CCBB, under the direction of Dr. Barbara Spalholz, encourages and supports basic research projects covering a broad spectrum of topics directed at understanding the biological basis of cancer. The Branch portfolio includes the search for genes, proteins and networks responsible for the cancer phenotype, investigation of aberrantly modified regulatory processes that promote cell proliferation or inhibit cell death, and the identification of connecting pathways that ensure tumor cell survival. The research utilizes non-mammalian organisms as well as mammalian models to undertake the functional analysis of abnormal genetic expression or genetic loss, in parallel with studies on human tumor cells and tissues to confirm the physiological relevance of the research findings. Other areas of special focus include the subcellular location and trafficking of proteins in the cell, cellular processes of proteolysis, the basis of genetic resistance and susceptibility, and the biology of tumor angiogenesis. Investigations in all tumor cell types are included. The ultimate goal of the Cancer Cell Biology program is the discovery of new information that has practical application to disease detection or treatment.
 |
| PA-03-041 | -HIGH-IMPACT PILOT STUDIES IN CANCER BIOLOGY |
| PA-03-145 | -UBIQUITIN AND UBIQUITIN-LIKE MODIFICATIONS REGULATING DISEASE PROCESSES |
| PA-04-125 | -NOVEL APPROACHES TO ENHANCE ANIMAL STEM CELL RESEARCH |
| |
| Name | Title |
| Spalholz, Barbara, Ph.D. | Chief |
| Blair, Donald, Ph.D. | Program Director |
| Perry, Mary Ellen, Ph.D. | Program Director |
| Yassin, Rihab, Ph.D. | Program Director |
| Strasburger, Jennifer | Program Administrator |
| Agyemann, Nailah | Grants Technical Assistant |
| Kave, Joyce | Grants Technical Assistant |
|
|
 |
 |
| Molecular Biology |
The Molecular Biology program area, directed by Dr. Mary Ellen Perry supports studies on the functional analysis of cancer genes; growth factor/receptor interactions in tumor cells and their pathways of growth stimulation, and mechanisms of subcellular protein localization and regulation of trafficking systems.
|
| Genetics |
The Genetics program area supports research on the regulation of expression of cancer genes by transcription and post-transcriptional processing; mechanisms of tumor suppressor function; the generation and characterization of nonmammalian and mammalian (murine) genetic models of inherited and sporadic malignancies; analysis of complex traits and gene networks, and identification of modifier loci.
|
| Cell Biology |
The Cell Biology program area, directed by Dr. Barbara Spalholz, supports basic molecular biology studies on the cell cycle; the multi-step process of DNA replication and cell division; the analysis of programmed cell death, and cellular signaling by lipids in tumor cells. Emphasis is focused on the failure of normal processes and controls that then leads to tumorigenesis.
|
| Signal Transduction |
The Signal Transduction program area, directed by Dr. Donald Blair, supports studies on the biology of cell signaling and how signaling is altered in the neoplastic state; analysis of the roles of various mitogenic oncogenes, intermediate signaling molecules, vitamins, and includes other mediators of tumor growth or cellular differentiation.
|
| Conference and SBIR/STTR Grants |
The program of conference grants and Small Business Innovation Research Grants is directed by Ms. Jennifer Strasburger.
|
|
|
