Introduction
NCI Materials
NCI Press Materials
NCI Cancer Information Service Fact Sheets
Other Materials
Current Clinical Trials
Introduction
SELECT (the Selenium and Vitamin E Cancer Prevention Trial) is the largest-ever prostate cancer prevention trial. Previous studies suggest that selenium and vitamin E (alone or in combination) may reduce the risk of developing prostate cancer by 60 percent and 30 percent, respectively, but only a large clinical trial such as SELECT can confirm those initial findings.
SELECT began enrolling patients on August 22, 2001, and closed enrollment on June 24, 2004, with 35,534 participants. About 15 percent of the participants are African-American.
The study includes men 55 and older. African-American men, 50 and over, were eligible to enroll because prostate cancer strikes African-American men earlier and more often than white men. There are 435 SELECT sites throughout the United States, Puerto Rico, and Canada.
Coordinated by a network of researchers called the Southwest Oncology Group (SWOG), the study is sponsored by the National Cancer Institute (NCI).
SWOG maintains a Web page with information about SELECT 2, including a list of participating sites.
To get more information about SELECT or to locate a participating center, call 1-800-4-CANCER in the United States and Puerto Rico or 1-888-939-3333 in Canada.
NCI Materials
SELECT Data: Enrollment Statistics 3
(Updated: 09/04/2003) - Enrollment data from SELECT, the Selenium and Vitamin E Cancer Prevention Trial.
Prostate Cancer (PDQ®): Prevention
[ patient ] 4 [ health professional ] 5
Expert-reviewed information summary about factors that may influence the risk of developing prostate cancer and about research aimed at the prevention of this disease.
Phase III Randomized Study of Selenium and Vitamin E for the Prevention of Prostate Cancer (SELECT Trial) 6
A summary of the SELECT protocol statement.
NCI Press Materials
Largest-Ever Prostate Cancer Prevention Trial Opens: 32,000 Men Sought to Test Vitamin E and Selenium 7
(Posted: 07/24/2001) - Healthy men age 55 and older are needed for the largest-ever prostate cancer prevention study, launched today by the NCI and a network of researchers known as the Southwest Oncology Group (SWOG).
Se inagura estudio de prevención de cáncer de próstata 8
(Posted: 07/24/2001) - Más de 400 centros en los Estados Unidos, Puerto Rico y Canadá están aceptando participantes para SELECT. Este estudio durará 12 años. SELECT es el primer estudio diseñado para observar directamente los efectos del selenio y la vitamina E, tanto juntos como por separado, para prevenir el cáncer de próstata.
Questions and Answers: SELECT (Selenium and Vitamin E Cancer Prevention Trial) 9
(Posted: 07/24/2001) - SELECT stands for the Selenium and Vitamin E Cancer Prevention Trial, which is a clinical trial to see if one or both of these dietary supplements prevent prostate cancer in men
Preguntas y respuestas: SELECT (Estudio del Selenio y la Vitamina E para Prevenir el Cancer) 10
(Posted: 07/24/2001, Updated: 04/29/2003) - SELECT, el Estudio del Selenio y la Vitamina E para Prevenir el Cáncer, es un estudio clínico para determinar si uno o ambos suplementos dietéticos previenen el cáncer de próstata.
Best Leads for Prostate Cancer Prevention Appear in April Urology Supplement; Agents, Biomarker Endpoints, Cohorts, and Trial Designs Outlined 11
(Posted: 04/09/2001) - The most promising agents to prevent prostate cancer and the most likely biological markers of risk for the disease are just two of the key areas of prostate cancer prevention research highlighted.
NCI Cancer Information Service Fact Sheets
Selenium and Vitamin E Cancer Prevention Trial (SELECT): Questions and Answers 12
A fact sheet that describes a clinical trial designed to determine if selenium and/or vitamin E can prevent prostate cancer.
Prostate Cancer Prevention Trial (PCPT): Questions and Answers 13
(Posted: 06/24/2003) - In the Prostate Cancer Prevention Trial (PCPT), 25 percent fewer men taking the drug finasteride developed prostate cancer than men not taking the drug. However, men who developed prostate cancer while taking finasteride were more likely to have high-grade cancers, which can spread quickly even if the tumors are small.
Other Materials
SELECT Home Page 14
Up-to-date information about the SELECT trial from SWOG, including contact information for men interested in participating.
Prevention and Early Detection Clinical Trials: Opportunities for Primary Care Providers and Their Patients
(Posted: 03/18/2003) - A paper published in the March/April 2003 issue of CA: A Cancer Journal for Clinicians examines some of the barriers to participation in prevention and early detection trials and provides information about various trials now open for enrollment.
Current Clinical Trials
Prevention of Prostate Cancer 15
List of open clinical trials investigating ways to prevent to prostate cancer, or to prevent a recurrence or progression of prostate cancer, from NCI's clinical trials database.
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