B.S., University of Nebraska, 1980
M.D., Stanford University, 1985
Research Statement
A major laboratory focus involves understanding normal and abnormal human erythropoiesis at the molecular level. For this purpose, we have developed a flow cytometric-based approach to isolate and culture erythropoietin responsive progenitor cells from human blood. Molecular and cell biology correlates are being performed by functional genomic analyses. Related studies include the development of genetic and pharmaceutical therapies for diseases involving erythroid cells.
Back to Top
Publications
1. Miller JL A genome-based approach for the study of erythroid biology and disease. Blood Cells Mol Dis (32): 341-3, 2004. [Full Text/Abstract]
2. Bhanu NV Trice TA Lee YT Miller JL A signaling mechanism for growth-related expression of fetal hemoglobin. Blood (103): 1929-33, 2004. [Full Text/Abstract]
3. Bhanu NV, Trice TA, Lee YT, Gantt N, Oneal P, Schwartz JD, Noel P, Miller JL A sustained and pancellular reversal of gamma-globin gene silencing in adult human erythroid precursor cells. Blood 2004. [Full Text/Abstract]
4. Aerbajinai W Lee YT Wojda U Barr VA Miller JL Cloning and characterization of a gene expressed during terminal differentiation that encodes a novel inhibitor of growth. J Biol Chem (279): 1916-21, 2004. [Full Text/Abstract]
5. Goh SH Lee YT Bouffard GG Miller JL Hembase: browser and genome portal for hematology and erythroid biology. Nucleic Acids Res (32 Database issue): D572-4, 2004. [Full Text/Abstract]
6. Pal S Nemeth MJ Bodine D Miller JL Svaren J Thein SL Lowry PJ Bresnick EH Neurokinin-B transcription in erythroid cells: Direct activation by the hematopoietic transcription factor GATA-1. J Biol Chem 2004. [Full Text/Abstract]
7. Stroncek DF Njoroge JM Procter JL Childs RW Miller J A preliminary comparison of flow cytometry and tube agglutination assays in detecting red blood cell-associated C3d. Transfus Med (13): 35-41, 2003. [Full Text/Abstract]
8. Wojda U Leigh KR Njoroge JM Jackson KA Natarajan B Stitely M Miller JL Fetal hemoglobin modulation during human erythropoiesis: stem cell factor has Blood (101): 492-7, 2003. [Full Text/Abstract]
9. Cokic VP Smith RD Beleslin-Cokic BB Njoroge JM Miller JL Gladwin MT Schechter AN Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase. J Clin Invest (111): 231-9, 2003. [Full Text/Abstract]
10. Aerbajinai W Giattina M Lee YT Raffeld M Miller JL The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation. Blood (102): 712-7, 2003. [Full Text/Abstract]
1 2 3 4 5 6 Next >>
