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A substance that is being studied in the treatment of cancer. |
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An anticancer drug that belongs to the family of drugs called enzyme inhibitors. It may inhibit the transformation of normal cells into cancer cells. |
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A form of carnitine, which is a substance made in the muscles and liver. It can be given as a supplement to prevent and treat carnitine deficiency in patients who are receiving chemotherapy for cancer or undergoing dialysis for kidney disease. Also called levocarnitine. |
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Research done in a laboratory. These studies may use test tubes or animals to find out if a drug, procedure, or treatment is likely to be useful. Laboratory studies take place before any testing is done in humans. |
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A medical procedure that involves testing a sample of blood, urine, or other substance from the body. Tests can help determine a diagnosis, plan treatment, check to see if treatment is working, or monitor the disease over time. |
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A gland that secretes tears. The lacrimal glands are found in the upper, outer part of each eye socket. |
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LDH. One of a group of enzymes found in the blood and other body tissues, and involved in energy production in cells. An increased amount in the blood may be a sign of tissue damage and some types of cancer or other diseases. Also called lactic acid dehydrogenase. |
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One of a group of enzymes found in the blood and other body tissues, and involved in energy production in cells. An increased amount in the blood may be a sign of tissue damage and some types of cancer or other diseases. Also called lactate dehydrogenase. |
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A type of sugar found in milk and milk products. |
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The inability to digest or absorb lactose, a type of sugar found in milk and other dairy products. |
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A white blood cell that is stimulated in a laboratory to kill tumor cells. Also called a lymphokine-activated killer cell. |
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A type of connective tissue found under the thin layer of tissues covering a mucous membrane. |
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A drug used to treat infection caused by viruses. |
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A drug that is used to help control some types of seizures. It is being studied in the prevention of peripheral neuropathy caused by some chemotherapy drugs. It belongs to the family of drugs called anticonvulsants. |
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(LAP-a-ruh-skope)
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A thin, lighted tube used to look at tissues and organs inside the abdomen.
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(LAP-a-ruh-SKOP-ik pros-ta-TEK-toe-mee)
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Surgery to remove all or part of the prostate with the aid of a laparoscope (a thin, lighted tube). |
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(LAP-uh-ruh-SCOP-ik)
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Surgery done with the aid of a laparoscope (a thin, lighted tube) to remove all or part of the colon through several small incisions made in the wall of the abdomen. A laparoscope attached to a video camera is inserted through one opening to guide the surgery. Surgical instruments are inserted through the other openings to perform the surgery. When only part of the colon is removed, it is called a partial colectomy. |
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(lap-a-RAHS-ko-pee)
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The insertion of a thin, lighted tube (called a laparoscope) through the abdominal wall to inspect the inside of the abdomen and remove tissue samples. |
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(lap-a-RAH-toe-mee)
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A surgical incision made in the wall of the abdomen. |
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Arctium lappa. A plant whose seeds and root have been used in some cultures to treat certain medical problems. It may have antioxidant effects. Also called burdock and happy major. |
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(kar-sin-O-ma)
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Lung cancer in which the cells are large and look abnormal when viewed under a microscope. |
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A type of white blood cell that contains granules with enzymes that can kill tumor cells or microbial cells. Also called a natural killer cell. |
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The long, tube-like organ that is connected to the small intestine at one
end and the anus at the other. The large intestine has four parts: cecum,
colon, rectum, and anal canal. Partly digested food moves through the cecum
into the colon, where water and some nutrients and electrolytes are removed.
The remaining material, solid waste called stool, moves through the colon, is
stored in the rectum, and leaves the body through the anal canal and anus. |
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(lair-IN-jee-al)
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Having to do with the larynx. |
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(lair-in-JEK-toe-mee)
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A person whose larynx (voice box) has been removed. |
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(LAIR-in-JEK-tuh-mee)
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An operation to remove all or part of the larynx (voice box). |
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Inflammation of the larynx. |
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(la-RING-guh-skope)
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A thin, lighted tube used to examine the larynx (voice box). |
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(LAIR-in-GOSS-kuh-pee)
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Examination of the larynx (voice box) with a mirror (indirect laryngoscopy) or with a laryngoscope (direct laryngoscopy). |
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(LAIR-inks)
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The area of the throat containing the vocal cords and used for breathing, swallowing, and talking. Also called the voice box. |
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(LAY-zer)
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A device that concentrates light into an intense, narrow beam used to cut or destroy tissue. It is used in microsurgery, photodynamic therapy, and for a variety of diagnostic purposes. |
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A surgical procedure that uses the cutting power of a laser beam to make bloodless cuts in tissue or to remove a surface lesion such as a tumor. |
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The use of an intensely powerful beam of light to kill cancer cells. |
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Describes a condition that is present but not active or causing symptoms. |
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A substance that promotes bowel movements. |
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Lobular carcinoma in situ. Abnormal cells found in the lobules of the breast. This condition seldom becomes invasive cancer; however, having lobular carcinoma in situ increases one's risk of developing breast cancer in either breast. |
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Lactate dehydrogenase. One of a group of enzymes found in the blood and other body tissues, and involved in energy production in cells. An increased amount in the blood may be a sign of tissue damage and some types of cancer or other diseases. Also called lactic acid dehydrogenase. |
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A complex molecule that has both protein and sugars. Lectins are able to bind to the outside of a cell and cause biochemical changes in it. Lectins are made by both animals and plants. |
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An anticancer drug that works by inhibiting a cancer cell growth factor. Also called SU101. |
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A benign smooth muscle tumor, usually in the uterus or gastrointestinal tract. Also called fibroid. |
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A malignant (cancerous) tumor of smooth muscle cells that
can arise almost anywhere in the body, but is most common in the uterus,
abdomen, or pelvis. |
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A beta-glucan (a type of polysaccharide) from the mushroom Lentinus edodes (shiitake mushroom). It has been studied in Japan as a treatment for cancer. |
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A drug that inhibits blood clotting. It is being studied in cancer treatment. |
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Having to do with the two innermost layers of tissues that cover the brain and spinal cord. |
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A tumor that involves the tissues that cover the brain and spinal cord. |
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Cancer that has spread from the original (primary) tumor to the tissues that cover the brain and spinal cord. |
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A substance that is being studied for its ability to stimulate the production of blood cells during chemotherapy. It belongs to the family of drugs called colony-stimulating factors. Also known as SC-70935. |
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A drug that prevents or reduces nausea and vomiting. |
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(LEE-zhun)
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An area of abnormal tissue. A lesion may be benign (noncancercous) or malignant (cancerous). |
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An anticancer drug that belongs to the family of drugs called nonsteroidal aromatase inhibitors. Letrozole is used to decrease estrogen production and suppress the growth of estrogen-dependent tumors. |
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A drug used to protect normal cells from high doses of the anticancer drug methotrexate. It is also used to increase the antitumor effects of fluorouracil and tegafur-uracil, an oral treatment alternative to intravenous fluorouracil. |
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Removal of the blood to collect specific blood cells; the remaining blood is returned to the body. |
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(loo-KEE-mee-a)
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Cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of blood cells to be produced and enter the bloodstream. |
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(LOO-ko-site)
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A white blood cell. Refers to a blood cell that does not contain hemoglobin. White blood cells include lymphocytes, neutrophils, eosinophils, macrophages, and mast cells. These cells are made by bone marrow and help the body fight infection and other diseases. |
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(LOO-ko-PEE-nya)
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A condition in which the number of leukocytes (white blood cells) in the blood is reduced. |
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(loo-ko-PLAY-kee-a)
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An abnormal patch of white tissue that forms on mucous membranes in the mouth and other areas of the body. It may become cancerous. Tobacco (smoking and chewing) and alcohol may increase the risk of leukoplakia in the mouth. |
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(LOO-pro-lide)
| |
A drug that belongs to the family of drugs called gonadotropin-releasing hormone analogs. It is used to block hormone production in the ovaries or testicles. |
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An agent that delivers the gene for interleukin-2 (IL-2) into cells to increase production of IL-2 by the cells. |
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An antiparasitic drug that is also being studied in cancer therapy with fluorouracil. |
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A form of carnitine, which is a substance made in the muscles and liver. It can be given as a supplement to prevent and treat carnitine deficiency in patients who are receiving chemotherapy for cancer or undergoing dialysis for kidney disease. Also called L-carnitine. |
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A substance used to treat bacterial infections. It belongs to the family of drugs called quinolone antibiotics. |
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An anticancer drug used to decrease the growth of some types of cancer cells. It belongs to the family of drugs called retinoids. Also called bexarotene. |
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Luteinizing hormone-releasing hormone. A hormone that stimulates the production of sex hormones in men and women. |
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(lair-MEETS)
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A sensation similar to an electrical shock radiating from the back of the head down the spine as the neck is bent forward. |
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A rare, inherited predisposition to multiple cancers, caused by an alteration in the p53 tumor suppressor gene. |
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An anticancer drug that promotes differentiation by increasing the levels of retinoic acid within the tumor. |
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(LYE-doe-kane)
| |
A substance that is used to relieve pain by blocking signals at the nerve endings in skin. It can also be given intravenously to stop heart arrhythmias. It belongs to the families of drugs called local anesthetics and antiarrhythmics. |
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(lye-GAY-shun)
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The process of tying off blood vessels so that blood cannot flow to a part of the body or to a tumor. |
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A microscope (device to magnify small objects) in which objects are lit directly by white light. |
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LED therapy. Treatment with drugs that become active and may kill cancer cells when exposed to light. LED therapy is type of photodynamic therapy which uses a special type of light to activate the drug. |
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A member of a group of substances found in plants that have shown estrogenic and anticancer effects. Lignans have been used in some cultures to treat certain medical problems. |
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(per-FYOO-zhun)
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A technique that may be used to deliver anticancer drugs directly to an arm or leg. The flow of blood to and from the limb is temporarily stopped with a tourniquet, and anticancer drugs are put directly into the blood of the limb. This allows the person to receive a high dose of drugs in the area where the cancer occurred. Also called isolated limb perfusion. |
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Cancer is found in one lung, the tissues between the lungs, and nearby lymph nodes only. |
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A machine that creates high-energy radiation to treat cancer, using electricity to form a stream of fast-moving subatomic particles. Also called mega-voltage (MeV) linear accelerator or a linear accelerator. |
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A machine that creates high-energy radiation to treat cancer, using electricity to form a stream of fast-moving subatomic particles. Also called mega-voltage (MeV) linear accelerator or a linac. |
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The seed of the flax plant. It is a rich source of omega-3 fatty acid, fiber, and a compound called lignin. It is being studied in the prevention of prostate cancer. Also called flaxseed. |
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A thyroid hormone. Also called triiodothyronine or T-3. |
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Able to dissolve, be dissolved in, or absorb lipids (fats). |
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A rare cancer of the fat cells. |
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A drug preparation that contains the active drug in very tiny fat particles. This fat-encapsulated drug is absorbed better, and its distribution to the tumor site is improved. |
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A drug that may protect healthy cells from chemotherapy and radiation without inhibiting the effects of these therapies on tumor cells. |
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A large organ located in the upper abdomen. The liver cleanses the blood and aids in digestion by secreting bile. |
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A disease in which malignant (cancer) cells are found in the tissues of the liver. |
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Cancer that has spread from the original (primary) tumor to the liver. |
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An image of the liver created on a computer screen or on film. A radioactive substance is injected into a blood vessel and travels through the bloodstream. It collects in the liver, especially in abnormal areas, and can be detected by the scanner. |
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A toxic substance linked to an antibody that attaches to tumor cells and kills them. |
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A toxic substance linked to an antibody that attaches to tumor cells and kills them. |
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A toxic substance linked to an antibody that attaches to tumor cells and kills them. |
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A toxic substance linked to an antibody that attaches to tumor cells and kills them. |
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An anticancer drug that belongs to the family of drugs called platinum compounds. |
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A portion of an organ, such as the liver, lung, breast, thyroid, or brain. |
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(lo-BEK-toe-mee)
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A substance that is being studied for its ability to help other drugs reach the brain. It belongs to the family of drugs called bradykinin agonists. Also called RMP-7. |
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(LOB-yoo-lar KAR-si-NO-ma in SYE-too)
| |
LCIS. A condition in which abnormal cells are found in the lobules of the breast. LCIS seldom becomes invasive cancer; however, having lobular carcinoma in situ in one breast increases the risk of developing breast cancer in either breast. |
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(LOB-yule)
| |
A small lobe or a subdivision of a lobe. |
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(an-es-THEE-zha)
| |
Drugs that cause a temporary loss of feeling in one part of the body. The patient remains awake but has no feeling in the part of the body treated with the anesthetic. |
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An invasive malignant cancer confined entirely to the organ where the cancer began. |
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Treatment that affects cells in the tumor and the area close to it. |
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(LO-kal-ih-ZAY-shun)
| |
The process of determining or marking the location or site of a lesion or disease. May also refer to the process of keeping a lesion or disease in a specific location or site. |
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Restricted to the site of origin, without evidence of spread. |
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Cancer found only in the tissues that make up the wall of the gallbladder. Localized gallbladder cancer can be removed completely in an operation. |
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Cancer that has spread only to nearby tissues or lymph nodes. |
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A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called antifolates. |
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| |
An anticancer drug that belongs to the family of drugs called alkylating agents. |
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| |
An anticancer drug that belongs to the family of drugs called enzyme inhibitors. Also called SCH 66336. |
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| |
LEEP. A technique that uses electric current passed through a thin wire loop to remove abnormal tissue. Also called loop excision. |
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| |
A technique that uses electric current passed through a thin wire loop to remove abnormal tissue. Also called loop electrosurgical excision procedure (LEEP). |
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An anticancer drug that belongs to the family of drugs called antipyrazoles. |
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| |
When referring to cancerous and precancerous growths, a term used to describe cells that look nearly normal under a microscope. These cells are less likely to grow and spread quickly than cells in high-grade cancerous or precancerous growths. |
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A type of lymphoma that tends to grow and spread slowly, and has few symptoms. Also called indolent lymphoma. |
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X-rays of the colon and rectum (lower gastrointestinal tract) that are taken after a person is given a barium enema. |
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An anticancer drug that kills cancer cells by affecting DNA synthesis. |
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| |
An anticancer drug that reduces the risk of tumor cell growth and reproduction. |
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(LOO-brih-kant)
| |
An oily or slippery substance. |
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| |
A procedure in which a needle is put into the lower part of the spinal column to collect cerebrospinal fluid or to give anticancer drugs intrathecally. Also called a spinal tap.
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| |
The cavity or channel within a tube or tubular organ such as a blood vessel or the intestine. |
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(lump-EK-toe-mee)
| |
Surgery to remove the tumor and a small amount of normal tissue around it. |
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| |
One of a pair of organs in the chest that supplies the body with oxygen, and removes carbon dioxide from the body. |
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| |
Cancer that has spread from the original (primary) tumor to the lung. |
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| |
A chronic inflammatory connective tissue disease marked by skin rashes, joint pain and swelling, inflammation of the kidneys, inflammation of the fibrous tissue surrounding the heart (i.e., the pericardium), as well as other problems. Not all affected individuals display all of these problems. Also called systemic lupus erythematosus. |
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| |
An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors. |
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| |
LH-RH. A hormone that stimulates the production of sex hormones in men and women. |
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(LOO-tin-eye-zing. . .AG-o-nist)
| |
LH-RH agonist. A drug that inhibits the secretion of sex hormones. In men, LH-RH agonist causes testosterone levels to fall. In women, LH-RH agonist causes the levels of estrogen and other sex hormones to fall. |
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| |
A substance that is being studied in photodynamic therapy. It belongs to the family of drugs called metallotexaphyrins. |
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| |
A substance that is being studied as a treatment for
cancer. It belongs to the family of drugs called enzyme inhibitors. Also
called pemetrexed disodium. |
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| |
A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called leukotriene B4 receptor antagonists. |
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| |
A substance that is being studied as a treatment for cancer. It belongs to the family
of drugs called angiogenesis inhibitors.
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| |
A substance that is being studied for its ability to reverse resistance to chemotherapy. Also called zosuquidar trihydrochloride. |
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| |
A hormone substance used in the treatment of some types of cancer. |
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(LIE-kuh-peen)
| |
A red pigment found in tomatoes and some fruits. It is an antioxidant and may help prevent some types of cancer. |
|
(limf)
| |
The clear fluid that travels through the lymphatic system and carries cells that help fight infections and other diseases. Also called lymphatic fluid. |
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| |
A rounded mass of lymphatic tissue that is surrounded by a capsule of connective tissue. Lymph glands filter lymph (lymphatic fluid), and they store lymphocytes (white blood cells). They are located along lymphatic vessels. Also called a lymph node. |
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(limf node)
| |
A rounded mass of lymphatic tissue that is surrounded by a capsule of connective tissue. Lymph nodes filter lymph (lymphatic fluid), and they store lymphocytes (white blood cells). They are located along lymphatic vessels. Also called a lymph gland. |
|
(limf node dis-EK-shun)
| |
A surgical procedure in which lymph nodes are removed and examined to see whether they contain cancer. Also called lymphadenectomy. |
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| |
The flow of lymph from an area of tissue into a particular lymph node. |
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| |
The use of dyes and radioactive substances to identify lymph nodes that may contain tumor cells. Also called lymphatic mapping. |
|
(limf)
| |
A thin tube that carries lymph (lymphatic fluid) and white blood cells through the lymphatic system. Also called lymphatic vessel. |
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| |
A surgical procedure in which the lymph nodes are removed and examined to see whether they contain cancer. For a regional lymph node dissection, some of the lymph nodes in the tumor area are removed; for a radical lymph node dissection, most or all of the lymph nodes in the tumor area are removed. Also called lymph node dissection. |
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| |
Disease or swelling of the lymph nodes. |
|
(lim-FAN-jee-o-gram)
| |
An x-ray of the lymphatic system. A dye is injected into a lymphatic vessel and travels throughout the lymphatic system. The dye outlines the lymphatic vessels and organs on the x-ray. |
|
(lim-FAN-jee-AH-gra-fee)
| |
An x-ray study of the lymphatic system. A dye is injected into a lymphatic vessel and travels throughout the lymphatic system. The dye outlines the lymphatic vessels and organs on the x-ray. |
|
| |
A type of cancer that begins in the cells that line lymph vessels. |
|
(lim-FAT-ik)
| |
The clear fluid that travels through the lymphatic system and carries cells that help fight infections and other diseases. Also called lymph. |
|
| |
The use of dyes and radioactive substances to identify lymph nodes that may contain tumor cells. Also called lymph node mapping. |
|
(lim-FAT-ik SIS-tem)
| |
The tissues and organs that produce, store, and carry white blood cells that fight infections and other diseases. This system includes the bone marrow, spleen, thymus, lymph nodes, and lymphatic vessels (a network of thin tubes that carry lymph and white blood cells). Lymphatic vessels branch, like blood vessels, into all the tissues of the body. |
|
(lim-FAT-ik)
| |
A thin tube that carries lymph (lymphatic fluid) and white blood cells through the lymphatic system. Also called lymph vessel. |
|
(LIMF-eh-DEE-ma)
| |
A condition in which excess fluid collects in tissue and causes swelling. It may occur in the arm or leg after lymph vessels or lymph nodes in the underarm or groin are removed or treated with radiation. |
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| |
A lymphocyte that has gotten larger after being stimulated by
an antigen. Lymphoblasts look like immature lymphocytes, and were once
thought to be precursor cells.
|
|
(LIM-fo-site)
| |
A type of white blood cell. Lymphocytes have a number of roles in the immune system, including the production of antibodies and other substances that fight infection and diseases.
|
|
(lim-fo-SIT-ik)
| |
Referring to lymphocytes, a type of white blood cell. |
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| |
A type of cancer in which the bone marrow makes too many lymphocytes (white blood cells). |
|
(LIM-fo-EP-ih-THEE-lee-O-ma)
| |
A type of cancer that begins in the tissues covering the nasopharynx (the upper part of the throat behind the nose). |
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| |
An x-ray study of lymph nodes and lymphatic vessels made visible by the injection of a special dye. |
|
(LIM-foyd)
| |
Referring to lymphocytes, a type of white blood cell. Also refers to tissue in which lymphocytes develop. |
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| |
A white blood cell that is stimulated in a laboratory to kill tumor cells. Also called an LAK cell. |
|
(lim-FO-ma)
| |
Cancer that begins in cells of the immune system.
There are two basic categories of lymphomas. One kind is Hodgkin's
lymphoma, which is marked by the presence of a type of cell called the
Reed-Sternberg cell. The other category is non-Hodgkin's lymphomas, which
includes a large, diverse group of cancers of immune system cells.
Non-Hodgkin's lymphomas can be further divided into cancers that have an
indolent (slowly progressing) course and those that have an aggressive
(rapidly progressing) course. These subtypes behave and respond to
treatment differently. Both Hodgkin's and non-Hodgkin's lymphomas can occur
in children and adults, and prognosis and treatment depend on the stage and
the type of cancer.
|
|
| |
Destructive growth of lymph cells, usually involving the lungs, skin, kidneys, and central nervous system. Grades I and II are not considered cancerous, but grade III is considered a lymphoma. |
|
| |
A disease in which cells of the lymphatic system grow excessively. Lymphoproliferative disorders are often treated like cancer. |
|
| |
An obsolete term for a malignant tumor of lymphatic tissue. |
|
(lim-fo-sin-TIG-ruh-fee)
| |
A method used to identify the sentinel lymph node (the first draining lymph node near a tumor). A radioactive substance that can be taken up by lymph nodes is injected at the site of the tumor, and a doctor follows the movement of this substance on a computer screen. Once the lymph nodes that have taken up the substance are identified, they can be removed and examined to see if they contain tumor cells. |
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| |
An inherited disorder in which affected individuals have a higher-than-normal chance of developing colon cancer and certain other types of cancer, usually before the age of 60. Also called hereditary nonpolyposis colon cancer. |
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| |
In biology, lysis refers to the breakdown of a cell caused by damage to its plasma (outer) membrane. Lysis can be caused by chemical or physical means (for example, strong detergents or high-energy sound waves) or by an infection. |
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| |
A sac-like compartment inside a cell that has enzymes that can break down cellular components that need to be destroyed. |
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| |
Having to do with lysis. In biology, lysis refers to the disintegration of a cell by disruption of its plasma membrane. Lysis can be caused by chemical or physical means (e.g., high-energy sound waves) or by a virus infection. |
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| |
Destruction of an area of bone due to a disease process, such as cancer. |
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