargo CA Jr, Stampfer MJ, Willett WC, Rimm EB. A prospective study of drinking patterns in relation
to risk of type 2 diabetes among men. Diabetes. 2001 Oct;50(10):2390-5.
Chu NF, Spiegelman D, Hotamisligil GS, Rifai N, Stampfer M, Rimm EB. Plasma insulin, leptin, and soluble TNF receptors levels
in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men. Atherosclerosis.
2001 Aug;157(2):495-503.
Field AE, Coakley EH, Must A, Spadano JL, Laird N, Dietz WH, Rimm E, Colditz GA. Impact of overweight on the risk of developing
common chronic diseases during a 10-year period. Arch Intern Med. 2001 Jul 9;161(13):1581-6.
Hu FB, Willett WC. Diet and coronary heart disease: findings from the Nurses' Health Study and Health Professionals' Follow-up
Study. J Nutr Health Aging. 2001;5(3):132-8. Review.
Hu FB, Leitzmann MF, Stampfer MJ, Colditz GA, Willett WC, Rimm EB. Physical activity and television watching in relation
to risk for type 2 diabetes mellitus in men. Arch Intern Med. 2001 Jun 25;161(12):1542-8.
Joshipura KJ, Hu FB, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, Colditz G, Ascherio A, Rosner B, Spiegelman D, Willett WC.
The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med. 2001 Jun 19;134(12):1106-14.
Chu NF, Spiegelman D, Yu J, Rifai N, Hotamisligil GS, Rimm EB. Plasma leptin concentrations and four-year weight gain among
US men. Int J Obes Relat Metab Disord. 2001 Mar;25(3):346-53.
Chu NF, Stampfer MJ, Spiegelman D, Rifai N, Hotamisligil GS, Rimm EB. Dietary and lifestyle factors in relation to plasma
leptin concentrations among normal weight and overweight men. Int J Obes Relat Metab Disord. 2001 Jan;25(1):106-14.
van Dam RM, Willett WC, Rimm EB, Stampfer MJ, Hu FB. Dietary fat and meat intake in relation to risk of type 2 diabetes in
men. Diabetes Care. 2002 Mar;25(3):417-24.
van Dam RM, Rimm EB, Willett WC, Stampfer MJ, Hu FB. Dietary patterns and risk for type 2 diabetes mellitus in U.S. men.
Ann Intern Med. 2002 Feb 5;136(3):201-9.
Fung TT, Hu FB, Pereira MA, Liu S, Stampfer MJ, Colditz GA, Willett WC. Whole-grain intake and the risk of type 2 diabetes:
a prospective study in men. Am J Clin Nutr. 2002 Sep;76(3):535-40.
Eng PM, Rimm EB, Fitzmaurice G, Kawachi I. Social ties and change in social ties in relation to subsequent total and cause-specific
mortality and coronary heart disease incidence in men. Am J Epidemiol. 2002 Apr 15;155(8):700-9.
Grobbee DE, Rimm EB, Giovannucci E, Colditz G, Stampfer M, Willett W. Coffee, caffeine, and cardiovascular disease in men.
N Engl J Med. 1990 Oct 11;323(15):1026-32.
Bacon CG, Hu FB, Giovannucci E, Glasser DB, Mittleman MA, Rimm EB. Association of type and duration of diabetes with erectile
dysfunction in a large cohort of men. Diabetes Care. 2002 Aug;25(8):1458-63.
Cho E, Rimm EB, Stampfer MJ, Willett WC, Hu FB. The impact of diabetes mellitus and prior myocardial infarction on mortality
from all causes and from coronary heart disease in men. J Am Coll Cardiol. 2002 Sep 4;40(5):954-60.
Tanasescu M, Leitzmann MF, Rimm EB, Willett WC, Stampfer MJ, Hu FB. Exercise type and intensity in relation to coronary heart
disease in men. JAMA. 2002 Oct 23;288(16):1994-2000.
He K, Rimm EB, Merchant A, Rosner BA, Stampfer MJ, Willett WC, Ascherio A. Fish consumption and risk of stroke in men. JAMA.
2002 Dec 25;288(24):3130-6.
Goldberg IJ: To drink or not to drink? N Engl J Med, 348(2):163-164, 2003. Editorial. No abstract available.
Yoshizawa K, Rimm EB, Morris JS, Spate VL, Hsieh CC, Spiegelman D, Stampfer MJ, Willett WC. Mercury and the risk of coronary
heart disease in men. N Engl J Med. 2002 Nov 28;347(22):1755-60.
Mukamal KJ, Conigrave KM, Mittleman MA, Camargo CA Jr, Stampfer MJ, Willett WC, Rimm EB. Roles of drinking pattern and type
of alcohol consumed in coronary heart disease in men. N Engl J Med. 2003 Jan 9;348(2):109-18.
Hung HC, Willett W, Merchant A, Rosner BA, Ascherio A, Joshipura KJ. Oral health and peripheral arterial disease. Circulation.
2003 Mar 4;107(8):1152-7.
Al-Delaimy WK, Rimm E, Willett WC, Stampfer MJ, Hu FB. A prospective study of calcium intake from diet and supplements and
risk of ischemic heart disease among men. Am J Clin Nutr. 2003 Apr;77(4):814-8.
Tanasescu M, Leitzmann MF, Rimm EB, Hu FB. Physical activity in relation to cardiovascular disease and total mortality among
men with type 2 diabetes. Circulation. 2003 May 20;107(19):2435-9. Epub 2003 Apr 28.
Tanasescu M, Leitzmann MF, Rimm EB, Hu FB. Physical activity in relation to cardiovascular disease and total mortality among
men with type 2 diabetes. Circulation. 2003 May 20;107(19):2435-9. Epub 2003 Apr 28.
Pischon T, Hotamisligil GS, Rimm EB. Adiponectin: stability in plasma over 36 hours and within-person variation over 1 year.
Clin Chem. 2003 Apr;49(4):650-2. No abstract available.
Joshi A, Douglass CW, Kim HD, Joshipura KJ, Park MC, Rimm EB, Carino MJ, Garcia RI, Morris JS, Willett WC. The relationship
between amalgam restorations and mercury levels in male dentists and nondental health professionals. J Public Health Dent.
2003 Winter;63(1):52-60.
Augustsson K, Michaud DS, Rimm EB, Leitzmann MF, Stampfer MJ, Willett WC, Giovannucci E. A prospective study of intake of
fish and marine fatty acids and prostate cancer. Cancer Epidemiol Biomarkers Prev. 2003 Jan;12(1):64-7.
Joshipura KJ, Hung HC, Rimm EB, Willett WC, Ascherio A. Periodontal disease, tooth loss, and incidence of ischemic stroke.
Stroke. 2003 Jan;34(1):47-52.
Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Willett WC, Rimm EB. Habitual dietary intake of n-3 and n-6 fatty acids
in relation to inflammatory markers among US men and women. Circulation. 2003 Jul 15;108(2):155-60. Epub 2003 Jun 23.
Meyer KA, Conigrave KM, Chu NF, Rifai N, Spiegelman D, Stampfer MJ, Rimm EB. Alcohol consumption patterns and HbA1c, C-peptide
and insulin concentrations in men. J Am Coll Nutr. 2003 Jun;22(3):185-94.
Yoshizawa K, Ascherio A, Morris JS, Stampfer MJ, Giovannucci E, Baskett CK, Willett WC, Rimm EB. Prospective study of selenium
levels in toenails and risk of coronary heart disease in men. Am J Epidemiol. 2003 Nov 1;158(9):852-60.
Koh-Banerjee P, Chu NF, Spiegelman D, Rosner B, Colditz G, Willett W, Rimm E. Prospective study of the association of changes
in dietary intake, physical activity, alcohol consumption, and smoking with 9-y gain in waist circumference among 16 587 US
men. Am J Clin Nutr. 2003 Oct;78(4):719-27.
He K, Merchant A, Rimm EB, Rosner BA, Stampfer MJ, Willett WC, Ascherio A. Dietary fat intake and risk of stroke in male
US healthcare professionals: 14 year prospective cohort study. BMJ. 2003 Oct 4;327(7418):777-82.
Hung HC, Willett W, Ascherio A, Rosner BA, Rimm E, Joshipura KJ. Tooth loss and dietary intake. J Am Dent Assoc. 2003 Sep;134(9):1185-92.
Hung HC, Merchant A, Willett W, Ascherio A, Rosner BA, Rimm E, Joshipura KJ. The association between fruit and vegetable
consumption and peripheral arterial disease. Epidemiology. 2003 Nov;14(6):659-65.
Newby PK, Hu FB, Rimm EB, Smith-Warner SA, Feskanich D, Sampson L, Willett WC. Reproducibility and validity of the Diet
Quality Index Revised as assessed by use of a food-frequency questionnaire. Am J Clin Nutr. 2003 Nov;78(5):941-9.
Merchant AT, Pitiphat W, Ahmed B, Kawachi I, Joshipura K. A prospective study of social support, anger expression and risk
of periodontitis in men. J Am Dent Assoc. 2003 Dec;134(12):1591-6.
Salazar-Martinez E, Willett WC, Ascherio A, Manson JE, Leitzmann MF, Stampfer MJ, Hu FB. Coffee consumption and risk for
type 2 diabetes mellitus. Ann Intern Med. 2004 Jan 6;140(1):1-8. Summary for patients in: Ann Intern Med. 2004 Jan 6;140(1):I17.
Lopez-Ridaura R, Willett WC, Rimm EB, Liu S, Stampfer MJ, Manson JE, Hu FB. Magnesium intake and risk of type 2 diabetes
in men and women. Diabetes Care. 2004 Jan;27(1):134-40.
He K, Merchant A, Rimm EB, Rosner BA, Stampfer MJ, Willett WC, Ascherio A. Folate, vitamin B6, and B12 intakes in relation
to risk of stroke among men. Stroke. 2004 Jan;35(1):169-74. Epub 2003 Dec 11.
Merchant AT, Hu FB, Spiegelman D, Willett WC, Rimm EB, Ascherio A. Dietary fiber reduces peripheral arterial disease risk
in men. J Nutr. 2003 Nov;133(11):3658-63.
Schulze MB, Rimm EB, Shai I, Rifai N, Hu FB. Relationship between adiponectin and glycemic control, blood lipids, and inflammatory
markers in men with type 2 diabetes. Diabetes Care. 2004 Jul;27(7):1680-7.
Cho E, Seddon JM, Rosner B, Willett WC, Hankinson SE. Prospective study of intake of fruits, vegetables, vitamins, and carotenoids
and risk of age-related maculopathy. Arch Ophthalmol. 2004 Jun;122(6):883-92.
Koh-Banerjee P, Wang Y, Hu FB, Spiegelman D, Willett WC, Rimm EB. Changes in body weight and body fat distribution as risk
factors for clinical diabetes in US men. Am J Epidemiol. 2004 Jun 15;159(12):1150-9.
Kang JH, Pasquale LR, Willett WC, Rosner BA, Egan KM, Faberowski N, Hankinson SE. Dietary fat consumption and primary open-angle
glaucoma. Am J Clin Nutr. 2004 May;79(5):755-64.
Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G. Alcohol intake and risk of incident gout in men: a prospective study.
Lancet. 2004 Apr 17;363(9417):1277-81.
Platz EA, Leitzmann MF, Hollis BW, Willett WC, Giovannucci E. Plasma 1,25-dihydroxy- and 25-hydroxyvitamin D and subsequent
risk of prostate cancer. Cancer Causes Control. 2004 Apr;15(3):255-65.
Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm EB. Plasma adiponectin levels and risk of myocardial infarction
in men. JAMA. 2004 Apr 14;291(14):1730-7.
Schulze MB, Rimm EB, Li T, Rifai N, Stampfer MJ, Hu FB. C-reactive protein and incident cardiovascular events among men
with diabetes. Diabetes Care. 2004 Apr;27(4):889-94.
Bohler J, Woitas R, Keller E, Reetze-Bonorden P, Schollmeyer PJ. Effect of nifedipine and captopril on glomerular hyperfiltration
in normotensive man. Am J Kidney Dis. 1992 Aug;20(2):132-9.
Al-Delaimy WK, Rimm EB, Willett WC, Stampfer MJ, Hu FB. Magnesium intake and risk of coronary heart disease among men. J
Am Coll Nutr. 2004 Feb;23(1):63-70.
Study ID Numbers:
1060
Record last reviewed:
July 2004
Record first received:
May 25, 2000
ClinicalTrials.gov Identifier:
NCT00005182Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2004-10-29
