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Medications Development: Drug Discovery, Databases, and Computer-Aided Drug Design |
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NIDA Research Monograph, Number 134 [Printed in 1993]If you have the Acrobat reader plug-in for Netscape or Internet Explorer click on the document link and you will be able to view and/or print out the pages. If you have trouble viewing the document in your browser window, download the document (Windows users - right click on the link and Save as...) to your computer and get Adobe Acrobat Reader (free) in order to view it. This monograph is not available by chapter. The Table of Contents (below) is shown to assist in locating information prior to downloading the monograph. Table of Contents Strategies for Drug Discovery-----1 Mass Ligand-Binding Screening Strategies for Identification of Leads for New Drug Discovery-----37 Antibody- and Peptide Structure-Based Drug Design-----46 The Use of Cloned Human Receptors for Drug Design-----56 Synthetic Peptide Combinatorial Libraries May Be Used To Determine Peptide Ligands for Opioid Receptors-----66 Preparation of Large Peptide Libraries With One Peptide per Bead and Their Use for the Discovery of Peptides That Bind to Acceptors-----75 Computer Design of Bioactive Compounds Based on 3-D Properties of Ligands-----64 Toward the Design of New Inhibitors: A Computer Modeling Approach-----103 Efforts To Improve the Utilization of Protein Sequence and Structure Databases-----114 Use of Computer Graphics in Drug Design-----129 Purification and Cloning of Opioid Receptors-----146 Computer-Assisted Design of Dopamine Transporter Ligands-----165 The Pharmacophore for Opioid Activity-----178 The Molecular Basis of Opioid Potency and Selectivity: Morphiceptins, Dermorphins, Deltorphins, and Enkephalins-----195 Molecular Determinants of Cannabinoid Activity: Toward the Design of Cannabinoid Analgesics With Reduced Psychoactive Liability-----210 Cocaine Receptor: A Structure-Activity Relationship Study-----229 The Use of Conformational Restriction and Molecular Modeling Techniques in the Development of Receptor-Specific Opioid Peptide Agonists and Antagonists-----236 Probes for the Cannabinoid Sites of Action-----253 A Model for the Structural Basis of -Opiloid Receptor Selectivity-----266 List of NIDA Research Monographs-----281 |
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