Evidence Report/Technology Assessment Number 83

Effect of Supplemental Antioxidants Vitamin C, Vitamin E, and Coenzyme Q10 for the Prevention and Treatment of Cardiovascular Disease

File Inventory


Prepared by:

Southern California-RAND Evidence-based Practice Center
Santa Monica, CA

Program Directors
   Paul Shekelle, M.D., Ph.D.
   Sally C. Morton, Ph.D.
Project Directors
   Mary Hardy, M.D.
   Ian Coulter, Ph.D.
Physician Reviewers
   Jay Udani, M.D.
   Myles Spar, M.P.H., M.D.
   Karen Oda, M.D.
Programmer/Analyst
   Lara K. Jungvig, B.A.
Statisticians
   Wenli Tu, M.S.
   Marika J. Suttorp, MS
Staff Assistants
   Di Valentine, J.D.
   Louis Ramirez, B.A.
Reference Librarian
   Roberta Shanman, M.L.S.
Editor
   Sydne J. Newberry, Ph.D.


File Name	Description			Software	Version	File	Size
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01front.doc	Microsoft Word® Document	MS Word®	2002	56KB	6 pages
Contents: Title Page, Preface, Structured Abstract
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02conts.doc	Microsoft Word® Document	MS Word®	2002	36KB	4 pages
Contents: Table of Contents
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03summ.doc	Microsoft Word® Document	MS Word®	2002	35KB	4 pages
Contents: Summary: Overview, Methodology, Findings, Future Research
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04chap1.doc	Microsoft Word® Document	MS Word®	2002	128KB	11 pages
Contents: Chapter 1. Introduction: Purpose, Specific Aims, Cardiovascular Disease, 
Antioxidants and Cardiovascular Disease
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05fig1.doc	Microsoft Word® Document	MS Word®	2002	56KB	1 page
Contents: Figure 1. Vitamin C
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06fig2.doc	Microsoft Word® Document	MS Word®	2002	407KB	1 page
Contents: Figure 2. Vitamin E
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07fig3.doc	Microsoft Word® Document	MS Word®	2002	77KB	1 page
Contents: Figure 3. Coenzyme Q10
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08chap2.doc	Microsoft Word® Document	MS Word®	2002	51KB	7 pages
Contents: Chapter 2. Methodology: Scope of Work, Objective, Literature Search Design, 
Evaluation of Evidence
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09tbl1.doc	Microsoft Word® Document	MS Word®	2002	34KB	1 page
Contents: Table 1. Biomedical and Other Databases Searched
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10tbl2.doc	Microsoft Word® Document	MS Word®	2002	29KB	1 page
Contents: Table 2. Additional Search Terms for Antioxidants Studied
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11tbl3.doc	Microsoft Word® Document	MS Word®	2002	31KB	1 page
Contents: Table 3. Summary of Search Strategy
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12fig4.doc	Microsoft Word® Document	MS Word®	2002	33KB	1 page
Contents: Figure 5. Vitamin E Alone vs. Placebo: All-cause Mortality
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13tbl4.doc	Microsoft Word® Document	MS Word®	2002	50KB	1 page
Contents: Table 4. Outcomes Reported for Vitamin C Studies (n=37)
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14tbl5.doc	Microsoft Word® Document	MS Word®	2002	58KB	1 page
Contents: Table 5. Outcomes Reported for Coenzyme Q10 Studies (n=54)
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15chap3.doc	Microsoft Word® Document	MS Word®	2002	234KB	21 pages
Contents: Chapter 3. Results: Description of the Evidence, Details of the "Named" 
Clinical Trials Included in Analysis, Vitamin E Trials That Report Death as an Outcome, 
Vitamin E Trials That Report on Myocardial Infarction as an Outcome, Vitamin E Trials That 
Reported on Lipids as an Outcome, Trials that Report on the Effect of Coenzyme Q10 
Supplementation on Cardiovascular Disease Outcomes, Trials that Report on the Effect of 
Vitamin C Supplementation on Cardiovascular Disease Outcomes
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16tbl6.doc	Microsoft Word® Document	MS Word®	2002	336KB	6 pages
Contents: Table 6. Primary, secondary, and treatment trials
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17tbl7.doc	Microsoft Word® Document	MS Word®	2002	66KB	1 page
Contents: Table 7. Risk Ratios for Vitamin E Alone vs. Placebo: All-Cause Mortality
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18fig5.doc	Microsoft Word® Document	MS Word®	2002	43KB	1 page
Contents: Figure 5. Vitamin E Alone vs. Placebo: All-cause Mortality
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19tbl8.doc	Microsoft Word® Document	MS Word®	2002	35KB	1 page
Contents: Table 8. Publication Bias Test Results
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20fig6.doc	Microsoft Word® Document	MS Word®	2002	36KB	1 page
Contents: Figure 6. Vitamin E in Combination vs. Placebo: All-cause Mortality
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21tbl9.doc	Microsoft Word® Document	MS Word®	2002	49KB	1 page
Contents: Table 9. Risk Ratios for Vitamin E in Combination vs. Placebo: All-Cause Mortality
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22tbl10.doc	Microsoft Word® Document	MS Word®	2002	42KB	1 page
Contents: Table 10. Risk Ratios for Vitamin E Alone vs. Placebo: Cardiovascular Deaths
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23fig7.doc	Microsoft Word® Document	MS Word®	2002	42KB	1 page
Contents: Figure 7. Vitamin E Alone vs. Placebo: Cardiovascular deaths
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24fig8.doc	Microsoft Word® Document	MS Word®	2002	36KB	1 page
Contents: Figure 8. Publication Bias - Vitamin E Alone vs. Placebo: Cardiovascular deaths
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25tbl11.doc	Microsoft Word® Document	MS Word®	2002	58KB	1 page
Contents: Table 11. Risk Ratios for Vitamin E in Combination vs. Placebo: Cardiovascular Deaths
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26fig9.doc	Microsoft Word® Document	MS Word®	2002	41KB	1 page
Contents: Figure 9. Vitamin E in Combination vs. Placebo: Cardiovascular deaths
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27fig10.doc	Microsoft Word® Document	MS Word®	2002	36KB	1 page
Contents: Figure 10. Publication Bias - Vitamin E in Combination vs. Placebo: 
Cardiovascular Deaths
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28tbl12.doc	Microsoft Word® Document	MS Word®	2002	62KB	1 page
Contents: Table 12. Risk Ratios for Vitamin E Alone vs. Placebo: Fatal Myocardial infarction
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29fig11.doc	Microsoft Word® Document	MS Word®	2002	42KB	1 page
Contents: Figure 11. Vitamin E Alone vs. Placebo: Fatal Myocardial Infarction
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30fig12.doc	Microsoft Word® Document	MS Word®	2002	36KB	1 page
Contents: Figure 12. Publication Bias - Vitamin E Alone vs. Placebo: 
Fatal Myocardial Infarction
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31tbl13.doc	Microsoft Word® Document	MS Word®	2002	56KB	1 page
Contents: Table 13. Risk Ratios for Vitamin E in Combination vs. Placebo: 
Fatal Myocardial infarction
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32fig13.doc	Microsoft Word® Document	MS Word®	2002	42KB	1 page
Contents: Figure 13. Vitamin E in Combination vs. Placebo: Fatal Myocardial Infarction
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33fig14.doc	Microsoft Word® Document	MS Word®	2002	36KB	1 page
Contents: Figure 14. Publication Bias - Vitamin E in Combination vs. Placebo: 
Fatal Myocardial Infarction
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34tbl14.doc	Microsoft Word® Document	MS Word®	2002	58KB	1 page
Contents: Table 14. Risk Ratios for Vitamin E Alone vs. Placebo: 
Nonfatal Myocardial infarction
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35fig15.doc	Microsoft Word® Document	MS Word®	2002	42KB	1 page
Contents: Figure 15. Vitamin E Alone vs. Placebo: Nonfatal Myocardial Infarction
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36fig16.doc	Microsoft Word® Document	MS Word®	2002	36KB	1 page
Contents: Figure 16. Publication Bias - Vitamin E Alone vs. Placebo: 
Nonfatal Myocardial Infarction
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37tbl15.doc	Microsoft Word® Document	MS Word®	2002	63KB	1 page
Contents: Table 15. Risk Ratios for Vitamin E in Combination vs. Placebo: 
Nonfatal Myocardial infarction
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38fig17.doc	Microsoft Word® Document	MS Word®	2002	41KB	1 page
Contents: Figure 17. Vitamin E in Combination vs. Placebo: Nonfatal Myocardial Infarction
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39fig18.doc	Microsoft Word® Document	MS Word®	2002	36KB	1 page
Contents: Figure 18. Publication Bias - Vitamin E in Combination vs. Placebo: 
Nonfatal Myocardial Infarction
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40tbl16.doc	Microsoft Word® Document	MS Word®	2002	76KB	1 page
Contents: Table 16. Risk Ratios for Vitamin E Alone vs. Placebo: Total Cholesterol Level
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41fig19.doc	Microsoft Word® Document	MS Word®	2002	53KB	1 page
Contents: Figure 19. Vitamin E Alone vs. Placebo: Total Cholesterol Level
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42fig20.doc	Microsoft Word® Document	MS Word®	2002	37KB	1 page
Contents: Figure 20. Publication Bias - Vitamin E Alone vs. Placebo: Total Cholesterol Level
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43tbl17.doc	Microsoft Word® Document	MS Word®	2002	74KB	1 page
Contents: Table 17. Risk Ratios for Vitamin E Alone vs. Placebo: Low-Density Lipoprotein
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44fig21.doc	Microsoft Word® Document	MS Word®	2002	52KB	1 page
Contents: Figure 21. Vitamin E Alone vs. Placebo: Low-density Lipoprotein
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45fig22.doc	Microsoft Word® Document	MS Word®	2002	37KB	1 page
Contents: Figure 22. Publication Bias - Vitamin E Alone vs. Placebo: Low-density Lipoprotein
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46tbl18.doc	Microsoft Word® Document	MS Word®	2002	75KB	1 page
Contents: Table 18. Risk Ratios for Vitamin E Alone vs. Placebo: High-Density Lipoprotein
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47fig23.doc	Microsoft Word® Document	MS Word®	2002	53KB	1 page
Contents: Figure 23. Vitamin E Alone vs. Placebo: High-density Lipoprotein
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48fig24.doc	Microsoft Word® Document	MS Word®	2002	37KB	1 page
Contents: Figure 24. Publication Bias - Vitamin E Alone vs. Placebo: High-density Lipoprotein
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49tbl19.doc	Microsoft Word® Document	MS Word®	2002	59KB	1 page
Contents: Table 19. Risk Ratios for Vitamin E in Combination vs. Placebo: 
Total Cholesterol Level
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50fig25.doc	Microsoft Word® Document	MS Word®	2002	47KB	1 page
Contents: Figure 25. Vitamin E in Combination vs. Placebo: Total Cholesterol Level
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51fig26.doc	Microsoft Word® Document	MS Word®	2002	36KB	1 page
Contents: Figure 26. Publication Bias - Vitamin E in Combination vs. Placebo: 
Total Cholesterol Level
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52tbl20.doc	Microsoft Word® Document	MS Word®	2002	48KB	1 page
Contents: Table 20. Risk Ratios for Vitamin E in Combination vs. Placebo: 
Low-Density Lipoprotein
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53fig27.doc	Microsoft Word® Document	MS Word®	2002	45KB	1 page
Contents: Figure 27. Vitamin E in Combination vs. Placebo: Low-density Lipoprotein
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54fig28.doc	Microsoft Word® Document	MS Word®	2002	36KB	1 page
Contents: Figure 28. Publication Bias - Vitamin E in Combination vs. Placebo: 
Low-density Lipoprotein
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55tbl21.doc	Microsoft Word® Document	MS Word®	2002	49KB	1 page
Contents: Table 21. Risk Ratios for Vitamin E in Combination vs. Placebo: 
High-Density Lipoprotein
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56fig29.doc	Microsoft Word® Document	MS Word®	2002	45KB	1 page
Contents: Figure 29. Vitamin E in Combination vs. Placebo: High-density Lipoprotein
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57fig30.doc	Microsoft Word® Document	MS Word®	2002	35KB	1 page
Contents: Figure 30. Publication Bias - Vitamin E in Combination vs. Placebo: 
High-density Lipoprotein
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58chap4.doc	Microsoft Word® Document	MS Word®	2002	24KB	2 pages
Contents: Chapter 4. Limitations: Literature, Quality of Trials, Appropriateness of the 
Intervention and Population, Heterogeneity
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59chap5.doc	Microsoft Word® Document	MS Word®	2002	21KB	1 page
Contents: Chapter 5. Conclusions
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60chap6.doc	Microsoft Word® Document	MS Word®	2002	25KB	2 pages
Contents: Chapter 6. Future Research
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61refs.doc	Microsoft Word® Document	MS Word®	2002	87KB	15 pages
Contents: References
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62evtbl.doc	Microsoft Word® Document	MS Word®	2002	1.1MB	56 pages
Contents: Evidence Table. Antioxidants for Cardiovascular Prevention and Treatment
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63biblio.doc	Microsoft Word® Document	MS Word®	2002	157KB	20 pages
Contents: Bibliography
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64appa.doc	Microsoft Word® Document	MS Word®	2002	44KB	3 pages
Contents: Appendix A. Acknowledgments
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65appb.doc	Microsoft Word® Document	MS Word®	2002	46KB	6 pages
Contents: Appendix B. Search Methodology
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66appc.doc	Microsoft Word® Document	MS Word®	2002	31KB	1 page
Contents: Appendix C. Antioxidant Screener
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67appd.doc	Microsoft Word® Document	MS Word®	2002	229KB	8 pages
Contents: Appendix D. Quality Review Form
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68appe.doc	Microsoft Word® Document	MS Word®	2002	215KB	21 pages
Contents: Appendix E. Peer reviewer comments and responses
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AHRQ Publication No. 03-E043
Current as of July 2003


Internet Citation:

Effect of Supplemental Antioxidants Vitamin C, Vitamin E, and Coenzyme Q10 for the Prevention and Treatment of Cardiovascular Disease. File Inventory, Evidence Report/Technology Assessment Number 83. AHRQ Publication No. 03-E043, July 2003. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/clinic/aoxcardinv.htm


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