Complementary and Alternative Care: Dietary Supplements
S-Adenosyl-L-Methionine (SAMe) for Depression, Osteoarthritis, and Liver Disease
August 2002
Clinical Focus*
- What study reports were available on the use of SAMe for depression, ostheoarthritis, and liver disease?
- What types of outcomes were measured for the identified conditions?
- How did results for treatment with SAMe compare to placebo and conventional pharmacology?
- What non-English language publications on SAMe treatment are available and accessible?
- What is the methodological quality of the studies identified?
- Can results be pooled to allow a risk ratio and an effect size for SAMe to be calculated?
*Addressed in the summary or evidence report.
S-Adenosyl-L-Methionine (SAMe) for Depression, Osteoarthritis, and Liver Disease
Summary (Publication No. 02-E033, August 2002)
Evidence Report (Publication No. 02-E033, October 2002)
(File Download)
EPC: Southern California-RAND
Topic Nominator: National Center for Complementary and Alternative Medicine (NCCAM)
Return to Quick Menu: Evidence Report Topics
Return to Evidence-based Practice