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The Imaging Sciences Laboratory (ISL)

  1. Develops and applies advanced imaging methods and algorithms to biomedical images which range from the entire body to the molecular level.
  2. Creates and implements innovative software technology for clinical, animal, and laboratory imaging.
  3. Collaborates in the design and implementation of computational techniques for microscopic imaging and biomolecular structure determination.
  4. Advances the application of high-performance computing to computationally demanding imaging problems.
  5. Manages the CIT Image Processing Facility (IPF), which provides software to the NIH Institutes.
  6. Consults and collaborates with NIH intramural researchers to share computing methods, technologies, and ideas for new imaging methodologies.

The ISL is loosely divided into one section and one group.

  • The Biomedical Imaging Research Services Section (BIRSS) is responsible for the continued development of a sophisticated image processing and visualization application that is comprehensive, extensible, and platform-independent. This application provides the foundation and tools needed to assist NIH intramural researchers with the processing of hypothesis-driven research data. Development includes the implementation of known solutions, algorithms, or methods to quickly and efficiently meet the needs of our collaborators. However, to meet unique requirements, the group develops novel methods and algorithms.

  • The Imaging Science in Structural Biology Group (ISSBG) is responsible for the applications of imaging science to structural biology. This includes developing new applications, creating new algorithms, and collaborating with intramural research scientists. Collaborations include structural biology, virology, electron microscopy, NMR spectroscopy, 3-dimensional reconstruction methods, optimization theory, high-performance computing, and imaging science.


Imaging Science Laboratory
Division of Computational Bioscience
Center for Information Technology
National Institutes of Health
Building 12A, Room 2033
Bethesda, MD 20892-5626


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