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Statistical Issues in Clinical Trials for Treatment of Opiate Dependence |
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NIDA Research Monograph, Number 128 [Printed in 1992]If you have the Acrobat reader plug-in for Netscape or Internet Explorer click on the document link and you will be able to view and/or print out the pages. If you have trouble viewing the document in your browser window, download the document (Windows users - right click on the link and Save as...) to your computer and get Adobe Acrobat Reader (free) in order to view it. This monograph is not available by chapter. The Table of Contents (below) is shown to assist in locating information prior to downloading the monograph. Download Monograph128.pdf - Statistical Issues in Clinical Trials for Treatment of Opiate Dependence (1.4 MB) Table of Contents Introduction-----1 Drug Dependence (Addiction) and Its Treatment-----6 Background and Design of a Controlled Clinical Trial (ARC 090) for the Treatment of Opioid Dependence-----14 Clinical Endpoints: Discussion Session-----25 Design of Clinical Trials for Treatment of Opiate Dependence: What Is Missing?-----29 Comments-----37 Rejoinder-----42 Summary of Discussion-----44 Efficacy of Urinalysis in Monitoring Heroin and Cocaine Abuse Patterns: Implications in Clinical Trials for Treatment of Drug Dependence-----46 Comments-----59 Summary of Discussion-----62 Open/Panel Discussion: Design Issues-----64 A Bayesian Nonparametric Approach to Analysis of Treatment for
Drug Dependence Data-----70 Three Estimators of the Probability of Opiate Use From Incomplete Data-----82 Summary of Discussion-----95 Issues in the Analysis of Clinical Trials for Opiate Dependence-----97 Summary of Discussion-----114 Analysis of Clinical Trials for Treatment of Opiate Dependence: What
Are the Possibilities?-----116 Summary of Discussion-----135 Toward a Dynamic Analysis of Disease-State Transition Monitored by
Serial Clinical Laboratory Tests-----137 Summary of Discussion-----158 A Markov Model for NIDA Data on Treatment of Opiate Dependence-----160 Summary of Discussion-----168 Open/Panel Discussion: Analysis Issues-----170 Open/Panel Discussion: General Issues-----176 List of Participants-----182 List of NIDA Research Monographs-----186 |
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