Evidence Report/Technology Assessment Number 19

Management of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

File Inventory


Prepared by:

Duke University Evidence-based Practice Center
Center for Clinical Health Policy Research

Douglas C. McCrory, M.D., M.H.Sc.
   Principal Investigator
Cynthia Brown, M.D.
Rebecca N. Gray, D.Phil.
Ruth E. Goslin, M.A.T.
Jane T. Kolimaga, M.A.
Neil R. MacIntyre, M.D.
Eugene Z. Oddone, M.D., M.H.Sc.
David B. Matchar, M.D.
   Investigators


File Name		Description			Software	Version		File	Size
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01title.doc		Microsoft Word® Document	MS Word®	97 SR-1		28KB	4 pages
Contents: Front Cover, Title Page
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02front.doc		Microsoft Word® Document	MS Word®	97 SR-1		49KB	6 pages
Contents: Preface, Structured Abstract, Table of Contents
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03summ.doc		Microsoft Word® Document	MS Word®	97 SR-1		91KB	8 pages
Contents: Summary
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04chap1.doc		Microsoft Word® Document	MS Word®	97 SR-1		83KB	7 pages
Contents: Chapter 1. Introduction: Purpose and Scope of Report; Incidence/Prevalence;
Natural History of Chronic Obstructive Pulmonary Disease; 
Table 1. Clinical staging of COPD - ATS 1995 guidelines; 
Burden of Illness; Disease Biology; Pertinent Clinical Features; 
Table 2. Clinical staging of COPD - European Respiratory Society, 1995; 
Table 3. Clinical staging of COPD - British Thoracic Society; 
Noninvasive Positive Pressure Ventilation; Target Populations; Practice Settings
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05chap2.doc		Microsoft Word® Document	MS Word®	97 SR-1		215KB	12 pages
Contents: Chapter 2. Methodology: Evidence Report Questions and Evidence Model; 
Literature Search and Review Parameters; 
Figure 1. Evidence model for management of acute exacerbations of COPD; 
Screening/Quality Rating Criteria and Selection Process; 
Table 4. Interrater agreement in citation screening; 
Table 5. Literature selection process by topic; 
Table 6. Literature identification by source database 
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06chap3.doc		Microsoft Word® Document	MS Word®	97 SR-1		1.3MB	42 pages
Contents: Chapter 3. Results: Clinical Assessment; Table 7. Outpatient studies of predictors; 
Table 8. Inpatient studies of predictors; Selected Treatment Strategies; 
Table 9. Characteristics of RCTs of antibiotics in acute exacerbations of COPD; 
Table 10. Dosage comparison of corticosteroid trials; 
Noninvasive Positive Pressure Ventilation; Figure 2. Noninvasive positive pressure masks; 
Figure 3. Monitoring of NPPV-treated patients; 
Table 11. Studies of characteristics and adverse effects of noninvasive 
positive pressure ventilation
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07chap4.doc		Microsoft Word® Document	MS Word®	97 SR-1		55KB	7 pages
Contents: Chapter 4. Conclusions: Clinical Assessment; Prognosis; Outpatient Studies; 
Inpatient Studies; Antibiotics; Bronchodilating Drugs; Corticosteroids; 
Mucous Clearance Strategies - Drugs and Physiotherapy; Noninvasive Positive Pressure Ventilation; 
Limitations of the Current Literature; Summary
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08chap5.doc		Microsoft Word® Document	MS Word®	97 SR-1		28KB	1 page
Contents: Chapter 5. Future Research
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09refs.doc		Microsoft Word® Document	MS Word®	97 SR-1		64KB	10 pages
Contents: References
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10etbl1.doc		Microsoft Word® Document	MS Word®	97 SR-1		102KB	13 pages
Contents: Evidence Table 1. Differential diagnosis and initial assessment of severity
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11etbl2.doc		Microsoft Word® Document	MS Word®	97 SR-1		155KB	26 pages
Contents: Evidence Table 2. Prognosis
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12etbl3.doc		Microsoft Word® Document	MS Word®	97 SR-1		120KB	17 pages
Contents: Evidence Table 3. Antibiotics
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13etbl4.doc		Microsoft Word® Document	MS Word®	97 SR-1		142KB	22 pages
Contents: Evidence Table 4. Bronchodilators
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14etbl5.doc		Microsoft Word® Document	MS Word®	97 SR-1		78KB	11 pages
Contents: Evidence Table 5. Corticosteroids
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15etbl6.doc		Microsoft Word® Document	MS Word®	97 SR-1		56KB	8 pages
Contents: Evidence Table 6. Mucolytics
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16etbl7.doc		Microsoft Word® Document	MS Word®	97 SR-1		48KB	5 pages
Contents: Evidence Table 7. Physical therapy
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17etabbs.doc		Microsoft Word® Document	MS Word®	97 SR-1		26KB	4 pages
Contents: Abbreviations Used in Evidence Tables
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18biblio.doc		Microsoft Word® Document	MS Word®	97 SR-1		168KB	29 pages
Contents: Bibliography
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19appa.doc		Microsoft Word® Document	MS Word®	97 SR-1		31KB	4 pages
Contents: Appendix A. Final Literature Search Strategies
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20appb.doc		Microsoft Word® Document	MS Word®	97 SR-1		29KB	2 pages
Contents: Appendix B. Screening/Data Abstraction Form
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21appc.doc		Microsoft Word® Document	MS Word®	97 SR-1		23KB	2 pages
Contents: Appendix C. Acronyms and Abbreviations Used in Report
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22etbl8.doc		Microsoft Word® Document	MS Word®	97 SR-1		154KB	15 pages
Contents: Evidence Table 8.  Noninvasive Positive Pressure Ventilation
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AHRQ Publication No. 01-E003
Current as of March 2001


Internet Citation:

Management of Acute Exacerbations of Chronic Obstructive Pulmonary Disease. File Inventory, Evidence Report/Technology Assessment Number 19. AHRQ Publication No. 01-E003, March 2001. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/clinic/copdinv.htm


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