Skip to main content
NIH Clinical Center
  Home | Contact Us | Site Map | Search
About the Clinical Center
For Researchers and Physicians
Participate in Clinical Studies

Back to: Clinical Center Home Page > For Researchers and Physicians > Training
 
Principles of Clinical Pharmacology

The course in Principles of Clinical Pharmacology is based on a series of lectures that cover much of the scientific basis of the bridging discipline of clinical pharmacology. Formal lectures will be supplemented by syllabus material and self-study exercises prepared by the course faculty.

The course is an integral part of the ClinPRAT NIH intramural clinical pharmacology training program and is meant to complement the Clinical Center's course on Introduction to the Principles and Practice of Clinical Research .

Since most medical schools lack a formal course in clinical pharmacology, this course is also designed to assist individuals preparing to take the certifying examinations of the American Board of Clinical Pharmacology and to meet the needs of researchers who have an interest in the clinical pharmacologic aspects of contemporary drug development and utilization.

The course provides an introductory review of pharmacokinetics, drug metabolism and transport, assessment of drug effects, drug therapy in special populations, and contemporary drug development. The course is offered yearly at the NIH Warren Grant Magnuson Clinical Center and runs from September through April, one evening a week.

The course is open to all interested persons without charge.

Register Online

    For additional information and registration information, contact:

    Donna L. Shields
    ClinPRAT Program Coordinator,
    NIH Clinical Center
    Office of Clinical Research Training and Medical Education
    10 Center Drive
    MSC 1165, Room 1C227
    Bethesda, MD 20892-1165

    Telephone:  Fax:

     (301) 435-6618

    (301) 480-7307

    E-mail: DShields@mail.cc.nih.gov

     

All sessions will meet Thursday evenings from 6:30 p.m. to approximately 7:45 p.m.
NIH Clinical Center
Building 10, Lipsett Amphitheater
10 Center Drive
Bethesda, Maryland 20892

Directions to the NIH Clinical Center

Faculty Biosketches

 

Video files for modules listed below require RealPlayer software and 220Kbps LAN or 56Kbps dial-up bandwidth.NIH staff can download RealOne Enterprise Desktop for Windows or RealOne for Mac. Viewers outside the NIH network can download the latest free version of RealPlayer software from Real Networks

September 2 Introduction to course

Video with Caption
Video without Caption
A. Atkinson


MODULE 1: PHARMACOKINETICS

 September 9 Clinical pharmacokinetics

Video with Caption
Video without Caption
 A. Atkinson
 September 16 Compartmental analysis of drug distribution

Video with Caption
Video without Caption
 A. Atkinson
 September 23 Drug absorption and bioavailability

Video with Caption
Video without Caption
 A. Atkinson
 September 30 Effects of renal disease on pharmacokinetics

Video with Caption
Video without Caption
 A. Atkinson
 October 7 Pharmokinetics in patients requiring renal replacement therapy

Video with Caption
Video without Caption

- Dr. Atkinson's slides
- Dr. Susla's slides

 A. Atkinson
 G. Susla
 October 14 Effects of liver disease on pharmacokinetics

Video with Caption
Video without Caption
 A. Atkinson
 October 21 Noncompartmental vs. compartmental approaches to PK analysis

Video with Caption
Video without Caption
 D. Foster
 October 28 Distributed models of drug kinetics

Video with Caption
Video without Caption
 P. Morrison
 November 4 Population pharmacokinetics

Video with Caption
Video without Caption
 R. Miller


MODULE 2: DRUG METABOLISM AND TRANSPORT

 November 18 Pathways of drug metabolism

Video with Caption
Video without Caption
 S. Markey
 December 2 Chemical assay of drugs and drug metabolites

Video with Caption
Video without Caption
 S. Markey
 December 9 Pharmacogenetics

Video with Caption
Video without Caption
 D. Flockhart
 December 16 Drug interactions

Video with Caption
Video without Caption
 Dr. Penzak
 January 6 Biochemical mechanisms of drug toxicity

Video with Caption
Video without Caption
 L. Pohl
 January 13 Equilibrative and cocentrative transport

Video with Caption
Video without Caption
 P. Preusch
 January 20 SPECIAL LECTURE:
P-glycoprotein and drug transport

Video with Caption
Video without Caption
 M. Gottesman


MODULE 3: ASSESSMENT OF DRUG EFFECTS:

 January 27 Dose response and concentration response analysis

Video with Caption
Video without Caption
 F. Balis
February 3 Physiological and laboratory markers of drug effect
- Dr. Atkinson's slides
- Dr. Figg's slides

Video with Caption
Video without Caption
 A.Atkinson
 W. Figg
 February 10 Disease progression models and clinical trial simulation

Video with Caption
Video without Caption
 D. Mould


MODULE 4: Optimizing and Evaluating Patient Therapy

 February 17 Drug therapy in pregnant and nursing women

Video with Caption
Video without Caption
 M. Frederiksen
 February 24 Developmental pharmacology

Video with Caption
Video without Caption
 F.Balis
 March 3 Drug therapy in the elderly

Video with Caption
Video without Caption
 D.Abernethy
 March 10 Clinical analysis of adverse drug reactions

Video with Caption
Video without Caption
 K. Calis
 March 17 Quality assessment of drug therapy

Video with Caption
Video without Caption
 C. Daniels


MODULE 5: DRUG DISCOVERY AND DEVELOPMENT

March 24 Drug Discovery
- Dr. Gorman's slides
- Dr. Sausville's slides

Video with Caption
Video without Caption
 E. Sausville
 March 31 Pre-clinical development

Video with Caption
Video without Caption
  C. Takimoto
 April 7 Animal scale up and Phase I studies
- Dr. Collin's slides
- Dedrick's slides

Video with Caption
Video without Caption
  J. Collins
  R. Dedrick
 April 14 Pharmacokinetics of biotechnology products and large molecules

Video with Caption
Video without Caption
  P. Garzone
 April 21
Design of clinical drug development programs
- Dr. Grudzinskas' slides

Video with Caption
Video without Caption

- Dr. Atkinson's slides
(Due to the size of the images, download may take several minutes.)

Video with Caption
Video without Caption
C.Grudzinskas
 April 28 Role of the FDA in guiding drug development

Video with Caption
Video without Caption
  C. Peck

Principles of Clinical Pharmacology - Scanned image of the book cover

Picture of a clinical pharmacologist receiving her certficate of course completion.

Denotes Real Systems streaming video available for users with real player and a connection of speed 56k or greater.


For information on this program, contact Donna L. Shields, ClinPRAT Program Coordinator, DShields@mail.cc.nih.gov For information on the Clinical Center, contact OCCC@mail.cc.nih.gov

Office of the Director, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland

Top | ClinPRAT | CC | NIH
This page last reviewed December 11, 2003

National Institutes
of Health
  Department of Health
and Human Services
 
NIH Clinical Center National Institutes of Health