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This review of risk factors for major mental disorders is based on longitudinal epidemiologic and clinic-based studies published since 1992. The review was recommended by the NIMH Longitudinal Research Study Group to help identify risk conditions that might be considered as potential targets for focused prevention efforts. The disorders covered are: Agoraphobia; Alcohol Use; Attention Deficit Hyperactivity Disorder; Autism; Bipolar Disorder; Conduct Disorder; Dementia; Depression—Child/Adolescent, Adult, Late-Life; Eating Disorders; Generalized Anxiety Disorder; Obsessive-Compulsive Disorder; Panic Disorder; Post-Traumatic Stress Disorder; Schizophrenia; Social Phobia; Suicide; and Substance Use Disorder. The review was done under the leadership of William Eaton, Ph.D., at the Johns Hopkins University Bloomberg School of Public Health, and Stephen Buka, Ph.D., at the Harvard School of Public Health, and was supported by supplements to NIMH grants MH47447 and MH50647.
The logic and format of meta analysis was used. Each chapter of the report covers a specific psychiatric disorder and includes evidence tables with key study characteristics, a bibliography, and forest plots charting the odds ratios shown for each risk factor across studies. The goal was to present study results in a common metric to facilitate comparison of results from multiple studies.
This review should be helpful to researchers in planning for intervention or prevention research.
The report, with chapters for each of the disorders, is available from http://apps1.jhsph.edu/weaton/MDRF/main.pdf
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