Prepared by:
Johns Hopkins Evidence-based Practice Center
Investigators
Kelly A. Gebo, M.D, M.P.H.
Mollie W. Jenckes, M.H.Sc., B.S.N.
Geetanjali Chander, M.D.
Michael S. Torbenson, M.D.
Khalil G. Ghanem, M.D.
H. Franklin Herlong, M.D.
Mark S. Sulkowski, M.D.
Samer S. El-Kamary, M.D.
Kirk A. Harris, B.A.
Otto C. Guedelhoefer
Eric B. Bass, M.D., M.P.H.
File Name Description Software Version File Size __________________________________________________________________________________________________________ 01front.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 38KB 9 pages Contents: Title Page, Preface, Acknowledgments, Structured Abstract, Table of Contents __________________________________________________________________________________________________________ 02summ.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 71KB 12 pages Contents: Summary: Overview, Reporting the Evidence, Role of Initial Liver Biopsy, Treatment Options, Screening for Hepatocellular Carcinoma, Methodology, Focus of Key Questions, Review Process, Findings, Future Research __________________________________________________________________________________________________________ 03chap1.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 18KB 4 pages Contents: Chapter 1.Introduction __________________________________________________________________________________________________________ 04chap2.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 55KB 10 pages Contents: Chapter 2.Methodology: Recruitment of Experts; Target Population; Identifying the Specific Questions; Key Questions; Causal Pathway; Literature Search Methods; Qualitative and Quantitative Data Abstraction; Article Review Process; Evidence Tables; Evidence Grades; Peer Review Process __________________________________________________________________________________________________________ 05fig1.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 21KB 1 page Contents: Figure 1: Causal pathway __________________________________________________________________________________________________________ 06chap3.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 274KB 43 pages Contents: Chapter 3.Results: Literature Search and Abstract Review; Article Review; Results of Key Questions: Q1b How well do the results of initial liver biopsy predict measures of disease progression and outcomes of treatment in patients with chronic hepatitis C, taking into consideration patient characteristics such as viral genotype? Q1e How well do biochemical blood tests and serologic measures of fibrosis predict the findings of liver biopsy in patients with chronic hepatitis C? Q2a What is the efficacy and safety of current treatment options for chronic hepatitis C in treatment-naive patients, including peginterferon plus ribavirin, peginterferon alone, interferon plus ribavirin, and interferon plus amantadine? Q2c What is the efficacy and safety of current interferon-based treatment options (including interferon alone) for chronic hepatitis C in selected subgroups of patients, especially those defined by the following characteristics: age less than or equal to 18 years, race/ethnicity, HCV genotype, presence or absence of cirrhosis, minimal versus decompensated liver disease, concurrent hepatitis B or HIV infection, non-response to initial interferon-based therapy, and relapse after initial interferon-based therapy? Q2d What are the long-term clinical outcomes (greater than or equal to 5 years) of current treatment options for chronic hepatitis C? Q3a What is the efficacy of using screening tests for hepatocellular carcinoma to improve clinical outcomes in patients with chronic hepatitis C? Q3b What are the sensitivity, specificity, and predictive values of tests that could be used to screen for hepatocellular carcinoma (especially resectable carcinoma) in patients with chronic hepatitis C? __________________________________________________________________________________________________________ 07fig2.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 53KB 1 page Contents: Figure 2: Sensitivity of HCC Detection by AFP Level __________________________________________________________________________________________________________ 08fig3.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 45KB 1 page Contents: Figure 3: Specificity by AFP Concentration __________________________________________________________________________________________________________ 09tbl1.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 14KB 2 pages Contents: Table 1: Evidence of Interaction Between Pre-Treatment Histology and Effect of Treatment on SVR __________________________________________________________________________________________________________ 10tbl2.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 46KB 5 pages Contents: Table 2: Evidence of Relationship Between HCV Genotype and Treatment Effect on SVR __________________________________________________________________________________________________________ 11chap4.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 57KB 12 pages Contents: Chapter 4. Conclusions: Key Findings; Limitations; Implications __________________________________________________________________________________________________________ 12chap5.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 14KB 3 pages Contents: Chapter 5. Future Research __________________________________________________________________________________________________________ 13refs.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 77KB 11 pages Contents: References __________________________________________________________________________________________________________ 14etbl1.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 84KB 9 pages Contents: Evidence Table 1: Overall summary of studies addressing the relation of initial liver biopsy results to outcomes of treatment for chronic hepatitis C __________________________________________________________________________________________________________ 15etbl2.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 160KB 19 pages Contents: Evidence Table 2: Characteristics of patients in studies addressing the use of liver biopsy to improve outcomes of treatment for chronic hepatitis C __________________________________________________________________________________________________________ 16etbl3.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 42KB 3 pages Contents: Evidence Table 3: Methodologic quality of studies addressing the relation of initial liver biopsy results to outcomes of treatment for chronic hepatitis C __________________________________________________________________________________________________________ 17etbl4.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 84KB 10 pages Contents: Evidence Table 4: Results of studies addressing the relation of initial liver biopsy results to outcomes of treatment for chronic hepatitis C __________________________________________________________________________________________________________ 18etbl5.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 126KB 15 pages Contents: Evidence Table 5: Overall summary of studies evaluating biochemical tests and serologic measures of fibrosis that may predict findings of liver biopsy __________________________________________________________________________________________________________ 19etbl6.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 161KB 23 pages Contents: Evidence Table 6: Characteristics of patients in studies evaluating biochemical tests and serologic measures of fibrosis that may predict findings of liver biopsy __________________________________________________________________________________________________________ 20etbl7.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 71KB 5 pages Contents: Evidence Table 7: Methodologic quality of studies evaluating biochemical tests and serologic measures of fibrosis that may predict findings of liver biopsy __________________________________________________________________________________________________________ 21etbl8.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 85KB 16 pages Contents: Evidence Table 8: Results of studies evaluating biochemical tests and serologic measures of fibrosis that may predict findings of liver biopsy __________________________________________________________________________________________________________ 22etbl9.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 54KB 7 pages Contents: Evidence Table 9: Overall summary of randomized controlled trials of current treatment options for chronic hepatitis C __________________________________________________________________________________________________________ 23etbl10.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 126KB 12 pages Contents: Evidence Table 10: Characteristics of patients in randomized controlled trials of current treatment options for chronic hepatitis C __________________________________________________________________________________________________________ 24etbl11.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 36KB 2 pages Contents: Evidence Table 11: Methodologic quality of randomized controlled trials of current treatment options for chronic hepatitis C __________________________________________________________________________________________________________ 25etbl12.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 90KB 7 pages Contents: Evidence Table 12: Results of randomized controlled trials of current treatment options for chronic hepatitis C __________________________________________________________________________________________________________ 26etbl13.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 124KB 14 pages Contents: Evidence Table 13: Overall summary of randomized controlled trials of current treatment options for selected sub-groups of patients with chronic hepatitis C __________________________________________________________________________________________________________ 27etbl14.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 199KB 25 pages Contents: Evidence Table 14: Characteristics of patients in randomized controlled trials of current treatment options for selected sub-groups of patients with chronic hepatitis C __________________________________________________________________________________________________________ 28etbl15.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 50KB 4 pages Contents: Evidence Table 15: Methodologic quality of randomized controlled trials of current treatment options for selected sub-groups of patients with chronic hepatitis C __________________________________________________________________________________________________________ 29etbl16.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 146KB 12 pages Contents: Evidence Table 16: Results of randomized controlled trials of current treatment options for selected sub-groups of patients with chronic hepatitis C __________________________________________________________________________________________________________ 30etbl17.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 102KB 10 pages Contents: Evidence Table 17: Overall summary of long term outcomes of chronic hepatitis C __________________________________________________________________________________________________________ 31etbl18.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 137KB 19 pages Contents: Evidence Table 18: Characteristics of patients in studies evaluating long-term outcomes of chronic hepatitis C __________________________________________________________________________________________________________ 32etbl19.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 51KB 4 pages Contents: Evidence Table 19: Methodologic quality of studies evaluating long term outcomes of chronic hepatitis C __________________________________________________________________________________________________________ 33etbl20.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 128KB 11 pages Contents: Evidence Table 20: Results of studies evaluating long-term outcomes of chronic hepatitis C __________________________________________________________________________________________________________ 34etbl21.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 16KB 1 page Contents: Evidence Table 21: Overall summary of study addressing efficacy of screening tests for hepatocellular carcinoma to improve outcomes of chronic hepatitis C __________________________________________________________________________________________________________ 35etbl22.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 19KB 1 page Contents: Evidence Table 22: Characteristics of patients in study addressing efficacy of screening tests for hepatocellular carcinoma to improve outcomes of chronic hepatitis C __________________________________________________________________________________________________________ 36etbl23.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 18KB 1 page Contents: Evidence Table 23: Methodologic quality of study containing efficacy of screening tests for hepatocellular carcinoma to improve outcomes of chronic hepatitis C __________________________________________________________________________________________________________ 37etbl24.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 8KB 1 page Contents: Evidence Table 24: Results of study evaluating efficacy of screening tests for hepatocellular carcinoma to improve outcomes of chronic hepatitis C __________________________________________________________________________________________________________ 38etbl25.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 63KB 6 pages Contents: Evidence Table 25: Overall summary of studies addressing performance characteristics of screening tests for detecting hepatocellular carcinoma in patients with chronic hepatitis C __________________________________________________________________________________________________________ 39etbl26.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 83KB 12 pages Contents: Evidence Table 26: Characteristics of patients in studies addressing performance characteristics of screening tests for detecting hepatocellular carcinoma in patients with chronic hepatitis C __________________________________________________________________________________________________________ 40etbl27.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 43KB 4 pages Contents: Evidence Table 27: Methodologic quality of studies addressing performance characteristics of screening tests for detecting hepatocellular carcinoma in patients with chronic hepatitis C __________________________________________________________________________________________________________ 41etbl28.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 73KB 8 pages Contents: Evidence Table 28: Results of study addressing performance characteristics of screening tests for detecting hepatocellular carcinoma in patients with chronic hepatitis C __________________________________________________________________________________________________________ 42biblio.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 218KB 33 pages Contents: Bibliography __________________________________________________________________________________________________________ 43appa.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 29KB 2 pages Contents: Appendix A: Reviewers __________________________________________________________________________________________________________ 44appb.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 6KB 1 page Contents: Appendix B: Priority Journals for Handsearching __________________________________________________________________________________________________________ 45appc.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 17KB 2 pages Contents: Appendix C: Literature Search Strategy __________________________________________________________________________________________________________ 46appd.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 13KB 1 page Contents: Appendix D: Abstract Review Form __________________________________________________________________________________________________________ 47appe.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 66KB 8 pages Contents: Appendix E: Study Quality Review Form __________________________________________________________________________________________________________ 48acro.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 49KB 3 pages Contents: Acronyms and Abbreviations __________________________________________________________________________________________________________
AHRQ Publication No. 02-E030
Current as of July 2002
Internet Citation:
Management of Chronic Hepatitis C. File Inventory, Evidence Report/Technology Assessment Number 60. AHRQ Publication No. 02-E030, July 2002. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/clinic/hepcinv.htm
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