Clinical Trials: Reproductive-Related Mood Disorders

FEATURED STUDIES

Combined Hormone Replacement in Menstrually-Related Mood Disorders.
Treatment study, outpatient. The purpose of this 2-6 month study is to determine whether the maintenance of stable hormone levels will prevent mood disturbances in women with premenstrual syndrome (PMS). Ages 18-50. NIH Clinical Center, Bethesda, MD.

Clinical Trial of Leuprolide Acetate for the Treatment of PMS.
Treatment study, outpatient. This study examines the influence of estrogen and progesterone on mood and behavior in women with premenstrual syndrome (PMS). Ages 18-40. NIH Clinical Center, Bethesda, MD.

Interpersonal Psychotherapy for Postpartum Depression.
Treatment study; outpatient. This 12-week study will evaluate the effectiveness of Clinician-Managed Interpersonal Psychotherapy (CM-IPT) in treating postpartum depression and will compare CM-IPT to standard IPT. Ages 18 and older. Iowa City, IA.

Premenstrual Syndrome (PMS).
Evaluation and treatment studies; outpatient. These studies aim to determine the endocrine changes that may be responsible for changes in mood and behavior during the premenstrual period, evaluate treatments for PMS symptoms, and identify genetic factors related to PMS. Ages 18-50. NIH Clinical Center, Bethesda, MD.

Perimenopause-Related Mood Disorders.
Evaluation study; outpatient. This study investigates mood and behavior changes in the time period surrounding and including menopause. Participants will not receive any new or experimental therapies. Ages 40-60. NIH Clinical Center, Bethesda, MD.

Clinical Trial for Perimenopause-Related Depression.
Treatment study; outpatient. This 8-week study compares the effectiveness of the medication raloxifene (Evista®), red clover extract (Rimostil®), and estradiol (Alora®) to placebo in treating depression occurring in the time period surrounding and including menopause. Ages 40-60. NIH Clinical Center, Bethesda, MD.

Hormone Replacement Therapy (HRT) & Mood Symptoms.
Evaluation study; outpatient. This 6-week study investigates whether mood, anxiety, or irritability occur when women stop taking HRT. Ages 45-55, currently on HRT or estrogen therapy with plans to stop. NIH Clinical Center, Bethesda, MD.

Postpartum Depression.
Evaluation study, outpatient.This 12-week study aims to determine how women who have experienced postpartum depression respond to estrogen and progesterone in comparison to women who have not experienced mood disorders. Ages 18-40. NIH Clinical Center, Bethesda, MD.

Evaluation of Postpartum Depression.
Evaluation study; outpatient. This study explores the relationship between mood and hormones in postpartum depression. Participants will not receive any new or experimental therapies. Ages 20-45. NIH Clinical Center, Bethesda, MD.

Clinical Trial of Estrogen for Postpartum Depression.
Treatment study; outpatient. This 6-week study tests the effectiveness of estrogen in treating postpartum depression. Ages 20-45. NIH Clinical Center, Bethesda, MD.

Additional NIH Studies

Search ClinicalTrials.gov for more NIH/NIMH studies on Mood Disorders in Women

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