Highlights |
What are DDT, DDE, and DDD? |
What happens to DDT, DDE, and DDD when they
enter the environment? |
How might I be exposed to DDT, DDE, and DDD? |
How can DDT, DDE, and DDD affect my health? |
How likely are DDT, DDE, and DDD to cause
cancer? |
How can DDT, DDE, and DDD affect children? |
How can families reduce the risk of exposure
to DDT, DDE, and DDD? |
Is there a medical test to show whether I've
been exposed to DDT, DDE, and DDD? |
Has the federal government made recommendations to protect human health? |
References |
Contact Information |
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September 2002 |
ToxFAQs™ |
for |
DDT, DDE, and DDD |
(DDT,
DDE y DDD) |
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CAS#
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DDT 50-29-3 |
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DDE 72-55-9 |
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DDD 72-54-8 |
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This fact sheet answers the most frequently
asked health questions about DDT, DDE, and DDD. For more information,
you may call the ATSDR Information Center at 1-888-422-8737.
This fact sheet is one in a series of summaries about hazardous
substances and their health effects. This information is important
because this substance may harm you. The effects of exposure
to any hazardous substance depend on the dose, the duration,
how you are exposed, personal traits and habits, and whether
other chemicals are present.
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HIGHLIGHTS: Exposure to DDT,
DDE, and DDD occurs mostly from eating foods containing
small amounts of these compounds, particularly meat, fish
and poultry. High levels of DDT can affect the nervous
system causing excitability, tremors and seizures. In
women, DDE can cause a reduction in the duration of lactation
and an increased chance of having a premature baby. DDT,
DDE, and DDD have been found in at least 441 of the 1,613
National Priorities List sites identified by the Environmental
Protection Agency (EPA). |
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What
are DDT, DDE, and DDD? |
DDT (dichlorodiphenyltrichloroethane)
is a pesticide once widely used to control insects in agriculture
and insects that carry diseases such as malaria. DDT is a
white, crystalline solid with no odor or taste. Its use in
the U.S. was banned in 1972 because of damage to wildlife,
but is still used in some countries.
DDE (dichlorodiphenyldichloroethylene)
and DDD (dichlorodiphenyldichloroethane) are chemicals similar
to DDT that contaminate commercial DDT preparations. DDE has
no commercial use. DDD was also used to kill pests, but its
use has also been banned. One form of DDD has been used medically
to treat cancer of the adrenal gland.
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What
happens to DDT, DDE, and DDD when they enter the environment? |
- DDT entered the environment when it was used as a pesticide;
it still enters the environment due to current use in other
countries.
- DDE enters the environment as contaminant or breakdown
product of DDT; DDD also enters the environment as a breakdown
product of DDT.
- DDT, DDE, and DDD in air are rapidly broken down by sunlight.
Half of what's in air breaks down within 2 days.
- They stick strongly to soil; most DDT in soil is broken
down slowly to DDE and DDD by microorganisms; half the DDT
in soil will break down in 2-15 years, depending on the
type of soil.
- Only a small amount will go through the soil into groundwater;
they do not dissolve easily in water.
- DDT, and especially DDE, build up in plants and in fatty
tissues of fish, birds, and other animals.
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How
might I be exposed to DDT, DDE, and DDD? |
- Eating contaminated foods, such as root and leafy vegetable,
fatty meat, fish, and poultry, but levels are very low.
- Eating contaminated imported foods from countries that
still allow the use of DDT to control pests.
- Breathing contaminated air or drinking contaminated water
near waste sites and landfills that may contain higher levels
of these chemicals.
- Infants fed on breast milk from mothers who have been
exposed.
- Breathing or swallowing soil particles near waste sites
or landfills that contain these chemicals.
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How
can DDT, DDE, and DDD affect my health? |
DDT affects the nervous system. People
who accidentally swallowed large amounts of DDT became excitable
and had tremors and seizures. These effects went away after
the exposure stopped. No effects were seen in people who took
small daily doses of DDT by capsule for 18 months.
A study in humans showed that women who
had high amounts of a form of DDE in their breast milk were
unable to breast feed their babies for as long as women who
had little DDE in the breast milk. Another study in humans
showed that women who had high amounts of DDE in breast milk
had an increased chance of having premature babies.
In animals, short-term exposure to large
amounts of DDT in food affected the nervous system, while
long-term exposure to smaller amounts affected the liver.
Also in animals, short-term oral exposure to small amounts
of DDT or its breakdown products may also have harmful effects
on reproduction.
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How
likely are DDT, DDE, and DDD to cause cancer? |
Studies in DDT-exposed workers did not
show increases in cancer. Studies in animals given DDT with
the food have shown that DDT can cause liver cancer.
The Department of Health and Human Services
(DHHS) determined that DDT may reasonable be anticipated to
be a human carcinogen. The International Agency for Research
on Cancer (IARC) determined that DDT may possibly cause cancer
in humans. The EPA determined that DDT, DDE, and DDD are probable
human carcinogens.
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How
can DDT, DDE, and DDD affect children? |
There are no studies on the health effects
of children exposed to DDT, DDE, or DDD. We can assume that
children exposed to large amounts of DDT will have health
effects similar to the effects seen in adults. However, we
do not know whether children differ from adults in their susceptibility
to these substances.
There is no evidence that DDT, DDE, or
DDD cause birth defects in people. A study showed that teenage
boys whose mothers had higher DDE amounts in the blood when
they were pregnant were taller than those whose mothers had
lower DDE levels. However, a different study found the opposite
in preteen girls. The reason for the discrepancy between these
studies is unknown.
Studies in rats have shown that DDT and
DDE can mimic the action of natural hormones and in this way
affect the development of the reproductive and nervous systems.
Puberty was delayed in male rats given high amounts of DDE
as juveniles. This could possibly happen in humans. A study
in mice showed that exposure to DDT during the first weeks
of life may cause neurobehavioral problems later in life.
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How
can families reduce the risk of exposure to DDT, DDE, and DDD? |
- Most families will be exposed to DDT by eating food or
drinking liquids contaminated with small amounts of DDT.
- Cooking will reduce the amount of DDT in fish.
- Washing fruit and vegetables will remove most DDT from
their surface.
- Follow health advisories that tell you about consumption
of fish and wildlife caught in contaminated areas.
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Is
there a medical test to show whether I've been exposed to DDT,
DDE, and DDD? |
Laboratory tests can detect DDT, DDE,
and DDD in fat, blood, urine, semen, and breast milk. These
tests may show low, moderate, or excessive exposure to these
compounds, but cannot tell the exact amount you were exposed
to, or whether you will experience adverse effects. These
tests are not routinely available at the doctor's office because
they require special equipment.
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Has the federal government made recommendations to protect human health? |
The Occupational Safety and Health Administration
(OSHA) sets a limit of 1 milligram of DDT per cubic meter
of air (1 mg/m³) in the workplace for an 8-hour shift,
40-hour workweek.
The Food and Drug Administration (FDA)
has set limits for DDT, DDE, and DDD in foodstuff at or above
which the agency will take legal action to remove the products
from the market.
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References |
Agency for Toxic Substances and Disease
Registry (ATSDR). 2002. Toxicological
Profile for DDT, DDE, and DDD. Update. Atlanta,
GA: U.S. Department of Health and Human Services, Public Health
Service.
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Where can I get more information? |
ATSDR can tell you where to find occupational
and environmental health clinics. Their specialists can recognize,
evaluate, and treat illnesses resulting from exposure to hazardous
substances. You can also contact your community or state health
or environmental quality department if you have any more questions
or concerns. For more information, contact:
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Agency for Toxic Substances and Disease Registry
Division of Toxicology
1600 Clifton Road NE, Mailstop F-32
Atlanta, GA 30333
Phone: 1-888-42-ATSDR (1-888-422-8737)
FAX: (770)-488-4178
Email: ATSDRIC@cdc.gov
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