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Pamela L. Schwartzberg, M.D., Ph.D.
Selected Publications
Debnath J, Chamorro M, Czar MJ, Schaeffer EM, Lenardo MJ, Varmus HE, Schwartzberg PL. rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases. Mol Cell Biol, 19(2):1498-507. 1999. [PubMed]
Schaeffer EM, Debnath J, Yap G, McVicar D, Liao XC, Littman DR, Sher A, Varmus HE, Lenardo MJ, Schwartzberg PL. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science, 284(5414):638-41. 1999. [PubMed]
Schaeffer E, Broussard C, Debnath J, Anderson S, McVicar D, Schwartzberg P. Tec family kinases modulate thresholds for thymocyte development and selection. J Exp Med, 192:987-1000. 2000. [PubMed]
Xing L, Venegas A, Chen A, Garrett L, Boyce B, Varmus HE, Schwartzberg PL. Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival. Genes Dev, 15:241-253. 2001. [PubMed]
Czar MJ, Kersh EN, Mijares LA, Lanier G, Lewis J, Yap G, Chen A, Sher A, Duckett CS, Ahmed R, Schwartzberg PL. Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP. Proc Natl Acad Sci U S A, 98:7449-54. 2001. [PubMed]
Schaeffer EM, Yap GS, Lewis CM, Czar MJ, McVicar DW, Cheever AW, Sher A, Schwartzberg PL. Mutation of Tec family kinases alters T helper cell differentiation. Nat Immunol, 2:1183-8. 2001. [PubMed]
Crotty S, Kersh EN, Cannons J, Schwartzberg PL, Ahmed R. SAP is required for generating long-term humoral immunity. Nature, 16;421(6920):282-7. 2003. [PubMed]
Last Updated: June 2004
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