Prepared by:
Blue Cross and Blue Shield Association Technology Evaluation Center
Carole Redding Flamm, M.D., M.P.H.
Principal Investigator
Naomi Aronson, Ph.D.
Rhonda Bohn, Sc.D., M.P.H.
Beth Finkelstein, Ph.D., M.P.H.
Margaret Piper, Ph.D., M.P.H.
Jerome Seidenfeld, Ph.D.
Claudia J. Bonnell, B.S.N., M.L.S.
Maurice Carter
Maxine Gere, M.S.
Kathleen M. Ziegler, Pharm. D.
Investigators
File Name Description Software Version File Size __________________________________________________________________________________________________________ 01front.doc Microsoft Word® Document MS Word® 97 SR-1 39KB 7 pages Contents: Cover, Title Page, Preface, Structured Abstract 02conts.doc Microsoft Word® Document MS Word® 97 SR-1 24KB 2 pages Contents: Table of Contents 03summ.doc Microsoft Word® Document MS Word® 97 SR-1 85KB 12 pages Contents: Summary: Overview; Reporting the Evidence; Methodology; Findings; Priorities for Future Research 04chap1.doc Microsoft Word® Document MS Word® 97 SR-1 70KB 11 pages Contents: Chapter 1. Introduction: Scope and Objectives; Key Questions; Background; Clinical Practice Guidelines for Anemia in Chronic Renal Failure; Epoetin; Table 1. FDA-approved uses of epoetin alfa and dosing recommendations 05chap2.doc Microsoft Word® Document MS Word® 97 SR-1 65KB 10 pages Contents: Chapter 2. Methodology: Overview; Technical Advisors; Search Strategy for the Identification of Articles; Determining Study Eligibility; Stages of Study Selection; Table 2. Reasons for study exclusion; Data Abstraction; Evaluation of Study Quality 06chap3.doc Microsoft Word® Document MS Word® 97 SR-1 278KB 47 pages Contents: Chapter 3. Results and Conclusions: Overview; Part I: Adult Patients with Chronic Renal Failure; Table 3. Overview of study quality and relevance: Results and conclusions, Part I; Table 4. Overview of outcomes reported in each study: Results and conclusions, Part I; Figure 1. Mean Mortality Rate as a Function of the Average Hematocrit Value; Table 5. Summary of results for Pickett, Theberge, Brown, et al., 1999; Part II: Pediatric Patients with Chronic Renal Failure; Table 6. Summary of observed effect on blood pressure in selected studies using epoetin to raise Hct over 30 percent in pediatric patients; Part III: Subpopulations of Interest (With or Without Chronic Renal Failure); Table 7. Overview of study quality: Results and conclusions, Part III; Table 8. Overview of outcomes reported in each study: Results and conclusions, Part III 07chap4.doc Microsoft Word® Document MS Word® 97 SR-1 33KB 2 pages Contents: Chapter 4. Future Research 08refs.doc Microsoft Word® Document MS Word® 97 SR-1 38KB 4 pages Contents: References 09etbls.doc Microsoft Word® Document MS Word® 97 SR-1 293KB 47 pages Contents: Acronyms and Abbreviations Used in Evidence Tables; Evidence Table 1. Randomized controlled clinical studies; Evidence Table 2. Nonrandomized controlled clinical trials; Evidence Table 3. Studies reporting cross-sectional analyses; Evidence Table 4. Mortality; Evidence Table 5. Quality of life; Evidence Table 6. Hospital utilization; Evidence Table 7. Use of red blood cell transfusion; Evidence Table 8. Cardiac health outcomes; Evidence Table 9. Cardiac intermediate health outcomes; Evidence Table 10. Exercise performance intermediate health outcomes; Evidence Table 11. Cognitive function intermediate health outcomes; Evidence Table 12. Sleep pattern intermediate health outcomes; Evidence Table 13. Nutritional status intermediate outcomes; Evidence Table 14. Treatment-related morbidity associated with normalization of hematocrit; Evidence Table 15. Randomized controlled clinical studies; Evidence Table 16. Studies reporting cross-sectional analyses; Evidence Table 17. Studies addressing impact of cardiovascular disease on relationship between hematocrit and outcomes; Evidence Table 18. Studies addressing impact of cerebrovascular disease on relationship between hematocrit and outcomes 10biblio.doc Microsoft Word® Document MS Word® 97 SR-1 328KB 51 pages Contents: Bibliography 11appa.doc Microsoft Word® Document MS Word® 97 SR-1 27KB 5 pages Contents: Appendix A. Technical Advisory Group, External Reviewers, and Medical Advisory Panel 12appb.doc Microsoft Word® Document MS Word® 97 SR-1 24KB 2 pages Contents: Appendix B. Data Abstraction Forms: Renal 13appc.doc Microsoft Word® Document MS Word® 97 SR-1 22KB 1 page Contents: Appendix C. Acronyms and Abbreviations __________________________________________________________________________________________________________
AHRQ Publication No. 01-E060
Current as of June 2001
Internet Citation:
Use of Epoetin for Anemia in Chronic Renal Failure. File Inventory, Evidence Report/Technology Assessment Number 29. AHRQ Publication No. 01-E016, June 2001. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/clinic/epcrfinv.htm
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