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A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). |
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Recombinant tissue plasminogen activator. A protein that is made by the body and that helps dissolve blood clots. It can also be made in the laboratory and is used in the treatment of heart attack and stroke. It is also being studied in the treatment of cancer. r-tPA belongs to the family of drugs called systemic thrombolytic agents. Also called tissue plasminogen activator (tPA), Activase, and Alteplase. |
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A substance that is being studied for its ability to make cancer cells respond to drugs to which they have become resistant. It belongs to the family of drugs called multidrug resistance inhibitors. |
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An anticancer drug that inhibits the transformation of normal cells to cancer cells. It belongs to the family of drugs called enzyme inhibitors. Also called tipifarnib. |
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A disease of the nervous system caused by the rabies virus. Rabies is marked by an increase in saliva production, abnormal behavior, and eventual paralysis and death. |
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(ray-dee-AY-shun)
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Energy released in the form of particles or electromagnetic waves. Common sources of radiation include radon gas, cosmic rays from outer space, and medical x-rays. |
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(ray-dee-AY-shun fye-BRO-sis)
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The formation of scar tissue as a result of radiation therapy. |
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A health professional who specializes in caring for people who are receiving radiation therapy. |
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(ray-dee-AY-shun on-KOL-o-jist)
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A doctor who specializes in using radiation to treat cancer. |
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A person who makes sure that the radiation machine delivers the right amount of radiation to the correct site in the body. The physicist works with the radiation oncologist to choose the treatment schedule and dose that has the best chance of killing the most cancer cells. |
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A radiation therapy technique that delivers radiation directly to the tumor while sparing the healthy tissue. Also called radiosurgery and stereotactic external beam irradiation. |
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A health professional who gives radiation treatment. |
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(ray-dee-AY-shun THER-ah-pee)
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The use of high-energy radiation from x-rays, gamma rays, neutrons, and other sources to kill cancer cells and shrink tumors. Radiation may come from a machine outside the body (external-beam radiation therapy), or it may come from radioactive material placed in the body near cancer cells (internal radiation therapy, implant radiation, or brachytherapy). Systemic radiation therapy uses a radioactive substance, such as a radiolabeled monoclonal antibody, that circulates throughout the body. Also called radiotherapy. |
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(RAD-ih-kal sis-TEK-toe-mee)
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Surgery to remove the bladder as well as nearby tissues and organs. |
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Surgery to remove the uterus, cervix, and part of the vagina. The ovaries, fallopian tubes, and nearby lymph nodes may also be removed. |
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A surgical procedure to remove most or all of the lymph nodes that drain lymph from the area around a tumor. The lymph nodes are then examined under a microscope to see if cancer cells have spread to them. |
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(RAD-ih-kul mas-TEK-toe-mee)
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Surgery for breast cancer in which the breast, chest muscles, and all of the lymph nodes under the arm are removed. For many years, this was the breast cancer operation used most often, but it is used rarely now. Doctors consider radical mastectomy only when the tumor has spread to the chest muscles. Also called the Halsted radical mastectomy. |
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(RAD-ih-kul neh-FREK-toe-mee)
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Surgery to remove an entire kidney, nearby adrenal gland and lymph nodes, and other surrounding tissue. |
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(RAD-ih-kul peh-ri-NEE-al pros-ta-TEK-toe-mee)
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Surgery to remove all of the prostate through an incision between the scrotum and the anus. Nearby lymph nodes are sometimes removed through a separate incision in the wall of the abdomen. |
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(RAD-ih-kal pros-ta-TEK-toe-mee)
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Surgery to remove the entire prostate. The two types of radical prostatectomy are retropubic prostatectomy and perineal prostatectomy. |
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(RAD-ih-kul re-tro-PYOO-bik pros-ta-TEK-toe-mee)
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Surgery to remove all of the prostate and nearby lymph nodes through an incision in the wall of the abdomen. |
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(RAY-dee-o-AK-tiv)
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A drug containing a radioactive substance that is used in the diagnosis and treatment of cancer and in pain management of bone metastases. Also called a radiopharmaceutical. |
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(RAY-dee-o-AK-tiv)
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Airborne radioactive particles that fall to the ground during and after an atomic bombing, nuclear weapons test, or nuclear plant accident. |
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(RAY-dee-o-AK-tiv EYE-uh-dine)
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A radioactive form of iodine, often used
for imaging tests or as a treatment for thyroid cancer and certain other cancers. For imaging tests, the patient takes a small dose of radioactive iodine that collects in thyroid cells and certain kinds of tumors and can be detected by a scanner. For treatment of thyroid cancer, the patient takes a large dose of radioactive iodine, which kills thyroid cells. Radioactive iodine is also used in internal radiation therapy for prostate cancer, intraocular (eye) melanoma, and carcinoid tumors. The radioactive iodine is given by infusion or sealed in seeds, which are placed in or near the tumor to kill cancer cells.
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A radioactive form of palladium (a metallic element that resembles platinum). When used to treat prostate cancer, radioactive seeds (small pellets that contain radioactive palladium) are placed in the prostate. Cancer cells are killed by the energy given off as the radioactive material decays (breaks down). |
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A small, radioactive pellet that is placed in or near a tumor. Cancer cells are killed by the energy given off as the radioactive material decays (breaks down). |
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The use of electrodes to heat and destroy abnormal tissue. |
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A procedure that uses radiolabeled substances to detect tumors for surgical removal. |
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Treatment with a radioactive substance that is linked to an antibody that will attach to the tumor when injected into the body. |
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An unstable element that releases radiation as it breaks down. Radioisotopes can be used in imaging tests or as a treatment for cancer. |
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Any compound that has been joined with a radioactive substance. |
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A test that uses radiation or other imaging procedures to find signs of cancer or other abnormalities. |
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(RAY-dee-OL-o-jist)
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A doctor who specializes in creating and interpreting pictures of areas inside the body. The pictures are produced with x-rays, sound waves, or other types of energy. |
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The use of radiation (such as x-rays) or other imaging technologies (such as ultrasound and magnetic resonance imaging) to diagnose or treat disease. |
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A test that produces pictures (scans) of internal parts of the body. The person is given an injection or swallows a small amount of radioactive material; a machine called a scanner then measures the radioactivity in certain organs. |
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A drug containing a radioactive substance that is used in the diagnosis and treatment of cancer and in pain management of bone metastases. Also called a radioactive drug. |
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The use of a drug that makes tumor cells more sensitive to radiation therapy. |
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A drug that makes tumor cells more sensitive to radiation therapy. |
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A radiation therapy technique that delivers radiation directly to the tumor while sparing the healthy tissue. Also called radiation surgery and stereotactic external beam irradiation. |
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(RAY-dee-o-THER-a-pee)
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The use of high-energy radiation from x-rays, gamma rays, neutrons, and other sources to kill cancer cells and shrink tumors. Radiation may come from a machine outside the body (external-beam radiation therapy), or it may come from radioactive material placed in the body near cancer cells (internal radiation therapy, implant radiation, or brachytherapy). Systemic radiotherapy uses a radioactive substance, such as a radiolabeled monoclonal antibody, that circulates throughout the body. Also called radiation therapy. |
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(RAY-don)
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A radioactive gas that is released by uranium, a substance found in soil and rock. Breathing in too much radon can damage lung cells and lead to lung cancer. |
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A drug that belongs to the family of drugs called selective estrogen receptor modulators (SERMs) and is used in the prevention of osteoporosis in postmenopausal women. Raloxifene is also being studied as a cancer prevention drug. |
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An anticancer drug that stops tumor cells from growing by blocking the ability of cells to make DNA. Also called ICI D1694. It belongs to the family of drugs called thymidylate synthase inhibitors. |
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When referring to an experiment or clinical trial, the
process by which animal or human subjects are assigned by chance to separate
groups that compare different treatments or other interventions.
Randomization gives each participant an equal chance of being assigned to
any of the groups.
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A study in which the participants are assigned by chance to separate groups that compare different treatments; neither the researchers nor the participants can choose which group. Using chance to assign people to groups means that the groups will be similar and that the treatments they receive can be compared objectively. At the time of the trial, it is not known which treatment is best. It is the patient's choice to be in a randomized trial. |
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A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called ribonuclease enzymes. Also called OnconaseĀ®. |
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A drug used to help prevent the body from rejecting organ and bone marrow transplants. It is also being studied as a treatment for cancer. Rapamycin belongs to the family of drugs called immunosuppressants. It is now called sirolimus. |
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A procedure in which drugs that block the production of male hormones are alternated with male hormones and/or drugs that promote the production of male hormones. This procedure is being studied in the treatment of prostate cancer. |
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An opioid that relieves pain quickly. |
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A gene that has been found to cause cancer when it is altered (mutated). Agents that block its activity may stop the growth of cancer. A ras peptide is a protein fragment produced by the ras gene. |
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A drug that is used to treat high blood levels of uric acid in patients receiving treatment for cancer. |
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Cimicifuga racemosa. An eastern North American perennial herb. A substance obtained from the root of the plant has been used in some cultures to treat a number of medical problems. It is being studied in the treatment of hot flashes and other symptoms of menopause. The plant is also called black cohosh, black snakeroot, bugwort, and bugbane. |
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A substance being studied in the treatment of infections caused by fungi. It belongs to the family of drugs called antifungal agents. |
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Red blood cell. RBCs carry oxygen to all parts of the body. |
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An anticancer drug that belongs to the family of drugs called antineoplastic antibiotics. |
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A molecule inside or on the surface of a cell that binds to a specific substance and causes a specific physiologic effect in the cell. |
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Made through genetic engineering, which is also called gene splicing or recombinant DNA technology. By putting animal or plant genes into the genetic material of bacteria or yeast cells, these microorganisms can be turned into "factories" to make proteins for medical uses. |
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r-tPA. A protein that is made by the body and that helps dissolve blood clots. It can also be made in the laboratory and is used in the treatment of heart attack and stroke. It is also being studied in the treatment of cancer. r-tPA belongs to the family of drugs called systemic thrombolytic agents. Also called tissue plasminogen activator (tPA), Activase, and Alteplase. |
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A doctor who can surgically reshape or rebuild (reconstruct) a part of the body, such as a woman's breast after surgery for breast cancer. |
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Surgery that is done to reshape or rebuild (reconstruct) a part of the body changed by previous surgery. |
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By or having to do with the rectum. The rectum is the last several inches of the large intestine and ends at the anus. |
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The last several inches of the large intestine. The rectum ends at the anus. |
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The return of cancer, at the same site as the original (primary) tumor or in another location, after the tumor had disappeared. |
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Cancer that has returned after a period of time during which the cancer could not be detected. The cancer may come back to the same site as the original (primary) tumor or to another place in the body. |
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RBC. A cell that carries oxygen to all parts of the body. Also called an erythrocyte. |
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Trifolium pratense. A plant whose flowers have been used in some cultures to treat certain medical problems. It is being studied in the relief of menopausal symptoms and may have anticancer effects. Also called purple clover and wild clover. |
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The fruit of the jujube plant. It has been used in some cultures to treat certain medical problems. |
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Ulmus fulva or Ulmus rubra. The inner bark of this plant has been used in some cultures to treat certain medical problems. It may have antioxidant effects. Also called slippery elm, gray elm, Indian elm, and sweet elm. |
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A type of cell that appears in people with Hodgkin's disease. The number of these cells increases as the disease advances. |
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The term used when liquid backs up into the esophagus from the stomach. |
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In medicine, describes a disease or condition that does not respond to treatment. |
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Cancer that has not responded to treatment. |
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A treatment plan that specifies the dosage, the schedule, and the duration of treatment. |
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In oncology, describes the body area right around a tumor. |
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Refers to cancer that has grown beyond the original (primary) tumor to nearby lymph nodes or organs and tissues. |
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(kee-mo-THER-a-pee)
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Treatment with anticancer drugs directed to a specific area of the body.
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Inflammation of the intestines, but usually only of the small intestine. Regional enteritis increases the risk for developing colon cancer. Also called Crohn's disease. |
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In oncology, a lymph node that drains lymph from the region around a tumor. |
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A surgical procedure to remove some of the lymph nodes that drain lymph from the area around a tumor. The lymph nodes are then examined under a microscope to see if cancer cells have spread to them. |
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A decrease in the size of a tumor or in the extent of cancer in the body. |
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A health care professional who helps people recover from an illness or injury and return to daily life. Examples of rehabilitation specialists are physical therapists and occupational therapists. |
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The return of signs and symptoms of cancer after a period of improvement. |
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A specific measurement of survival. For cancer, the rate is calculated by adjusting the survival rate to remove all causes of death except cancer. The rate is determined at specific time intervals, such as 2 years and 5 years after diagnosis. |
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A method used to reduce tension and anxiety, and control pain. |
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A decrease in or disappearance of signs and symptoms of cancer. In partial remission, some, but not all, signs and symptoms of cancer have disappeared. In complete remission, all signs and symptoms of cancer have disappeared, although cancer still may be in the body. |
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The initial chemotherapy a person receives to bring about a remission. |
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A type of internal radiation treatment in which the radioactive source is removed between treatments. Also called high-dose-rate remote brachytherapy or high-dose-rate remote radiation therapy. |
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The main blood vessel that supplies blood to a kidney and its nearby adrenal gland and ureter. There is a renal artery for each kidney. |
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The fibrous connective tissue that surrounds each kidney. |
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The most common type of kidney cancer. It begins in the lining of the renal tubules in the kidney. The renal tubules filter the blood and produce urine. Also called hypernephroma. |
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The last part of a long, twisting tube that collects urine from the nephrons (cellular structures in the kidney that filter blood and form urine) and moves it into the renal pelvis and ureters. Also called collecting duct. |
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A fibrous envelope of tissue that surrounds the kidney. Also called Gerota's fascia and Gerota's capsule. |
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A tiny, round cluster of blood vessels within the kidneys. It filters the blood to reabsorb useful materials and remove waste as urine. |
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The area at the center of the kidney. Urine collects here and is funneled into the ureter, the tube that connects the kidney to the bladder. |
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(REE-nal TOO-bu-lar as-ih-DO-sis)
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A rare disorder in which structures in the kidney that filter the blood are impaired, producing urine that is more acid than normal. |
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To make a copy or duplicate of something. |
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In biology, refers to the reproduction cycle of viruses. A repliction cycle begins with the infection of a host cell and ends with the release of mature progeny virus particles. |
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An egg or sperm cell. Each mature reproductive cell carries a single set of 23 chromosomes. |
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In women, this system includes the ovaries, the fallopian tubes, the uterus (womb), the cervix, and the vagina (birth canal). The reproductive system in men includes the prostate, the testes, and the penis. |
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(ree-SEK-tuh-bull)
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Part or all of an organ that can be removed with surgery. |
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Surgical removal of part or all of an organ. |
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(ree-SEK-shun)
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Removal of tissue or part or all of an organ by surgery. |
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Cancer cells that remain after attempts to remove the cancer have been made. |
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Failure of a cancer to shrink after treatment. |
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A process in which a substance, such as tissue, is lost by being destroyed and then absorbed by the body. |
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RSV. A virus that causes respiratory infections with cold-like symptoms. |
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(RES-pih-ra-tor-ee)
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The organs that are involved in breathing. These include the nose, throat, larynx, trachea, bronchi, and lungs.
Also known as the respiratory tract. |
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(RES-pih-ra-tor-ee)
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Exercises and treatments that help improve or restore lung function. |
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The organs that are involved in breathing. These include the nose, throat, larynx, trachea, bronchi, and lungs. Also known as the respiratory system. |
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In medicine, an improvement related to treatment. |
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The percentage of patients whose cancer shrinks or disappears after treatment. |
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In biology, refers to a cell that is not dividing. |
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An eye cancer that most often occurs in children younger than 5 years. It occurs in hereditary and nonhereditary (sporadic) forms. |
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Vitamin A or a vitamin A-like compound. |
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Vitamin A. It is essential for proper vision and healthy skin and mucous membranes. Retinol is being studied for cancer prevention; it belongs to the family of drugs called retinoids. |
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A drug being studied in cancer prevention. It belongs to the family of drugs called retinoids. |
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(RET-row-PAIR-ih-toe-NEE-ul)
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Having to do with the area outside or behind the peritoneum (the tissue that lines the abdominal wall and covers most of the organs in the abdomen). |
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(re-tro-PYOO-bik pros-ta-TEK-toe-mee)
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Surgery to remove the prostate through an incision made in the abdominal wall. |
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Looking back at events that have already taken place. |
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A research study in which the medical records of groups of individuals who are alike in many ways but differ by a certain characteristic (for example, female nurses who smoke and those who do not smoke) are compared for a particular outcome (such as lung cancer). Also called a historic cohort study. |
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A study that compares two groups of people: those with
the disease or condition under study (cases) and a very similar group of
people who do not have the disease or condition (controls). Researchers
study the medical and lifestyle histories of the people in each group to
learn what factors may be associated with the disease or condition. For
example, one group may have been exposed to a particular substance that the
other was not. Also called a case-control study.
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RNA from a virus that is used to insert genetic material into cells. |
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A type of virus that has RNA instead of DNA as its genetic
material. It uses an enzyme called reverse transcriptase to become part of
the host cellsā DNA. This allows many copies of the virus to be made in the
host cells. The virus that causes AIDS, the human immunodeficiency virus
(HIV), is a type of retrovirus. |
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An antiviral gene being studied for treatment of cancer in patients who have HIV, the virus that causes AIDS. |
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A malignant tumor of either the central nervous system (CNS) or the kidney. Malignant rhabdoid tumors of the CNS often have an abnormality of chromosome 22. These tumors usually occur in children younger than 2 years. |
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A malignant tumor of muscle tissue. |
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A group of disorders marked by inflammation or pain in the connective tissue structures of the body. These structures include bone, cartilage, and fat. |
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A thin lighted tube used to examine the nose. Also called a nasoscope. |
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A procedure in which a thin, lighted tube is inserted into the nose to look for abnormal areas. Also called nasoscopy. |
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An anticancer drug isolated from a fungus. It is similar to the family of drugs called vinca alkaloids. |
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Rheum palmatum or Rheum officinale. The root of this plant has been used in some cultures to treat certain medical problems. It may have anti-inflammatory and anticancer effects. Also called da-huang, Chinese rhubarb, Indian rhubarb, and Turkish rhubarb. |
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A drug used to treat respiratory syncytial virus (RSV) infection in the lungs. |
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RNA. One of the two types of nucleic acids found in all cells. The other is deoxyribonucleic acid (DNA). Ribonucleic acid transmits genetic information from DNA to proteins produced by the cell.
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A family of anticancer drugs that interfere with the growth of tumor cells by blocking the formation of deoxyribonucleotides (building blocks of DNA). |
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A drug that is used to treat infections caused by bacteria. It belongs to the family of
drugs called antibiotics. |
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(ris-ED-roe-nate)
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A substance that is being studied in the prevention and treatment of osteoporosis. It belongs to the family of drugs called bone resorption inhibitors. |
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Something that may increase the chance of developing a
disease. Some examples of risk factors for cancer include age, a family
history of certain cancers, use of tobacco products, certain eating habits,
obesity, exposure to radiation or other cancer-causing agents, and certain
genetic changes. |
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A drug that belongs to the family of drugs called protease inhibitors. It interferes with the ability of a virus to make copies of itself. |
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A type of monoclonal antibody used in cancer detection or therapy. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells. |
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A substance that is being studied in the prevention of oral mucositis in patients receiving radiation therapy or chemotherapy for head and neck cancer. |
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A substance that is being studied for its ability to help other drugs reach the brain. It belongs to the family of drugs called bradykinin agonists. Also called lobradimil. |
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Ribonucleic acid. One of the two types of nucleic acids found in all cells. The other is deoxyribonucleic acid (DNA). RNA transmits genetic information from DNA to proteins produced by the cell.
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An anticancer drug that may prevent cancer cells from dividing. |
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A substance that is being studied in the treatment of anemia in patients who are receiving chemotherapy. It is a form of erythropoietin (a substance produced in the kidneys that stimulates the production of red blood cells) that has been changed in the laboratory. Also called methoxypolyethylene glycol epoetin beta. |
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A substance used for pain relief that is also being studied for its ability to prevent cancer and to block the growth of new blood vessels to solid tumors. It belongs to the family of drugs called nonsteroidal anti-inflammatory drugs. |
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A drug taken to help reduce the amount of sugar in the blood. Rosiglitazone helps make insulin more effective and improves regulation of blood sugar. It belongs to the family of drugs called thiazolidinediones. |
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A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called angiogenesis inhibitors. |
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A drug that belongs to the family of anticancer drugs called taxanes. |
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A drug that may increase the effectiveness of radiation therapy. Also called efaproxiral. |
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Respiratory syncytial virus. A virus that causes respiratory infections with cold-like symptoms. |
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