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# Title  Sort Principal Investigator  Sort State    Sort Institution  Sort Fund Mech,  Sort Project ID  Sort 1. Mechanism of Action of Folate Antagonists Bertino, Joseph R NJ Univ of Med/Dent NJ-R W Johnson MED Sch R01, CA008010 2. Centromere Structure and Function Carbon, John A CA University of California Santa Barbara R01, CA011034 3. Pharmacology of Cyclophosphamide and Other Alkylators Colvin, Oliver M NC Duke University R01, CA016783 4. Plant Antitumor Agents Lee, Kuo-Hsiung NC University of North Carolina Chapel Hill R01, CA017625 5. Cytotoxic Nitrogen Heterocycles Vedejs, Edwin MI University of Michigan at Ann Arbor R01, CA017918 6. Antiestrogens: Mechanism of Antagonist Action Katzenellenbogen, Benita S IL University of Illinois Urbana-Champaign R01, CA018119 7. Polynuclear Anticancer Antibiotics--Selected Syntheses Hauser, Frank NY State University of New York at Albany R01, CA018141 8. Applications of Natural Products to Chemical Biology Clardy, Jon C. MA Harvard University (Medical School) R01, CA024487 9. Rational Drug Design Based on Chemical Mechanisms Coward, James K MI University of Michigan at Ann Arbor R01, CA028097 10. Role of the Acetyltransferase P300 in Cellular Responses Avantaggiati, Maria L DC George Washington University R01, CA030716 11. Synthetic Studies on Tumor Promoters and Inhibitors Wender, Paul A CA Stanford University R01, CA031841 12. Synthetic Studies Related to Cancer Research/Treatment Wender, Paul A CA Stanford University R01, CA031845 13. Nucleoside and Nucleotide Metabolizing Enzymes Mitchell, Beverly S NC University of North Carolina Chapel Hill R01, CA034085 14. Natural Product Synthesis via Electron Deficient Imines Weinreb, Steven M. PA Pennsylvania State University-Univ Park R01, CA034303 15. Synthesis and Evaluation of Novel Phosphoramidates Borch, Richard F IN Purdue University West Lafayette R01, CA034619 16. Specificity of Intercalation Reactions Chaires, Jonathan B MS University of Mississippi Medical Center R01, CA035635 17. Therapeutic Modulation of Breast Cancer Oncogenes Benz, Christopher C CA Buck Institute for Age Research R01, CA036773 18. Role of Mitochondria and Glycolysis in Tumor Cell MDR Lampidis, Theodore J FL University of Miami-Medical R01, CA037109 19. Specific Immunotherapy with Monoclonal Antibodies Bast, Robert C TX University of Texas MD Anderson Can Ctr R01, CA039930 20. New Synthetic Methods for Anticancer Research Liebeskind, Lanny GA Emory University R01, CA040157 21. Genotoxicity of Antineoplastic DNA-Cleaving Agents Povirk, Lawrence VA Virginia Commonwealth University R01, CA040615 22. Crystallographic Studies of Thymidylate Synthase Finer-Moore, Janet S. CA University of California San Francisco R01, CA041323 23. The Antitumor Antibiotics CC-1065 and the Duocarmycins Boger, Dale L CA Scripps Research Institute R01, CA041986 24. Rheb, a Highly Conserved Farnesylated G-Protein Tamanoi, Fuyuhiko CA University of California Los Angeles R01, CA041996 25. Role of Polyamines in Estrogen Function in Breast Cancer Thomas, Thresia NJ Univ of Med/Dent NJ-R W Johnson MED Sch R01, CA042439

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