Prepared by:
San Antonio Evidence-based Practice Center based at the University of Texas Health Science Center at San Antonio and the Veterans Evidence-based Research, Dissemination, and Implementation Center, a Veterans Affairs Health Services Research and Development Center of Excellence
Cynthia Mulrow, M.D., M.Sc.
Program Director
Valerie Lawrence, M.D., M.Sc.
Principal Investigator
Ronald Ackermann, M.D.
Gilbert Ramirez, Dr.P.H.
Laura Morbidoni, M.D.
Christine Aguilar, M.D., M.P.H.
Jennifer Arterburn, M.T.S.C.
Erick Block, Ph.D.
Elaine Chiquette, Pharm.D.
Christopher Gardener, Ph.D.
Martha Harris, M.L.S., M.A.
Paul Heidenreich, M.D., M.S.
David Mullins
MaryAnn Richardson, Dr.P.H.
Nancy Russell, M.P.H.
Andrew Vickers, M.D.
Veonica Young, Pharm.D.
File Name Description Software Version File Size __________________________________________________________________________________________________ 01title.doc Microsoft Word® Document MS Word® 97 SR-1 27KB 3 pages Contents: Cover Page, Title Page __________________________________________________________________________________________________ 02front.doc Microsoft Word® Document MS Word® 97 SR-1 34KB 5 pages Contents: Preface, Structured Abstract, Table of Contents __________________________________________________________________________________________________ 03summ.doc Microsoft Word® Document MS Word® 97 SR-1 48KB 6 pages Contents: Overview, Reporting the Evidence, Methodology, Findings, Limitations, Future Research __________________________________________________________________________________________________ 04intro.doc Microsoft Word® Document MS Word® 97 SR-1 201KB 10 pages Contents: Chapter 1. Introduction: Scope and Objectives, Origins and Folklore of Garlic, Chemistry of Garlic, Figure 1. Chemical profile of garlic, Historical Uses of Garlic, Garlic Research Addressing Cardiovascular-Related Factors and Disease, Garlic Research Addressing Cancer, Garlic Preparations, Table 1. Historical examples of different preparations of garlic, Summary of Challenges in Conducting and Interpreting Garlic Research in Humans, Table 2. Summary points about garlic __________________________________________________________________________________________________ 05method.doc Microsoft Word® Document MS Word® 97 SR-1 172KB 10 pages Contents: Chapter 2. Methodology: Expert Input, Questions Addressed in Evidence Report, Table 3. Questions and selection criteria grouped by search strategies, Literature Search and Selection Methods, Table 4. Electronic sources searched, Selection Processes, Figure 2. Flow diagram of selection process, Data Abstraction Process, Unpublished Data, Data Analysis Process, Sensitivity and Subgroup Analysis, Presentation of Results __________________________________________________________________________________________________ 06result.doc Microsoft Word® Document MS Word® 97 SR-1 511KB 30 pages Contents: Chapter 3. Results: Cardiovascular Risks and Disease, (Table 5 in separate file) Figure 3. Galbraith plot of studies with total cholesterol results at 4 to 6 weeks, Figure 4. Funnel plot of studies with total cholesterol results at 4 to 6 weeks, Figure 5. Galbraith plot of studies with total cholesterol results at 8 to 12 weeks, Figure 6. Funnel plot of studies with total cholesterol results at 8 to 12 weeks, Figure 7. Galbraith plot of studies with total cholesterol results at 20 to 24 weeks, Figure 8. Funnel plot of studies with total cholesterol results at 20 to 24 weeks, (Figures 9-12 in separate files) Associations With Cancer, Adverse Effects of Garlic __________________________________________________________________________________________________ 07tbl5.doc Microsoft Word® Document MS Word® 97 SR-1 125KB 3 pages Contents: Contents: Table 5. Characteristics of trials that evaluated standardized dehydrated garlic powder preparations (Chapter 3) __________________________________________________________________________________________________ 08f9-12.doc Microsoft Word® Document MS Word® 97 SR-1 223KB 5 pages Contents: Figure 9. Forest plot of studies with total cholesterol results at 4 to 6 weeks, Figure 10. Forest plot of studies with total cholesterol results at 8 to 12 weeks, Figure 11. Forest plot of studies with total cholesterol results at 20 to 24 weeks, Figure 12. Forest plot of pooled results of total cholesterol findings at different time periods (Chapter 3) __________________________________________________________________________________________________ 09conclu.doc Microsoft Word® Document MS Word® 97 SR-1 31KB 4 pages Contents: Chapter 4. Conclusions: Garlic and Cardiovascular Disease Summary Points, Garlic and Cancer Summary Points, Adverse Effects Summary Points, Limitations __________________________________________________________________________________________________ 10future.doc Microsoft Word® Document MS Word® 97 SR-1 24KB 2 pages Contents: Chapter 5. Future Research Directions: Equivalency of Garlic Preparations, Proper Placebos, Cardiovascular-Related Effects, Cancer-Related Associations, Adverse Effects, Interactions __________________________________________________________________________________________________ 11refs.doc Microsoft Word® Document MS Word® 97 SR-1 74KB 10 pages Contents: References __________________________________________________________________________________________________ 12etbl1.doc Microsoft Word® Document MS Word® 97 SR-1 158KB 5 pages Contents: Evidence Table 1. Overview of randomized trials with cardiovascular endpoints that were 4 weeks or longer in duration and compared garlic with placebo or other therapy __________________________________________________________________________________________________ 13etbl2.doc Microsoft Word® Document MS Word® 97 SR-1 125KB 3 pages Contents: Evidence Table 2. Characteristics of trials that evaluated nonstandardized garlic preparations __________________________________________________________________________________________________ 14etbl3.doc Microsoft Word® Document MS Word® 97 SR-1 133KB 5 pages Contents: Evidence Table 3. Results of trials reporting blood pressure outcomes after garlic supplementation __________________________________________________________________________________________________ 15etbl4.doc Microsoft Word® Document MS Word® 97 SR-1 116KB 2 pages Contents: Evidence Table 4. Results of trials assessing effect of garlic supplementation on serum glucose __________________________________________________________________________________________________ 16etbl5.doc Microsoft Word® Document MS Word® 97 SR-1 124KB 3 pages Contents: Evidence Table 5. Reported results from trials assessing the effect of garlic supplementation on thrombotic factors __________________________________________________________________________________________________ 17etbl6.doc Microsoft Word® Document MS Word® 97 SR-1 108KB 2 pages Contents: Evidence Table 6. Summary of associations between garlic and cancer __________________________________________________________________________________________________ 18etbl7.doc Microsoft Word® Document MS Word® 97 SR-1 20KB 1 page Contents: Evidence Table 7. Summary of associations between garlic and precancerous conditions __________________________________________________________________________________________________ 19etbl8.doc Microsoft Word® Document MS Word® 97 SR-1 134KB 8 pages Contents: Evidence Table 8. Studies addressing protective associations between garlic and cancer __________________________________________________________________________________________________ 20etbl9.doc Microsoft Word® Document MS Word® 97 SR-1 21KB 1 page Contents: Evidence Table 9. Summary of adverse effects __________________________________________________________________________________________________ 21biblio.doc Microsoft Word® Document MS Word® 97 SR-1 184KB 15 pages Contents: Bibliography __________________________________________________________________________________________________ 22appa.doc Microsoft Word® Document MS Word® 97 SR-1 345KB 10 pages Contents: Contents: Appendix A. Supplemental Figures: Figure A-1. LDL, 8 to 12 weeks, Galbraith plot Figure A-2. LDL, 8 to 12 weeks, funnel plot Figure A-3. LDL, 8 to 12 weeks, forest plot Figure A-4. HDL, 8 to 12 weeks, Galbraith plot Figure A-5. HDL, 8 to 12 weeks, funnel plot Figure A-6. HDL, 8 to 12 weeks, forest plot Figure A-7. Triglyceride, 8 to 12 weeks, Galbraith plot Figure A-8. Triglyceride, 8 to 12 weeks, funnel plot Figure A-9. Triglyceride, 8 to 12 weeks, forest plot __________________________________________________________________________________________________ 23appb.doc Microsoft Word® Document MS Word® 97 SR-1 37KB 6 pages Contents: Appendix B. Contributors __________________________________________________________________________________________________ 24appc.doc Microsoft Word® Document MS Word® 97 SR-1 21KB 2 pages Contents: Appendix C. Acronyms and Abbreviations __________________________________________________________________________________________________
AHRQ Publication No. 01-E023
Current as of October 2000
Internet Citation:
Garlic: Effects on Cardiovascular Risks and Disease, Protective Effects Against Cancer, and Clinical Adverse Effects. File Inventory, Evidence Report/Technology Assessment Number 20. AHRQ Publication No. 01-E023, October 2000. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/clinic/garlcinv.htm
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