Prepared by:
Tufts New England Medical Center EPC
Boston, MA
Principal Investigator
Cynthia Cole, M.D., M.P.H.
Investigators
Geoffrey Binney, M.D., M.P.H.
Patricia Casey, R.N.C., M.S., N.N.P.
John Fiascone, M.D.
James Hagadorn, M.D.
Chiwan Kim, M.D.
EPC Staff
Joseph Lau, M.D., Director
Chenchen Wang, M.D., M.Sc., Project Leader
Deirdre DeVine, M.Litt., Project Manager
Kimberly Miller, B.A., Research Assistant
File Name Description Software Version File Size ________________________________________________________________________________________________ 01front1.doc Microsoft Word® Document MS Word® 2002 165KB 13 pages Contents: Volume 1 Title Page, Preface, Acknowledgments, Structured Abstract, Table of Contents ________________________________________________________________________________________________ 02summ.doc Microsoft Word® Document MS Word® 2002 76KB 11 pages Contents: Summary: Overview, Reporting the Evidence, Findings, Future Research ________________________________________________________________________________________________ 03chap1.doc Microsoft Word® Document MS Word® 2002 62KB 6 pages Contents: Chapter 1. Introduction: Definition of Disability; Definition of Prematurity; The Problem of Prematurity; Table A. Live birth distribution organized by birth weight and gestation in the United States in the year 2000; Table B. Mortality and Morbidity of Premature Infants by Birth Weight Born in NICHD Neonatal Research Network Between January 1, 1993 and December 31, 1994; Factors Associated with Disability in VLBW Infants ________________________________________________________________________________________________ 04chap2.doc Microsoft Word® Document MS Word® 2002 141KB 10 pages Contents: Chapter 2. Methods: Key Questions Addressed by the Evidence Report; Literature Search Strategies; Study Selection; Table C. Inclusion/exclusion criteria; Outcomes and Predictors Considered in this Evidence Report; Table D. List of predictors and outcomes; Reporting the Evidence; Table E. Evidence tables created in this report; Summarizing the Evidence of Individual Studies ________________________________________________________________________________________________ 05chap3a.doc Microsoft Word® Document MS Word® 2002 599KB 48 pages Contents: Chapter 3. Results: Evidence that VLBW With or Without Other Conditions is Associated With Cerebral Palsy (CP) and Neurologic Disability; Table 1.1a. Association of Cerebral Palsy with VLBW/Prematurity; Table 1.1b. Association of Cerebral Palsy with LBW / Prematurity; Table 1.2a. Association of Cerebral Palsy by Degree of Immaturity; Table 1.3a. Association of CP and neurologic abnormalities in VLBW with CNS injury; Table 1.3b. Association of CP and neurologic abnormalities with antenatal risk factors in VLBW infants; Table 1.3c. Association of CP and neurologic abnormalities in VLBW with BPD and BPD and postnatal systemic glucocorticoid therapy; Table 1.3d. Association of CP and neurologic abnormalities in VLBW infants parenting / psychosocial risk factors; Table 1.3e. Association of CP and neurologic abnormalities in VLBW plus other factors; Evidence That VLBW With Or Without Other Conditions Is Associated With Abnormal Cognitive Development And MR; Table 2.1. Representative ability test scores defining significantly delayed or deficient cognitive development/mental retardation; Table 2.2. Incidence of Mental Retardation in VLBW / ELBW Infants; Table 2.3. Changes in incidence of MR with time in LBW infants; Table 2.4. Association of Mental Retardation / Disability to Independent Risk Factors in LBW infants; Table 2.5. Association of Mental Retardation / Disability with other Risk Factors in LBW infants; Evidence That VLBW Is Associated With Disabilities Of Speech/Language Delay, Hearing Loss, Behavioral Disorders, And Learning Disabilities; ________________________________________________________________________________________________ 06chap3b.doc Microsoft Word® Document MS Word® 2002 677KB 53 pages Contents: Chapter 3. Results: Evidence That VLBW Is Associated With Disabilities Of Speech/Language Delay, Hearing Loss, Behavioral Disorders, And Learning Disabilities (continued); Table 3.1. Association of LBW to Speech and Language Disorders; Table 3.2. Association of VLBW with Hearing Loss; Table 3.3. Association of LBW to Behavior Outcomes; Table 3.4. Association of LBW to Learning Disability and School Performance; Evidence That VLBW With Or Without Other Conditions Is Associated With Visual Disability; Table 4.1. Association of VLBW/Prematurity with Ophthalmology Outcomes; Table 4.2a. Visual disability related to increasing severity of ROP in VLBW infants; Table 4.2b. Proportion of eyes with unfavorable visual function; Table 4.3. Unfavorable functional outcome in eyes with threshold ROP by randomized treatment assignment (cryotherapy vs. no cryotherapy) during 1, 3.5, 5.5, and 10-year follow-up; Table 4.4. Visual disability related to severe (threshold) ROP; Table 4.5. Evidence that VLBW infants with CNS abnormality have visual disability (with no or mild ROP); Table 4.6. VLBW and/or ROP and/or CNS injury are positively associated with refractive error (myopia) and ocular motility (strabismus); Table 4.7. Abnormal visual function due to fixation instability (nystagmus and strabismus) in VLBW infants; Table 4.8. Association between VLBW plus bronchopulmonary dysplasia (BPD) and systemic glucocorticosteroid therapy for bronchopulmonary dysplasia with visual disability; Evidence That VLBW With Or Without Other Conditions Is Associated With Pulmonary Disability; Table 5.1. Percent of infants with BPD* in Relation to Birth Weight in the Vermont Oxford Neonatal Network; Table 5.2a. VLBW with BPD is associated with long-term pulmonary morbidity and disability by 1-2 year of follow-up; Table 5.2b. VLBW with BPD is associated with long-term pulmonary disability by 3 years of follow-up; Table 5.2c. VLBW with BPD is associated with long-term pulmonary disability by 6-12 year of follow-up; Table 5.2d. VLBW with BPD is associated with long-term pulmonary disability by 12-16 year of follow-up; Table 5.3. Association of VLBW/Prematurity with asthma or hyper-reactive airway disease; Table 5.4. Association of VLBW/Prematurity with rehospitalization for respiratory illness: pulmonary outcomes; Evidence That VLBW With Or Without Other Conditions Is Associated With Growth Impairment; Table 6.1. Association of VLBW/Prematurity with Growth Impairment; ________________________________________________________________________________________________ 07chap3c.doc Microsoft Word® Document MS Word® 2002 115KB 5 pages Contents: Contents: Chapter 3. Results: Evidence That VLBW With Or Without Other Conditions Is Associated With Growth Impairment (continued); Table 6.2. Association of VLBW plus BPD with Growth impairment; Table 6.3. Association of VLBW plus antenatal glucocorticoid exposure growth impairment; Table 6.4. Association of VLBW plus necrotizing enterocolitis exposure growth impairment; Table 6.5. Association of VLBW plus postnatal nutrition with growth impairment; Table 6.6. Association of LBW/Prematurity to Growth Delay ________________________________________________________________________________________________ 08chap4.doc Microsoft Word® Document MS Word® 2002 39KB 5 pages Contents: Chapter 4. Conclusions: Overall; Neurodevelopmental Disabilities; Speech and Language; Visual Disability; Pulmonary Disability; Poor Growth ________________________________________________________________________________________________ 09chap5.doc Microsoft Word® Document MS Word® 2002 32KB 3 pages Contents: Chapter 5. Future Research: Evaluation of the Application Process of SSA VLBW Disability Criteria; Determine the Appropriateness of the New VLBW Disability Criteria Proposed by SSA Based on the Evidence of this Report; Proposal to Improve the Evidence of Predictors and Predictive Models; Feasibility of Future Research Proposals ________________________________________________________________________________________________ 10refs.doc Microsoft Word® Document MS Word® 2002 90KB 12 pages Contents: References/Bibliography ________________________________________________________________________________________________ 11appa.doc Microsoft Word® Document MS Word® 2002 110KB 7 pages Contents: Appendix A. Search Strategies ________________________________________________________________________________________________ 12appb.doc Microsoft Word® Document MS Word® 2002 169KB 11 pages Contents: Appendix B. Data Abstraction Form ________________________________________________________________________________________________ 13appc.doc Microsoft Word® Document MS Word® 2002 50KB 2 pages Contents: Appendix C. Acronyms and Abbreviations ________________________________________________________________________________________________ 14appd.doc Microsoft Word® Document MS Word® 2002 36KB 3 pages Contents: Appendix D. Acknowledgements ________________________________________________________________________________________________ 15front2.doc Microsoft Word® Document MS Word® 2002 36KB 4 pages Contents: Volume 2 Title Page, Table of Contents ________________________________________________________________________________________________ 16etbl1.doc Microsoft Word® Document MS Word® 2002 722KB 94 pages Contents: Evidence Table 1. Studies Evaluating Association of LBW and Multiple Outcomes: CNS, Eye, Lung, Growth, etc ________________________________________________________________________________________________ 17etbl2.doc Microsoft Word® Document MS Word® 2002 82KB 9 pages Contents: Evidence Table 2. Randomized Controlled Trials for LBW Infants and Multiple Outcomes: CNS, Eye, Lung, Growth ________________________________________________________________________________________________ 18etbl3.doc Microsoft Word® Document MS Word® 2002 808KB 95 pages Contents: Evidence Table 3. Studies Evaluating Association of LBW and Cerebral Palsy and Neurological Outcomes ________________________________________________________________________________________________ 19etbl4.doc Microsoft Word® Document MS Word® 2002 106KB 14 pages Contents: Evidence Table 4. Studies Evaluating Treatment Effects of LBW and Cerebral Palsy and Neurological Outcomes ________________________________________________________________________________________________ 20etbl5a.doc Microsoft Word® Document MS Word® 2002 115KB 17 pages Contents: Evidence Table 5A. Studies Evaluating Association of LBW to Speech and Language Disorders ________________________________________________________________________________________________ 21etbl5b.doc Microsoft Word® Document MS Word® 2002 264KB 37 pages Contents: Evidence Table 5B. Studies Evaluating Association of LBW to Audiology Outcomes ________________________________________________________________________________________________ 22etbl6a.doc Microsoft Word® Document MS Word® 2002 103KB 12 pages Contents: Evidence Table 6A. Studies Evaluating Association of LBW to Behavioral Disorders ________________________________________________________________________________________________ 23etbl6b.doc Microsoft Word® Document MS Word® 2002 61KB 5 pages Contents: Evidence Table 6B. Studies Evaluating Association of LBW to School Performance and Learning Disabilities ________________________________________________________________________________________________ 24etbl7.doc Microsoft Word® Document MS Word® 2002 106KB 11 pages Contents: Evidence Table 7. Studies Evaluating Association of LBW to Ophthalmologic Outcomes ________________________________________________________________________________________________ 25etbl8.doc Microsoft Word® Document MS Word® 2002 143KB 12 pages Contents: Evidence Table 8. Studies of Treatment Effects for LBW Infants With Retinopathy of Prematurity (ROP) ________________________________________________________________________________________________ 26etbl9.doc Microsoft Word® Document MS Word® 2002 189KB 20 pages Contents: Evidence Table 9. Studies Evaluating Association of LBW and Pulmonary Outcomes ________________________________________________________________________________________________ 27etbl10.doc Microsoft Word® Document MS Word® 2002 155KB 15 pages Contents: Evidence Table 10. Studies Evaluating Association of LBW and Bone and Growth Outcomes ________________________________________________________________________________________________ 28etbl11.doc Microsoft Word® Document MS Word® 2002 50KB 4 pages Contents: Evidence Table 11. Randomized Controlled Trials in LBW Neonates for Growth Outcomes ________________________________________________________________________________________________ 29etbl12.doc Microsoft Word® Document MS Word® 2002 54KB 1 page Contents: Evidence Table 12. Studies Evaluating Association of LBW and Nutritional Outcomes ________________________________________________________________________________________________ 30etbl13.doc Microsoft Word® Document MS Word® 2002 90KB 8 pages Contents: Evidence Table 13. Studies Evaluating Association of LBW and Other Outcomes ________________________________________________________________________________________________
AHRQ Publication No. 03-E010
Current as of December 2002
Internet Citation:
Criteria for Determining Disability in Infants and Children: Low Birth Weight. File Inventory, Evidence Report/Technology Assessment Number 70. AHRQ Publication No. 03-E010, December 2002. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/clinic/lbwinv.htm
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