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Bench-to-Bedside Awards

FY 2004 Bench-to-Bedside Proposals

ICs Project/Investigator
NIAMS
NINDS
"Neural substrates underlying motor control of a newly implanted hand transplant"
PIs: L. Cendales, MD, NIAMS; L. Cohen, MD, NINDS
NIEHS
NCI
NICHD
CC
"Development of Non-invasive treatment for uterine leiomyoma (fibroids)"
PIs: Dr. B. Davis, NIEHS; Dr. J. Segar, NICHD; Dr. Pam Stratton, NICHD
AIs: from CC, NCI, NICHD
NIDDK
NCI
ORS
"Infrared and Near Infrared Image Guided Minimally Invasive Assessment of Renal Perfusion during Donor Nephrectomies and Partial Nephrectomies"
PIs: E. Elster, MD, NIDDK; A. Kirk, MD, PhD, NIDDK
AIs: from NCI and ORS
NCI
NIDCD
"Novel Approach for treatment of squamous cell malignancies with 17-AAG and bortezomib"
PIs: D. Gius, MD, PhD, NCI; C. VanWaes, MD, PhD, NIDCD
AI: L. Neckers, PhD, NCI
CC
NHLBI
"Therapeutic application of intravascular nitrite for sickle cell disease"
PIs: M. Gladwin, MD, CC; R. Cannon, MD, NHLBI
AIs: from CC, NIDDK, NHLBI
NIMH
NIAAA
"Intermediate phenotype and genetic mechanisms for psychosis and cognitive disturbance in 22q11.2-hemideletion syndrome"
PIs: A. Meyer-Lindenberg, MD,PhD, NCI; D. Goldman, MD, NIAAA
AIs: from NIMH
NHLBI
NCI
"Molecular profiling of response to proteasome inhibition by bortezomib (PS341) in a clinical trial of mantle cell lymphoma"
PIs: A. Wiestner, MD,PhD, NHLBI; W. Wilson, MD,PhD, NCI
AIs: from NCI
NEI
NCI
"A Phase I/II pilot study to evaluate the treatment of intraocular lymphoma with BL22 immunotoxin"
PIs: R. Nussenblatt, MD, NEI; I. Pastan, MD, NCI
AIs: from NEI and NCI
NHLBI
VRC
NCI
"Immunotherapy for Myelodysplastic Syndrome"
PIs: A.J. Barrett, MD, HB, NHLBI; D. Douek, MD, PhD, VRC, NIAID; S. Rosenberg, MD, PhD, NCI
AIs: from NHLBI,VRC,NIAID
NHGRI
CC (Pharmacy)
"A Phase I Treatment Trial of the Circadian Sleep Disturbance in Smith-Magenis Syndrome (SMS)"
PIs: Ann Smith, MA, DSc, MGB, NHGRI; G. Grimes, BS, CC Pharm
AIs: from NIMH, NHGRI, NEI, USUHS
NIAID
NHLBI
"Pre-clinical non-human primate studies of an invo selectable vector intended for use in a planned clinical trial of gene therapy for chronic granulomatous disease"
PIs: H. Malech, MD, LHD, NIAID; C. Dunbar, MD, HB, NHLBI
AIs: from NIAID, NHLBI
CC/CCMD
CIT
"Isolation and Characterization of Circulating Endothelial Cells in Primary Pulmonary Hypertension: Implications for Early Diagnosis and Novel Therapeutic Targets"
PIs: M. Solomon, MD, CCMD, CC; R. Danner, MD, CCMD, CC
AIs: from CIT and NHLBI
NINDS
NCI
"Evaluation of the anti-IL-2/IL-15Rb monoclonal antibody Hu MiK-b-1 in a therapeutic trial in patients with HAM/TSP and a test of hypotheses concerning the role of IL-15 in the maintenance of CD8+ memory T-cells and in the pathogenesis of HAM/TSP"
PIs: T. Waldmann, MD, MB, NCI; S. Jacobson, PhD, NINDS
AI: T. Fleisher, MD, CC
NCI
NHGRI
"Childhood Cancer and Plexiform Neurofibroma Tissue Microarray for Molecular Target Screening and Clinical Drug Development"
PIs: E. Fox, MD, NCI; K. Baird, MD, NHGRI
AI: from NCI, NHGRI, and Pediatric Phase I/Pilot Consortium
NCI
NHGRI
"Molecular profiling and drug discovery for patients with PTEN Hamartomatous Tumor Syndromes (PHTS)"
PIs: P. Dennis, MD,PhD, NCI; A. Elkahoun, PhD, NHGRI
AIs: from NCI
VRC/NIAID
NCI
"Assessing the safety and immunogenicity of a therapeutic vaccination strategy using a DNA plasmid vaccine prime and a recombinant adenovector boost in HIV infected adults"
PIs: B. Graham, MD, PhD, VRC/NIAID; R. Koup, MD, VRC/NIAID
AIs: from VRC/NIAID and NCI
NCI
NIAID
"Targeting vascular endothelial growth factor-A (VEGF-A) and receptor-2 (VEGFR-2) for the treatment of Primary Effusion Lymphoma"
PIs: G. Tosato, MD, NCI; R. Yarchoan, MD, NCI
AIs: from NCI and NIAID
NCI
NINDS
"Pediatric NeuroAIDS in the HAART Era: Identification of Disease Markers and Therapeutic Targets"
PIs: R. Hazra, MD, HAMB, NCI; E. Major, PhD, LMMN, NINDS; L. Schwartz, MD, LMMN, NINDS
AIs: from NCI, NINDS, CNMC
NCI
NIAID
"Treatment of Primary-Effusion Lymphoma with Combination Virolytic and Cytotoxic Chemotherapy"
PIs: R. Yarchoan, MD, NCI; J. Cohen, MD, NIAID; R. Little, MD, NCI
AIs: from NCI

 

Past Proposals:

1999 Proposals
2000 Proposals
2001 Proposals
2002 Proposals
2003 Proposals


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