HomeResearchExtramural Research Genome Technology

Genome Technology

	Overview
	Program Information
	Reports
	Policies
	Funding Opportunities
	Advanced Sequencing Technology Awards
	Program Staff

Overview

The Genome Technology program supports research to develop new methods, technologies and instruments that enable rapid, low-cost determination of DNA sequence, SNP genotyping (variation), and functional genomics (broadly defined) experiments. Priorities include the refinement of current technologies to increase efficiency and decrease cost while maintaining or improving data quality, and the development of completely novel approaches to achieve orders-of-magnitude improvement. Integration of process steps is key to achieving these goals.

The program also supports and coordinates transfer of technology from developers to users, and promotes collaborative, multidisciplinary programs that closely integrate research projects at academic and industrial laboratories.

The involvement of The National Human Genome Research Institute (NHGRI) in BECON [becon.nih.gov], the trans-National Institutes of Health (NIH) Bioengineering Consortium, is through the Genome Technology program. The development of integrated concepts and tools for genomic research benefits from bioengineering research and methods. NHGRI supports bioengineering research through grants made in response to NHGRI program announcements and requests for application, and through NHGRI participation in BECON's bioengineering funding [becon.nih.gov] opportunities, such as the Bioengineering Research Grants (BRG) and Bioengineering Research Partnerships (BRP) programs.

Program Information

• Concept Papers for Two New DNA Sequencing Technology Development Programs

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Reports

• Sequencing Technology Workshop May 13, 1998.
• Sequencing Variation Workshop March 31-April 1, 1997.
• Functional Analysis Workshop December 2-3, 1997.

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Policies

• Principles and Guidelines for Recipients of NIH Research Grants and Contracts on Obtaining and Disseminating Biomedical Research Resources: Final Notice [ott.od.nih.gov]

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Funding Opportunities

RFA-HG-04-002 [grants.nih.gov]: Near-Term Technology Development for Genome Sequencing
This program supports development of novel technologies to substantially reduce the cost of genomic DNA sequencing. The current cost to sequence a mammalian-sized genome at the desired data quality is $10 to $50 million; the goal of this initiative is to reduce costs by at least two orders of magnitude.
Application Date: April 15, 2004. Expiration Date: October 15, 2004, unless reissued.

RFA-HG-04-003 [grants.nih.gov]: Revolutionary Genome Sequencing Technologies: The $1000 Genome
This program supports development of novel technologies that will enable extremely low-cost genomic DNA sequencing. The current cost to sequence a mammalian-sized genome at the desired data quality is $10 to $50 million; the goal of this initiative is to reduce costs by at least four orders of magnitude.
Application Date: April 15, 2004. Expiration Date: October 15, 2004, unless reissued

PA-97-044: Technologies for Genomic Mapping, Sequencing, and Analysis
This announcement solicits investigator-initiated proposals to develop new technologies.

PA-97-045: Pilot Projects or Feasibility Studies for Genomic Mapping, Sequencing and Analysis (R21)
This program supports technology development research for high-risk, high-payoff projects for which little or no preliminary data may be available. Support is for a maximum of two years at $100,000 direct costs per year.

PAR-02-021: Centers of Excellence in Genomic Science
The CEGS program supports multi-investigator, interdisciplinary teams to develop innovative genomic approaches to address a particular biological problem. A CEGS project will address a critical issue in genomic science, proposing a solution that would be a very substantial advance.

PAS-00-112 [grants.nih.gov]: Technologies for Closing DNA Sequence Gaps and Improving Methods for Obtaining the Sequence of Difficult-to-Sequence Regions.
The Human Genome Project sequencing centers have provided a list of clones that applicants may use, but this is not a requirement. These clones were either difficult to finish or contain gaps.

• Clone List 1
• Clone List 2
• Clone List 3

PAR-04-023 [grants.nih.gov]: Bioengineering Research Partnerships

PAR-02-011 [grants.nih.gov]: Bioengineering Research Grants

PA-03-058 [grants.nih.gov]: Exploratory/Developmental (R21) Bioengineering Research Grants (EBRG)

PA-01-049 [grants.nih.gov]: Single Molecule Detection and Manipulation

PA-01-050 [grants.nih.gov]: Single Molecule Detection and Manipulation - SBIR/STTR

PA-02-125 [grants.nih.gov]: SBIR Nanotechnology Initiative

PAR-03-045 [grants.nih.gov]: Nanoscience and Nanotechnology in Biology and Medicine

Small Business Funding Opportunities [grants.nih.gov]: Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) program information.

Expired Grant Solicitations

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Advanced Sequencing Technology Awards

In 2004, NHGRI initiated a coordinated effort to support the development of technologies to dramatically reduce the cost of DNA sequencing, a move aimed at broadening the applications of genomic information in medical research and health care.

• Awards Made in Fiscal Year 2004
• October 2004 News Release

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Program Staff

Program Directors
Jeffery Schloss, Ph.D.
E-mail: js173g@nih.gov

Bradley A. Ozenberger, Ph.D.
E-mail: bo37s@nih.gov

Mark Guyer, Ph.D.
E-mail: mg25m@nih.gov

Program Analyst
Allison Peck
E-mail: pecka@mail.nih.gov

Address
National Human Genome Research Institute
National Institutes of Health
5635 Fishers Lane
Suite 4076, MSC 9305
Bethesda, MD 20892-9305
Phone: (301) 496-7531
Fax: (301) 480-2770

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Last Updated: October 2004