Co-Moderators:

Martin Abeloff, M.D., Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Carolyn Runowicz, M.D., University Hospital of Columbia University College of Physicians and Surgeons

February 24, 2003--Bethesda Marriott Pooks Hill

6:00-7:00 p.m.--Annapolis/Chesapeake Room

Briefing Session for Moderators, Group Leaders, Writers, and PowerPoint Technicians

7:00-9:00 p.m.--Congressional Ballroom

Introduction--Andrew von Eschenbach, M.D., Director, National Cancer Institute
Epidemiology Keynote--Robert Hoover, M.D., Sc.D., Division of Cancer Epidemiology and Genetics, National Cancer Institute
Do epidemiologic observations provide a consistent picture regarding biologic mechanisms underlying relationships of reproductive factors to breast cancer risk?
Laboratory Keynote--Jose Russo, M.D., Fox Chase Cancer Center
Breast development: Normal molecular and cellular biologic events, rodents vs. humans

February 25, 2003 - Bethesda Marriott Pooks Hill, Congressional Ballroom

Pregnancy-related factors: Risk of breast cancer and biologic correlates in human populations

7:00-8:00 a.m.

Continental Breakfast

8:00-8:05 a.m.

Moderator: Susan Love, M.D., Susan Love MD Breast Cancer Research Foundation

8:05-8:25 a.m.

Leslie Bernstein, Ph.D., University of Southern California, Keck School of Medicine
Pregnancy as it relates to breast cancer risk

8:25-8:45 a.m.

Paolo Toniolo, M.D., M.P.H., New York University School of Medicine
Endogenous hormones and proteins associated with pregnancy

8:45-9:05 a.m.

Janet Daling, Ph.D., Fred Hutchinson Cancer Research Center
Breast cancer tissue markers: Impact of pregnancy

9:05-9:20 a.m.

Questions and Answers

9:20-9:35 a.m.

Break

Pregnancy-related factors: Biologic correlates and breast cancer risk in animal models

9:35-9:40 a.m.

Moderator: Nancy Davidson, M.D., Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

9:40-10:00 a.m.

Barbara Vonderhaar, Ph.D., Center for Cancer Research, National Cancer Institute

Pregnancy hormones and tumor formation

10:00-10:20 a.m.

Daniel Medina, Ph.D., Baylor College of Medicine
Rodent models for protection from breast cancer by pregnancy

10:20-10:35 a.m.

Questions and Answers

10:35-10:50 a.m.

Break

Pregnancy-related risk factors: Biologic correlates from new technologies

10:50-10:55 a.m.

Moderator: Larry Norton, M.D., Memorial Sloan-Kettering Cancer Center

10:55-11:15 a.m.

Kay-Uwe Wagner, Ph.D., University of Nebraska Medical Center
Pregnancy and stem cell populations

11:15-11:35 a.m.

Lewis Chodosh, M.D., Ph.D., University of Pennsylvania
Using microarrays to understand parity-induced protection against breast cancer

11:35-11:55 a.m.

Norman Boyd, D.Sc., Ontario Cancer Institute, Princess Margaret Hospital
Changes in biologic surrogate endpoints associated with pregnancy

11:55 a.m.-12:10 p.m.

Questions and Answers

12:10-1:10 p.m.

Lunch

Discussion of Unpublished Materials

1:10-1:15 p.m.

Co-Moderators: Martin Abeloff, M.D., Sidney Kimmel Comprehensive Cancer
Center at Johns Hopkins
Carolyn Runowicz, M.D., University Hospital of Columbia University College of Physicians and Surgeons

1:15-2:15 p.m.

Presentation of new scientific data
Polly Newcomb, Ph.D., M.P.H., Fred Hutchinson Cancer Research Center
Mads Melbye, M.D., D.M.Sc., Statens Serum Institut
Dwight Janerich, D.D.S., M.P.H., University of Albany (NY)
Herbert Jacobson, Ph.D., Albany Medical College
Michael Pollak, M.D., McGill University
Charlotte Kuperwasser, Ph.D., Whitehead Institute
Leena Hilakivi-Clarke, Ph.D., Georgetown University
Satyabrata Nandi, Ph.D., University of California at Berkeley

2:15-2:45 p.m.

Break

Small-group sessions
Group Leaders:
Peggy Neville, Ph.D., University of Colorado Health Sciences Center
Sandra Haslam, Ph.D., Michigan State University
Satyabrata Nandi, Ph.D., University of California at Berkeley
Eugenia Calle, Ph.D., American Cancer Society
Lynn Rosenberg, Sc.D., Boston University School of Public Health
Dimitrios Trichopoulos, M.D., Ph.D., Harvard University School of Public Health
Anders Ekbom, M.D., Ph.D., Karolinska Institute
Dan Medina, Ph.D., Baylor College of Medicine

2:45-5:30 p.m.

Four breakout groups to discuss unresolved questions and ways of answering these questions.

• What do we know and what do we not know about the impact of pregnancy on breast cancer risk?

• From human population studies, and which pregnancy-related factors are established breast cancer risk factors, which have been suggested by data but need further pursuit and exploration
• From laboratory investigations, and which potential underlying mechanisms to explain pregnancy-related risk factors are most promising, which need further pursuit and exploration
• Which epidemiologic findings should be pursued in laboratory studies, and which laboratory findings should be pursued in epidemiologic investigations
• Are there specific interdisciplinary studies (incorporation of a laboratory component in an epidemiologic research design) which could substantially advance our knowledge and are feasible at this time
• Are there specific high-priority interdisciplinary studies that are not feasible at this time, and what would it take to establish their feasibility

• What is needed to implement the studies identified to fill the research gaps?

• Methodologic issues (both epidemiologic and laboratory) that need to be addressed
• Identification of uniquely informative populations for study
• Identification of important new technologies that should be utilized, refined further before utilization, or require development
• Development of epidemiologic and laboratory infrastructures, including consortia, that would enhance and facilitate interdisciplinary studies

Co-Chairs:

Peggy Neville, Ph.D., University of Colorado Health Sciences Center
Dimitrios Trichopoulos, M.D., Ph.D., Harvard School of Public Health

7:30-9:00 p.m.

Session for group leaders to develop a draft overall summary of challenges and opportunities

February 26, 2003

7:00-7:45 a.m.

Continental Breakfast at Bethesda Marriott Pooks Hill - Maryland Suites

7:45 a.m.

Shuttles from Bethesda Marriott to NIH Campus

NIH Campus, Building 10, Lipsett Auditorium

Moderators: Martin Abeloff, M.D., Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Carolyn Runowicz, M.D., University Hospital of Columbia University College of Physicians and Surgeons
Co-Chairs: Peggy Neville, Ph.D., University of Colorado Health Sciences Center
Dimitrios Trichopoulos, M.D., Ph.D., Harvard School of Public Health

8:30-10:30 a.m.

Presentation of draft overall summary with comments by group leaders followed by open discussion

10:30-11:15 a.m.

Break during which meeting and group leaders will meet to alter draft summary, if appropriate, based on discussion

11:15-11:45 a.m.

Presentation of final summary with opportunity for final comments from participants

11:45 a.m.

Adjourn

12:00 p.m.

Shuttles from NIH Campus to Bethesda Marriott

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