17. Integration of Behavioral and Relaxation Approaches Into the Treatment of Chronic Pain and Insomnia
National Institutes of Health
Technology Assessment Conference Statement
October 16-18, 1995
This statement is published as:
Integration of
Behavioral and Relaxation Approaches into the Treatment of
Chronic Pain and Insomnia. NIH Technol Assess Statement 1995 Oct
16-18:1-34
For making bibliographic reference to technology assessment
conference statement no. 17 in electronic form displayed here, it
is recommended that the following format be used: Integration of
Behavioral and Relaxation Approaches into the Treatment of
Chronic Pain and Insomnia. NIH Technol Statement Online 1995 Oct
16-18 [cited year month day], 1-34.
Abstract
Introduction
What Behavioral and Relaxation Approaches Are Used for Conditions Such as Chronic Pain and Insomnia?
How Successful Are These Approaches?
How Do These Approaches Work?
Are There Barriers To the Appropriate Integration of These Approaches Into Health Care?
What Are the Significant Issues for Future Research and Applications?
Technology Assessment Panel
Speakers
Planning Committee
Conference Sponsors
Conference Cosponsors
Bibliography
About the NIH Consensus Development Program
Statement Availability
Abstract
Objective. To provide physicians with a responsible
assessment of the integration of behavioral and relaxation
approaches into the treatment of chronic pain and insomnia.
Participants. A non-Federal, nonadvocate, 12-member panel
representing the fields of family medicine, social medicine,
psychiatry, psychology, public health, nursing, and epidemiology.
In addition, 23 experts in behavioral medicine, pain medicine,
sleep medicine, psychiatry, nursing, psychology, neurology, and
behavioral and neurosciences presented data to the panel and a
conference audience of 528.
Evidence. The literature was searched through Medline and
an extensive bibliography of references was provided to the panel
and the conference audience. Experts prepared abstracts with
relevant citations from the literature. Scientific evidence was
given precedence over clinical anecdotal experience.
Assessment Process. The panel, answering predefined
questions, developed their conclusions based on the scientific
evidence presented in open forum and the scientific literature.
The panel composed a draft statement that was read in its
entirety and circulated to the experts and the audience for
comment. Thereafter, the panel resolved conflicting
recommendations and released a revised statement at the end of
the conference. The panel finalized the revisions within a few
weeks after the conference.
Conclusions. A number of well-defined behavioral and
relaxation interventions now exist and are effective in the
treatment of chronic pain and insomnia. The panel found strong
evidence for the use of relaxation techniques in reducing chronic
pain in a variety of medical conditions as well as strong
evidence for the use of hypnosis in alleviating pain associated
with cancer. The evidence was moderate for the effectiveness of
cognitive-behavioral techniques and biofeedback in relieving
chronic pain. Regarding insomnia, behavioral techniques,
particularly relaxation and biofeedback, produce improvements in
some aspects of sleep, but it is questionable whether the
magnitude of the improvement in sleep onset and total sleep time
is clinically significant.
Introduction
Chronic pain and insomnia afflict millions of Americans.
Despite the acknowledged importance of psychosocial and
behavioral factors in these disorders, treatment strategies have
tended to focus on biomedical interventions such as drugs and
surgery. The purpose of this conference was to examine the
usefulness of integrating behavioral and relaxation approaches
with biomedical interventions in clinical and research settings
to improve the care of patients with chronic pain and
insomnia.
Assessments of more consistent and effective integration of
these approaches required the development of precise definitions
of the most frequently used techniques, which include relaxation,
meditation, hypnosis, biofeedback (BF), and cognitive-behavioral
therapy (CBT). It was also necessary to examine how these
approaches have been previously used with medical therapies in
the treatment of chronic pain and insomnia and to evaluate the
efficacy of such integration to date.
To address these issues, the Office of Alternative Medicine
and the Office of Medical Applications of Research, National
Institutes of Health, convened a Technology Assessment Conference
on Integration of Behavioral and Relaxation Approaches into the
Treatment of Chronic Pain and Insomnia. The conference was
cosponsored by the National Institute of Mental Health, the
National Institute of Dental Research, the National Heart, Lung,
and Blood Institute, the National Institute on Aging, the
National Cancer Institute, the National Institute of Nursing
Research, the National Institute of Neurological Disorders and
Stroke, and the National Institute of Arthritis and
Musculoskeletal and Skin Diseases.
This technology assessment conference (1) reviewed data on the
relative merits of specific behavioral and relaxation
interventions and identified biophysical and psychological
factors that might predict the outcome of applying these
techniques and (2) examined the mechanisms by which behavioral
and relaxation approaches could lead to greater clinical
efficacy.
The conference brought together experts in behavioral
medicine, pain medicine, sleep medicine, psychiatry, nursing,
psychology, neurology, behavioral science, and neuroscience as
well as representatives from the public. After 1-1/2 days of
presentations and audience discussion, an independent, non-
Federal panel weighed the scientific evidence and developed a
draft statement that addressed the following five questions:
- What behavioral and relaxation approaches are used for
conditions such as chronic pain and insomnia?
- How successful are these approaches?
- How do these approaches work?
- Are there barriers to the appropriate integration of these
approaches into health care?
- What are the significant issues for future research and
applications?
The suffering and disability from these disorders result in a
heavy burden for individual patients, their families, and their
communities. There is also a burden to the Nation in terms of
billions of dollars lost as a consequence of functional
impairment. To date, conventional medical and surgical
approaches have failed&emdash;at considerable expense&emdash;to
adequately address these problems. It is hoped that this
Consensus Statement, which is based on rigorous examination of
current knowledge and practice and makes recommendations for
research and application, will help reduce suffering and improve
the functional capacity of affected individuals.
What Behavioral and Relaxation Approaches Are Used for Conditions Such as Chronic Pain and Insomnia?
Pain
Pain is defined by the International Association for the Study
of Pain as an unpleasant sensory experience associated with
actual or potential tissue damage or described in terms of such
damage. It is a complex, subjective, perceptual phenomenon with
a number of contributing factors that are uniquely experienced by
each individual. Pain is typically classified as acute, cancer-
related, and chronic nonmalignant. Acute pain is associated with
a noxious event. Its severity is generally proportional to the
degree of tissue injury and is expected to diminish with healing
and time. Chronic nonmalignant pain frequently develops
following an injury but persists long after a reasonable period
of healing. Its underlying causes are often not readily
discernible, and the pain is disproportionate to demonstrable
tissue damage. It is frequently accompanied by alteration of
sleep; mood; and sexual, vocational, and avocational
function.
Insomnia
Insomnia may be defined as a disturbance or perceived
disturbance of the usual sleep pattern of the individual that has
troublesome consequences. These consequences may include daytime
fatigue and drowsiness, irritability, anxiety, depression, and
somatic complaints. Categories of disturbed sleep are (1)
inability to fall asleep, (2) inability to maintain sleep, and
(3) early awakening.
Selection Criteria
A variety of behavioral and relaxation approaches are used for
conditions such as chronic pain and insomnia. The specific
approaches that were addressed in this Technology Assessment
Conference were selected using three important criteria. First,
somatically directed therapies with behavioral components (e.g.,
physical therapy, occupational therapy, acupuncture) were not
considered. Second, the approaches were drawn from those
reported in the scientific literature. Many commonly used
behavioral approaches are not specifically incorporated into
conventional medical care. For example, religious and spiritual
approaches, which are the most commonly used health-related
actions by the U.S. population, were not considered in this
conference. Third, the approaches are a subset of those
discussed in the literature and represent those selected by the
conference organizers as most commonly used in clinical settings
in the United States. Several commonly used clinical
interventions such as music, dance, recreational, and art
therapies were not addressed.
Relaxation Techniques
Relaxation techniques are a group of behavioral therapeutic
approaches that differ widely in their philosophical bases as
well as in their methodologies and techniques. Their primary
objective is the achievement of nondirected relaxation, rather
than direct achievement of a specific therapeutic goal. They all
share two basic components: (1) repetitive focus on a word,
sound, prayer, phrase, body sensation, or muscular activity and
(2) the adoption of a passive attitude toward intruding thoughts
and a return to the focus. These techniques induce a common set
of physiologic changes that result in decreased metabolic
activity. Relaxation techniques may also be used in stress
management (as self-regulatory techniques) and have been divided
into deep and brief methods.
Deep Methods
Deep methods include autogenic training, meditation, and
progressive muscle relaxation (PMR). Autogenic training consists
of imagining a peaceful environment and comforting bodily
sensations. Six basic focusing techniques are used: heaviness
in the limbs, warmth in the limbs, cardiac regulation, centering
on breathing, warmth in the upper abdomen, and coolness in the
forehead. Meditation is a self-directed practice for relaxing
the body and calming the mind. A large variety of meditation
techniques are in common use; each has its own proponents.
Meditation generally does not involve suggestion, autosuggestion,
or trance. The goal of mindfulness meditation is development of
a nonjudgmental awareness of bodily sensations and mental
activities occurring in the present moment. Concentration
meditation trains the person to passively attend to a bodily
process, a word, and/or a stimulus. Transcendental meditation
focuses on a "suitable" sound or thought (the mantra) without
attempting to actually concentrate on the sound or thought.
There are also many movement meditations, such as yoga and the
walking meditation of Zen Buddhism. PMR focuses on reducing
muscle tone in major muscle groups. Each of 15 major muscle
groups is tensed and then relaxed in sequence.
Brief Methods
The brief methods, which include self-control relaxation,
paced respiration, and deep breathing, generally require less
time to acquire or practice and often represent abbreviated forms
of a corresponding deep method. For example, self-control
relaxation is an abbreviated form of PMR. Autogenic training may
be abbreviated and converted to a self-control format. Paced
respiration teaches patients to maintain slow breathing when
anxiety threatens. Deep breathing involves taking several deep
breaths, holding them for 5 seconds, and then exhaling
slowly.
Hypnotic Techniques
Hypnotic techniques induce states of selective attentional
focusing or diffusion combined with enhanced imagery. They are
often used to induce relaxation and also may be a part of CBT.
The techniques have pre- and postsuggestion components. The
presuggestion component involves attentional focusing through the
use of imagery, distraction, or relaxation, and has features that
are similar to other relaxation techniques. Subjects focus on
relaxation and passively disregard intrusive thoughts. The
suggestion phase is characterized by introduction of specific
goals; for example, analgesia may be specifically suggested. The
postsuggestion component involves
continued use of the new behavior following termination of
hypnosis. Individuals vary widely in their hypnotic
susceptibility and suggestibility, although the reasons for these
differences are incompletely understood.
Biofeedback Techniques
BF techniques are treatment methods that use monitoring
instruments of various degrees of sophistication. BF techniques
provide patients with physiologic information that allows them to
reliably influence psychophysiological responses of two kinds:
(1) responses not ordinarily under voluntary control and (2)
responses that ordinarily are easily regulated, but for which
regulation has broken down. Technologies that are commonly used
include electromyography (EMG BF), electroencephalography,
thermometers (thermal BF), and galvanometry (electrodermal-BF).
BF techniques often induce physiological responses similar to
those of other relaxation techniques.
Cognitive-Behavioral Therapy
CBT attempts to alter patterns of negative thoughts and
dysfunctional attitudes in order to foster more healthy and
adaptive thoughts, emotions, and actions. These interventions
share four basic components: education, skills acquisition,
cognitive and behavioral rehearsal, and generalization and
maintenance. Relaxation techniques are frequently included as a
behavioral component in CBT programs. The specific programs used
to implement the four components can vary considerably. Each of
the aforementioned therapeutic modalities may be practiced
individually, or they may be combined as part of multimodal
approaches to manage chronic pain or insomnia.
Relaxation and Behavioral Techniques for Insomnia
Relaxation and behavioral techniques corresponding to those
used for chronic pain may also be used for specific types of
insomnia. Cognitive relaxation, various forms of BF, and PMR may
all be used to treat insomnia. In addition, the following
behavioral approaches are generally used to manage insomnia:
- Sleep hygiene, which involves educating patients about
behaviors that may interfere with the sleep process, with the
hope that education about maladaptive behaviors will lead to
behavioral modification.
- Stimulus control therapy, which seeks to create and protect
conditioned association between the bedroom and sleep.
Activities in the bedroom are restricted to sleep and sex.
- Sleep restriction therapy, in which patients provide a sleep
log and are then asked to stay in bed only as long as they think
they are currently sleeping. This usually leads to sleep
deprivation and consolidation, which may be followed by a gradual
increase in the length of time in bed.
- Paradoxical intention, in which the patient is instructed not
to fall asleep, with the expectation that efforts to avoid sleep
will in fact induce it.
How Successful Are These Approaches?
Pain
A plethora of studies using a range of behavioral and
relaxation approaches to treat chronic pain is reported in the
literature. The measures of success reported in these studies
depend on the rigor of the research design, the population
studied, the length of followup, and the outcome measures
identified. As the number of well-designed studies using a
variety of behavioral and relaxation techniques grows, the use of
meta-analysis as a means of demonstrating overall effectiveness
will increase.
One carefully analyzed review of studies on chronic pain,
including cancer pain, was prepared under the auspices of the
U.S. Agency for Health Care Policy and Research (AHCPR) in 1990.
A great strength of the report was the careful categorization of
the evidential basis of each intervention. The categorization
was based on design of the studies and consistency of findings
among the studies. These properties led to the development of a
4-point scale that ranked the evidence as strong, moderate, fair,
or weak; this scale was used by the panel to evaluate the AHCPR
studies.
Evaluation of behavioral and relaxation interventions for
chronic pain reduction in adults found the following:
- Relaxation: The evidence is strong for the effectiveness of
this class of techniques in reducing chronic pain in a variety of
medical conditions.
- Hypnosis: The evidence supporting the effectiveness of
hypnosis in alleviating chronic pain associated with cancer seems
strong. In addition, the panel was presented with other data
suggesting the effectiveness of hypnosis in other chronic pain
conditions, which include irritable bowel syndrome, oral
mucositis, temporomandibular disorders, and tension
headaches.
- CBT: The evidence was moderate for the usefulness of CBT in
chronic pain. In addition, a series of eight well-designed
studies found CBT superior to placebo and to routine care for
alleviating low back pain and both rheumatoid arthritis and
osteoarthritis-associated pain, but inferior to hypnosis for oral
mucositis and to EMG BF for tension headache.
- BF: The evidence is moderate for the effectiveness of BF in
relieving many types of chronic pain. Data were also reviewed
showing EMG BF to be more effective than psychological placebo
for tension headache but equivalent in results to relaxation.
For migraine headache, BF is better than relaxation therapy and
better than no treatment, but superiority to psychological
placebo is less clear.
- Multimodal Treatment: Several meta-analyses examined the
effectiveness of multimodal treatments in clinical settings. The
results of these studies indicate a consistent positive effect of
these programs on several categories of regional pain. Back and
neck pain, dental or facial pain, joint pain, and migraine
headaches have all been treated effectively.
Although relatively good evidence exists for the efficacy of
several behavioral and relaxation interventions in the treatment
of chronic pain, the data are insufficient to conclude that one
technique is usually more effective than another for a given
condition. For any given individual patient, however, one
approach may indeed be more appropriate than another.
Insomnia
Behavioral treatments produce improvements in some aspects of
sleep, the most pronounced of which are for sleep latency and
time awake after sleep onset. Relaxation and BF were both found
to be effective in alleviating insomnia. Cognitive forms of
relaxation such as meditation were slightly better than somatic
forms of relaxation such as PMR. Sleep restriction, stimulus
control, and multimodal treatment were the three most effective
treatments in reducing insomnia. No data were presented or
reviewed on the effectiveness of CBT or hypnosis. Improvements
seen at treatment completion were maintained at followups
averaging 6 months in duration. Although these effects are
statistically significant, it is questionable whether the
magnitude of the improvements in sleep onset and total sleep time
are clinically meaningful. It is possible that a patient-by-
patient analysis might show that the effects were clinically
valuable for a special set of patients, as some studies suggest
that patients who are readily hypnotized benefited much more from
certain treatments than other patients did. No data were
available on the effects of these improvements on patient self-
assessment of quality of life.
To adequately evaluate the relative success of different
treatment modalities for insomnia, two major issues need to be
addressed. First, valid objective measures of insomnia are
needed. Some investigators rely on self-reports by patients,
whereas others believe that insomnia must be documented
electrophysiologically. Second, what constitutes a therapeutic
outcome should be determined. Some investigators use time until
sleep onset, number of awakenings, and total sleep time as
outcome measures, whereas others believe that impairment in
daytime functioning is perhaps another important outcome measure.
Both of these issues require resolution so that research in the
field can move forward.
Critique
Several cautions must be considered threats to the internal
and external validity of the study results. The following
problems pertain to internal validity: (1) full and adequate
comparability among treatment contrast groups may be absent; (2)
the sample sizes are sometimes small, lessening the ability to
detect differences in efficacy; (3) complete blinding, which
would be ideal, is compromised by patient and clinician awareness
of the treatment; (4) the treatments may not be well described,
and adequate procedures for standardization such as therapy
manuals, therapist training, and reliable competency and
integrity assessments have not always been carried out; and (5) a
potential publication bias, in which authors exclude studies with
small effects and negative results, is of concern in a field
characterized by studies with small numbers of patients.
With regard to the ability to generalize the findings of these
investigations, the following considerations are important:
- The patients participating in these studies are usually not
cognitively impaired. They must be capable not only of
participating in the study treatments but also of fulfilling all
the requirements of participating in the study protocol.
- The therapists must be adequately trained to competently
conduct the therapy.
- The cultural context in which the treatment is conducted may
alter its acceptability and effectiveness.
In summary, this literature offers substantial promise and
suggests a need for prompt translation into programs of health
care delivery. At the same time, the state of the art of the
methodology in the field of behavioral and relaxation
interventions indicates a need for thoughtful interpretation of
these findings. It should be noted that similar criticisms can
be made of many conventional medical procedures.
How Do These Approaches Work?
The mechanism of action of behavioral and relaxation
approaches can be considered at two levels: (1) determining how
the procedure works to reduce cognitive and physiological arousal
and to promote the most appropriate behavioral response and (2)
identifying effects at more basic levels of functional anatomy,
neurotransmitter and other biochemical activity, and circadian
rhythms. The exact biological actions are generally unknown.
Pain
There appear to be two pain transmission circuits. Some data
suggest that a spinal cord-thalamic-frontal cortex-anterior
cingulate pathway plays a role in the subjective psychological
and physiological responses to pain, whereas a spinal cord-
thalamic-somatosensory cortex pathway plays a role in pain
sensation. A descending pathway involving the periaqueductal
gray region modulates pain signals (pain modulation circuit).
This system can augment or inhibit pain transmission at the level
of the dorsal spinal cord. Endogenous opioids are particularly
concentrated in this pathway. At the level of the spinal cord,
serotonin and norepinephrine appear to play important roles.
Relaxation techniques as a group generally alter sympathetic
activity as indicated by decreases in oxygen consumption,
respiratory and heart rate, and blood pressure. Increased
electroencephalographic slow wave activity has also been
reported. Although the mechanism for the decrease in sympathetic
activity is unclear, one may infer that decreased arousal (due to
alterations in catecholamines or other neurochemical systems)
plays a key role.
Hypnosis, in part because of its capacity for evoking intense
relaxation, has been reported to reduce several types of pain
(e.g., lower back and burn pain). Hypnosis does not appear to
influence endorphin production, and its role in the production of
catecholamines is not known.
Hypnosis has been hypothesized to block pain from entering
consciousness by activating the frontal-limbic attention system
to inhibit pain impulse transmission from thalamic to cortical
structures. Similarly, other CBT may decrease transmission
through this pathway. Moreover, the overlap in brain regions
involved in pain modulation and anxiety suggests a possible role
for CBT approaches affecting this area of function, although data
are still evolving.
CBT also appears to exert a number of other effects that could
alter pain intensity. Depression and anxiety increase subjective
complaints of pain, and cognitive-behavioral approaches are well
documented for decreasing these affective states. In addition,
these types of techniques may alter expectation, which also plays
a key role in subjective experiences of pain intensity. They
also may augment analgesic responses through behavioral
conditioning. Finally, these techniques help patients enhance
their sense of self control over their illness enabling them to
be less helpless and better able to deal with pain
sensations.
Insomnia
A cognitive-behavioral model for insomnia (see Figure 1)
elucidates the interaction of insomnia with emotional,
cognitive, and physiologic arousal; dysfunctional conditions,
such as worry over sleep; maladaptive habits (e.g., excessive
time in bed and daytime napping); and the consequences of
insomnia (e.g., fatigue and impairment in performance of
activities).
In the treatment of insomnia, relaxation techniques have been
used to reduce cognitive and physiological arousal and thus
assist the induction of sleep as well as decrease awakenings
during sleep.
Relaxation is also likely to influence decreased activity in
the entire sympathetic system, permitting a more rapid and
effective "deafferentation" at sleep onset at the level of the
thalamus. Relaxation may also enhance parasympathetic activity,
which in turn will further decrease autonomic tone. In addition,
it has been suggested that alterations in cytokine activity
(immune system) may play a role in insomnia or in response to
treatment.
Cognitive approaches may decrease arousal and dysfunctional
beliefs and thus improve sleep. Behavioral techniques including
sleep restriction and stimulus control can be helpful in reducing
physiologic arousal, reversing poor sleep habits, and shifting
circadian rhythms. These effects appear to involve both cortical
structures and deep nuclei (e.g., locus ceruleus and
suprachiasmatic nucleus).
Knowing the mechanisms of action would reinforce and expand
use of behavioral and relaxation techniques, but incorporation of
these approaches into the treatment of chronic pain and insomnia
can proceed on the basis of clinical efficacy, as has occurred
with adoption of other practices and products before their mode
of action was completely delineated.
Are There Barriers To the Appropriate Integration of These Approaches Into Health Care?
One barrier to the integration of behavioral and relaxation
techniques in standard medical care has been the emphasis solely
on the biomedical model as the basis of medical education. The
biomedical model defines disease in anatomic and pathophysiologic
terms. Expansion to a biopsychosocial model would increase
emphasis on a patient's experience of disease and balance the
anatomic/physiologic needs of patients with their psychosocial
needs.
For example, of six factors identified to correlate with
treatment failures of low back pain, all are psychosocial.
Integration of behavioral and relaxation therapies with
conventional medical procedures is necessary for the successful
treatment of such conditions. Similarly, the importance of a
comprehensive evaluation of a patient is emphasized in the field
of insomnia where failure to identify a condition such as sleep
apnea will result in inappropriate application of a behavioral
therapy. Therapy should be matched to the illness and to the
patient.
Integration of psychosocial issues with conventional medical
approaches will necessitate the application of new methodologies
to assess the success or failure of the interventions.
Therefore, additional barriers to integration include lack of
standardization of outcome measures, lack of standardization or
agreement on what constitutes successful outcome, and lack of
consensus on what constitutes appropriate followup.
Methodologies appropriate for the evaluation of drugs may not be
adequate for the evaluation of some psychosocial interventions,
especially those involving patient experience and quality of
life. Psychosocial research studies must maintain the high
quality of those methods that have been painstakingly developed
over the last few decades. Agreement needs to be reached for
standards governing the demonstration of efficacy for
psychosocial interventions.
Psychosocial interventions are often time intensive, creating
potential blocks to provider and patient acceptance and
compliance. Participation in BF training typically includes up
to 10-12 sessions of approximately 45 minutes to 1 hour each. In
addition, home practice of these techniques is usually required.
Thus, patient compliance and both patient and provider
willingness to participate in these therapies will have to be
addressed. Physicians will have to be educated on the efficacy
of these techniques. They must also be willing to educate their
patients about the importance and potential benefits of these
interventions and to provide encouragement for the patient
through the training processes.
Insurance companies provide either a financial incentive or
barrier to access of care depending on their willingness to
provide reimbursement. Insurance companies have traditionally
been reluctant to reimburse for some psychosocial interventions
and reimburse others at rates below those for standard medical
care. Psychosocial interventions for pain and insomnia should be
reimbursed as part of comprehensive medical services at rates
comparable to those for other medical care, particularly in view
of data supporting their effectiveness and data detailing the
costs of failed medical and surgical interventions.
The evidence suggests that sleep disorders are significantly
underdiagnosed. The prevalence and possible consequences of
insomnia have begun to be documented. There are substantial
disparities between patient reports of insomnia and the number of
insomnia diagnoses, as well as between the number of
prescriptions written for sleep medications and the number of
recorded diagnoses of insomnia. Data indicate that insomnia is
widespread, but the morbidity and mortality of this condition are
not well understood. Without this information, it remains
difficult for physicians to gauge how aggressive their
intervention should be in the treatment of this disorder. In
addition, the efficacy of the behavioral approaches for treating
this condition has not been adequately disseminated to the
medical community.
Finally, who should be administering these therapies?
Problems with credentialing and training have yet to be
completely addressed in the field. Although the initial studies
have been done by qualified and highly trained practitioners, the
question remains as to how this will best translate into delivery
of care in the community. Decisions will have to be made about
which practitioners are best qualified and most cost-effective to
provide these psychosocial interventions.
What Are the Significant Issues for Future Research and Applications?
Research efforts on these therapies should include additional
efficacy and effectiveness studies, cost-effectiveness studies,
and efforts to replicate existing studies. Several specific
issues should be addressed:
Outcomes
- Outcome measures should be reliable, valid, and standardized
for behavioral and relaxation interventions research in each area
(chronic pain, insomnia) so that studies can be compared and
combined.
- Qualitative research is needed to help determine patients'
experiences with both insomnia and chronic pain and the impact of
treatments.
- Future research should include examination of
consequences/outcomes of untreated chronic pain and insomnia;
chronic pain and insomnia treated pharmacologically versus with
behavioral and relaxation therapies; and combinations of
pharmacologic and psychosocial treatments for chronic pain and
insomnia.
Mechanism(s) of Action
- Advances in the neurobiological sciences and
psychoneuroimmunology are providing an improved scientific base
for understanding mechanisms of action of behavioral and
relaxation techniques and need to be further investigated.
Covariates
- Chronic pain and insomnia, as well as behavioral and
relaxation therapies, involve factors such as values, beliefs,
expectations, and behaviors, all of which are strongly shaped by
one's culture. Research is needed to assess cross-cultural
applicability, efficacy, and modifications of psychosocial
therapeutic modalities.
- Research studies that examine the effectiveness of
behavioral and relaxation approaches to insomnia and chronic pain
should consider the influence of age, race, gender, religious
belief, and socioeconomic status on treatment effectiveness.
Health Services
- The most effective timing of the introduction of behavioral
interventions into the course of treatment should be
studied.
- Research is needed to optimize the match between specific
behavioral and relaxation techniques and specific patient groups
and treatment settings.
Integration Into Clinical Care and Medical Education
- New and innovative methods of introducing psychosocial
treatments into health care curricula and practice should be
implemented.
Conclusions
A number of well-defined behavioral and relaxation
interventions are now available, some of which are commonly used
to treat chronic pain and insomnia. Available data support the
effectiveness of these interventions in relieving chronic pain
and in achieving some reduction in insomnia. Data are currently
insufficient to conclude with confidence that one technique is
more effective than another for a given condition. For any given
individual patient, however, one approach may indeed be more
appropriate than another.
Behavioral and relaxation interventions clearly reduce
arousal, and hypnosis reduces pain perception. However, the
exact biological underpinnings of these effects require further
study, as is often the case with medical therapies. The
literature demonstrates treatment effectiveness, although the
state of the art of the methodologies in this field indicates a
need for thoughtful interpretation of the findings along with
prompt translation into programs of health care delivery.
Although specific structural, bureaucratic, financial, and
attitudinal barriers exist to the integration of these
techniques, all are potentially surmountable with education and
additional research, as patients shift from being passive
participants in their treatment to becoming responsible, active
partners in their rehabilitation.
Technology Assessment Panel
Julius Richmond, M.D.
Conference and Panel Chairperson
The John D. MacArthur Professor of Health Policy
Emeritus
Department of Social Medicine
Harvard Medical School
Boston, Massachusetts
Brian M. Berman, M.D.
Director
Division of Complementary Medicine
Department of Family Medicine
University of Maryland School of Medicine
Baltimore, Maryland
John P. Docherty, M.D.
Vice Chairman
Department of Psychiatry
Cornell University Medical College
Associate Medical Director
New York Hospital/Cornell University
White Plains, New York
Larry B. Goldstein, M.D.
Associate Professor of Medicine
Division of Neurology
Department of Medicine
Assistant Research Professor
Center for Health Policy Research and Education
Duke University Medical Center
Durham VA Medical Center
Durham, North Carolina
Gary Kaplan, D.O.
Clinical Faculty
Department of Family and Community Medicine
Georgetown University School of Medicine
Family Practice Associates of Arlington
Arlington, Virginia
Julian E. Keil, Dr.P.H., F.A.C.C.
Professor of Epidemiology, Emeritus
Department of Biostatistics, Epidemiology, and Systems
Science
Medical University of South Carolina
Charleston, South Carolina
Stanley Krippner, Ph.D.
Professor of Psychology
Saybrook Institute Graduate School and Research Center
San Francisco, California
Sheila Lyne, R.S.M., M.B.A., M.S.
Commissioner
Chicago Department of Public Health
DePaul Center
Chicago, Illinois
Frederick Mosteller, Ph.D.
Professor of Mathematical Statistics, Emeritus
Departments of Statistics and Health Policy and
Management
Harvard University
Cambridge, Massachusetts
Bonnie B. O'Connor, Ph.D.
Assistant Professor
Department of Community and Preventive Medicine
Medical College of Pennsylvania and
Hahnemann University School of Medicine
Philadelphia, Pennsylvania
Ellen B. Rudy, Ph.D., R.N., F.A.A.N.
Dean
School of Nursing
University of Pittsburgh
Pittsburgh, Pennsylvania
Alan F. Schatzberg, M.D.
Professor and Chairman
Department of Psychiatry
Stanford University School of Medicine
Stanford, California
Speakers
Herbert Benson, M.D.
"The Common Physiological Events That Occur When Behavioral and
Relaxation Approaches Are Practiced by Patients"
Chief, Division of Behavioral Medicine
Deaconess Hospital
Associate Professor of Medicine
Mind/Body Medical Institute
Boston, Massachusetts
Edward B. Blanchard, Ph.D.
"Biofeedback and its Role in the Treatment of Pain"
Distinguished Professor of Psychology
Center for Stress and Anxiety Disorders
Department of Psychology
University of Albany
State University of New York
Albany, New York
Laurence A. Bradley, Ph.D.
"Cognitive Intervention Strategies for Chronic Pain:
Assumptions Underlying Cognitive Therapy"
Professor of Medicine
Department of Medicine
Division of Clinical Immunology and Rheumatology
University of Alabama at Birmingham School of Medicine
Birmingham, Alabama
Daniel J. Buysse, M.D.
"Potential Mechanisms of Action of Behavioral and
Relaxation Treatments in Insomnia"
Associate Professor of Psychiatry
Department of Psychiatry
Western Psychiatric Institute and Clinic
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania
Helen J. Crawford, Ph.D.
"Use of Hypnotic Techniques in the Control of Pain:
Neuropsychophysiological Foundation and Evidence"
Department of Psychology
College of Arts and Sciences
Virginia Polytechnic Institute and State University
Blacksburg, Virginia
William C. Dement, M.D., Ph.D.
"The Insomnia Problem: Definitions and Scope"
Lowell W. and Josephine Q. Berry Professor of Psychiatry
and Sleep Medicine
Department of Psychiatry and Behavioral Sciences
Director, Sleep Research Center
Stanford University School of Medicine
Palo Alto, California
Howard L. Fields, M.D., Ph.D.
"Brain Systems for Pain Modulation: Understanding the Neurobiology
of the Therapeutic Process"
Professor of Neurology and Physiology
Department of Neurology
School of Medicine
University of California, San Francisco
San Francisco, California
David A. Fishbain, M.Sc., M.D., F.A.P.A.
"Chronic Pain Treatment Meta-Analyses: A Mathematical and Qualitative
Review and Patient-Specific Predictors of Response"
Professor of Psychiatry and Neurological Surgery
University of Miami School of Medicine and
the University of Miami Comprehensive Pain Center
Miami Beach, Florida
Richard Friedman, Ph.D.
"Conference Background"
Professor of Psychiatry and Behavioral Science
Department of Psychiatry
State University of New York at Stony Brook
Stony Brook, New York
Rollin M. Gallagher, M.D.
"The Comprehensive Pain Clinic: A Biobehavioral Approach to Pain
Management and Rehabilitation"
Associate Professor of Psychiatry and Family Medicine
Director
The Comprehensive Pain and Rehabilitation Center
State University of New York at Stony Brook
Stony Brook, New York
J. David Haddox, D.D.S., M.D.
"Overview of Pain"
Assistant Professor
Anesthesiology and Psychiatry
Emory University School of Medicine
Atlanta, Georgia
Kristyna M. Hartse, Ph.D.
"Intervention and Patient-Specific Response Rates"
Director
Sleep Disorders Center
Associate Professor
Department of Psychiatry and Human Behavior
St. Louis University Health Sciences Center School of Medicine
St. Louis, Missouri
Peter J. Hauri, Ph.D.
"Behavioral Treatment of Insomnia"
Professor of Psychology
Mayo Medical School
Director, Insomnia Program
Department of Psychology
Sleep Disorders Center
The Mayo Clinic
Rochester, Minnesota
Eileen C. Helzner, M.D.
"Clinical Integration With Pharmacologic Treatments"
Director, Clinical Development
McNeil Consumer Products Company
Johnson & Johnson
Ft. Washington, Pennsylvania
Ada Jacox, R.N., Ph.D.
"Outcomes Research on Integration: Lessons From Cancer and Acute Pain"
Professor and Independence Foundation
Chair in Health Policy
School of Nursing
Johns Hopkins University
Baltimore, Maryland
Jeffrey M. Jonas, M.D.
"Clinical Integration With Pharmacologic Treatments"
Vice President of Clinical Development
The Upjohn Company
Kalamazoo, Michigan
Francis J. Keefe, Ph.D.
"Intervention-Specific Response Rates"
Professor of Medical Psychology
Pain Management Program
Department of Psychiatry and Behavioral Sciences
Duke University Medical Center
Durham, North Carolina
Kenneth L. Lichstein, Ph.D.
"Defining Relaxation Approaches as They Relate to Biomedicine"
Professor of Psychology
Department of Psychology
The University of Memphis
Memphis, Tennessee
John D. Loeser, M.D.
"Integration of Behavioral and Relaxation Approaches With Surgery in the
Treatment of Chronic Pain: A Clinical Perspective"
Professor of Neurological Surgery and Anesthesia
Director, Multidisciplinary Pain Center
University of Washington School of Medicine
Seattle, Washington
Wallace B. Mendelson, M.D.
"Integrating Pharmacologic and Nonpharmacologic Treatment of Insomnia"
Director
Sleep Disorders Center
Section of Epilepsy and Sleep Disorders
Department of Neurology
The Cleveland Clinic Foundation
Professor of Psychiatry
Ohio State University
Cleveland, Ohio
David Orme-Johnson, Ph.D.
"Meditation in the Treatment of Chronic Pain and Insomnia"
Director of Research
Chair, Department of Psychology
Maharishi International University
Fairfield, Iowa
Thomas Roth, Ph.D.
"Assessment and Methodological Problems in the Evaluation of
Insomnia Treatment"
Chief
Division of Sleep Medicine
Director
Sleep Disorders and Research Center
Department of Psychiatry
Henry Ford Hospital
Detroit, Michigan
Dennis C. Turk, Ph.D.
"Assessing People Reporting Pain Not Just the Pain"
Professor of Psychiatry Anesthesiology, and Behavioral Science
Director
Pain Evaluation and Treatment Institute
University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania
Planning Committee
Richard Friedman, Ph.D.
Chairperson
Professor
Psychiatry and Behavioral Science
Department of Psychiatry
State University of New York at Stony Brook
Stony Brook, New York
Fred Altman, Ph.D.
Acting Chief
Basic Prevention and Behavioral Medicine Research Branch
Division of Epidemiology and Services Research
National Institute of Mental Health
National Institutes of Health
Bethesda, Maryland
Herbert Benson, M.D.
Chief
Division of Behavioral Medicine
Deaconess Hospital
Associate Professor of Medicine
Mind/Body Medical Institute
Boston, Massachusetts
Jerry M. Elliott
Program Analyst
Office of Medical Applications of Research
National Institutes of Health
Bethesda, Maryland
John H. Ferguson, M.D.
Director
Office of Medical Applications of Research
National Institutes of Health
Bethesda, Maryland
Richard Gracely, Ph.D.
Research Psychologist
Neuropathic and Pain Measurement Section
Neurobiology and Anesthesiology Branch
National Institute of Dental Research
National Institutes of Health
Bethesda, Maryland
Anita Greene, M.A.
Public Affairs Officer
Office of Alternative Medicine
National Institutes of Health
Bethesda, Maryland
J. David Haddox, D.D.S., M.D.
Assistant Professor
Anesthesiology and Psychiatry
Emory University School of Medicine
Atlanta, Georgia
William H. Hall
Director of Communications
Office of Medical Applications of Research
National Institutes of Health
Bethesda, Maryland
Peter J. Hauri, Ph.D.
Professor of Psychology
Mayo Medical School
Director
Insomnia Program
Department of Psychology
Sleep Disorders Center
The Mayo Clinic
Rochester, Minnesota
Peter G. Kaufmann, Ph.D.
Group Leader
Behavioral Medicine Scientific Research Group
National Heart, Lung, and Blood Institute
National Institutes of Health
Bethesda, Maryland
James P. Kiley, Ph.D.
Director
National Center on Sleep Disorders Research
National Heart, Lung, and Blood Institute
National Institutes of Health
Bethesda, Maryland
Mary D. Leveck, Ph.D., R.N.
Health Scientist Administrator
Division of Extramural Programs
National Institute of Nursing Research
National Institutes of Health
Bethesda, Maryland
Charlotte B. McCutchen, M.D.
Medical Officer
Epilepsy Branch
Division of Convulsive, Developmental, and Neuromuscular Disorders
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Bethesda, Maryland
Andrew A. Monjan, Ph.D., M.P.H.
Chief
Neurobiology of Aging Program
Neuroscience and Neuropsychology of Aging Program
National Institute on Aging
National Institutes of Health
Bethesda, Maryland
Stanley R. Pillemer, M.D.
Medical Officer
Office of Prevention, Epidemiology, and Clinical Applications
National Institute of Arthritis and Musculoskeletal and Skin Diseases
National Institutes of Health
Bethesda, Maryland
Julius Richmond, M.D.
Conference and Panel Chairperson
The John D. MacArthur Professor of Health Policy Emeritus
Department of Social Medicine
Harvard Medical School
Boston, Massachusetts
Charles Sherman, Ph.D.
Deputy Director
Office of Medical Applications of Research
National Institutes of Health
Bethesda, Maryland
John Spencer, Ph.D.
Program Analyst
Office of Alternative Medicine
National Institutes of Health
Bethesda, Maryland
Claudette G. Varricchio, D.S.N., R.N.
Program Director
Community Oncology and Rehabilitation Branch
Division of Cancer Prevention and Control
National Cancer Institute
National Institutes of Health
Bethesda, Maryland
Conference Sponsors
Office of Medical Applications of Research, NIH
John H. Ferguson, M.D.
Director
Office of Alternative Medicine, NIH
Wayne B. Jonas, M.D.
Director
Conference Cosponsors
National Institute of Mental Health
Rex W. Cowdry, M.D.
Acting Director
National Institute of Dental Research
Harold C. Smavkin, D.D.S.
Director
National Heart, Lung, and Blood Institute
Claude Lenfant, M.D.
Director
National Institute on Aging
Richard J. Hodes, M.D.
Director
National Cancer Institute
Richard Klausner, M.D.
Director
National Institute of Nursing Research
Patricia A. Grady, R.N., Ph.D.
Director
National Institute of Neurological Disorders and Stroke
Zach W. Hall, Ph.D.
Director
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Stephen I. Katz, M.D., Ph.D.
Director
Bibliography
The following references were provided by the speakers listed
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