Laboratory of Cell Signaling

Sue Goo Rhee, PhD, Chief

Laboratory of Cell Signaling Research in this laboratory is primarily concerned with (A) a transmembrane signaling cascade involving the hydrolysis of phosphatidylinositol 4,5-bisphosphate by phospholipase C (PLC) and (B) characterization of noble peroxidases which we discovered a number of years ago. Specific projects deal with mechanisms that couples various receptor functions to PLC isozymes and the role of hydrogen peroxide in cell signaling. The latter item is a long term goal that evolved from our conviction that the function of the newly discovered peroxidases is not only to eliminate deleterious peroxides generated during oxygen metabolism but perhaps also to modulate cell signaling by controlling the concentration of putative second messenger hydrogen peroxide.