NIDA - Research Monographs - Monograph 8: Rx :3 x /Week Laam Alternative to Methadone

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	Rx :3 x /Week Laam Alternative to Methadone

NIDA Research Monograph, Number 8 [Printed in 1976]

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Table of Contents

Foreword-----V
Robert L. DuPont, M.D.

Introduction-----1
Jack Blaine, M.D. and Pierre Renault, M.D.

The Chemistry of LAAM-----10
Sydney Archer, Ph.D.

PRECLINICAL STUDIES

Pharmacology of LAAM-----15
Sydney Archer, Ph.D.

Toxicology of LAAM-----29
Ms. Ann Wolven and Sydney Archer, Ph.D.

CLINICAL STUDIES

Phase I-----39
Ralph M. Sollod, M.S., and Marcia G. Goldstein, M.A.

Selected Clinical Studies Synopses-----52

Sumnary of Veterans Administration Phase II Cooperative Study for LAAM and Methadone-----94
Walter Ling, M.D. V. Charles Chamvastra, M.D. Samuel C. Kaim, M.D. C. James Klett, Ph.D.

Summary of SAODAP Phase II Cooperative Study of LAAM vs. Methadone-----103
Walter Ling, M.D. C. James Klett, Ph.D. Roderic D. Gillis

Phase III Clinical Study of Levo-Alpha-Acetylmethadol-----109
John A. Whysener, M.D., Ph.D.

The Use of LAAM in Treatment-----112
James Cooper, M.D.

A Clinical Experience with LAAM-----115
Avram Goldstein, M.D.

A LAAM Bibliography
Preclinical-----118
Clinical-----123

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