Prepared by:
MetaWorks, Inc., Evidence-based Practice Center
Medford, MA
Investigators
Cindy B. Levine, M.D.
Kyle R. Fahrbach, Ph.D.
Andrew D. Siderowf, M.D.
Rhonda P. Estok, R.N., B.S.N.
Veronica M. Ludensky, B.A.
Susan D. Ross, M.D., FRCPC
File Name Description Software Version File Size ________________________________________________________________________________________________ 01front.doc Microsoft Word® Document MS Word® 2002 90KB 10 pages Contents: Title Page, Preface, Structured Abstract, Table of Contents 02summ.doc Microsoft Word® Document MS Word® 2002 53KB 7 pages Contents: Summary: Overview, Reporting the Evidence, Methodology, Findings, Future Research 03chap1.doc Microsoft Word® Document MS Word® 2002 81KB 13 pages Contents: Chapter 1. Introduction: Etiology, Clinical Features, Diagnosis, Assessment of PD Severity, Treatment, Objectives, Original Key Questions, Revised Key Questions 04chap2.doc Microsoft Word® Document MS Word® 2002 75KB 11 pages Contents: Chapter 2. Methodology: Literature Search, Exclusion Criteria, Inclusion Criteria, Linked Studies, Rating the Evidence, Data Extraction, Database Development, Statistical Methods, Role of Consultants, Peer Review 05fig1.ppt Microsoft PowerPoint® Presentation MS PowerPoint® 2002 89KB 1 page Contents: Figure 1. MetaWorks Systematic Review Process Diagram 06chap3.doc Microsoft Word® Document MS Word® 2002 203KB 30 pages Contents: Chapter 3. Results: Searches, Studies, Diagnosis, Pharmacological Treatment of PD, Surgical Treatment of PD, Psychiatric Treatment, Ancillary Treatment, Genetics 07fig2.ppt Microsoft PowerPoint® Presentation MS PowerPoint® 2002 35KB 1 page Contents: Figure 2. Study Attrition 08fg3-11.doc Microsoft Word® Document MS Word® 2002 278KB 9 pages Contents: Figure 3. Dopamine Agonist + L-Dopa vs. L-Dopa, Figure 4. Selegiline + L-Dopa vs. L-Dopa, Figure 5. COMT Inhibitor + L-Dopa vs. L-Dopa, Figure 6. Surgery: Pallidotomy (Off Scores), Figure 7. Surgery: Pallidotomy (On Scores), Figure 8. Surgery: Deep Brain Stimulation (Off Scores), Figure 9. Surgery: Deep Brain Stimulation (On Scores), Figure 10. Surgery: Fetal Cell Transplant (Off Scores), Figure 11. Surgery: Fetal Cell Transplant (On Scores) 09chap4.doc Microsoft Word® Document MS Word® 2002 38KB 4 pages Contents: Chapter 4. Answers to Revised Key Questions 10chap5.doc Microsoft Word® Document MS Word® 2002 24KB 1 page Contents: Chapter 5. Strengths and Limitations of the Evidence Base 11chap6.doc Microsoft Word® Document MS Word® 2002 30KB 3 pages Contents: Chapter 6. Recommendations for Future Research 12chap7.doc Microsoft Word® Document MS Word® 2002 20KB 1 page Contents: Chapter 7. Harnessing the Available Evidence 13refs.doc Microsoft Word® Document MS Word® 2002 152KB 16 pages Contents: References 14evtbls.xls Microsoft Excel® Worksheet MS Excel® 2002 90KB 16 pages Contents: Evidence Tables: Evidence Table 1. Summary of Rejected Studies, Evidence Table 2. Study Level Characteristics, Evidence Table 3. Overall Treatment Level Characteristics, Evidence Table 4. Treatment Level Characteristics of Diagnostic Studies, Evidence Table 5. Treatment Level Characteristics of Pharmacological Studies, Evidence Table 6. Statistical Analysis: Dopamine Agonists with L-Dopa vs. L-Dopa Alone, Evidence Table 7. Statistical Analysis: Selegiline with L-Dopa vs. L-Dopa Alone, Evidence Table 8. Statistical Analysis: COMT Inhibitors with L-Dopa vs. L-Dopa Alone, Evidence Table 9. Pharmacological Studies: Adverse Events, Evidence Table 10. Pharmacological Studies: Neurological and Psychiatric Adverse Events, Evidence Table 11. Treatment Level Characteristics of Surgical Studies, Evidence Table 12. Statistical Analysis: Pallidotomy, Evidence Table 13. Statistical Analysis: Deep Brain Stimulation, Evidence Table 14. Statistical Analysis: Tissue Transplantation, Evidence Table 15. Surgical Studies: Adverse Events, Evidence Table 16. Treatment Level Characteristics of Ancillary Studies 15biblio.doc Microsoft Word® Document MS Word® 2002 167KB 16 pages Contents: Bibliography 16appa.doc Microsoft Word® Document MS Word® 2002 212KB 41 pages Contents: Appendix A. Major Parkinson's Disease Rating Scales 17appb.doc Microsoft Word® Document MS Word® 2002 159KB 23 pages Contents: Appendix B. Work Plan 18appc.doc Microsoft Word® Document MS Word® 2002 55KB 2 pages Contents: Appendix C. Topic Assessment and Refinement 19appd-1.doc Microsoft Word® Document MS Word® 2002 20KB 1 page Contents: Appendix D. Causal Pathways: Diagnosis and Treatment of Parkinson's Disease: Cover page 20appd-2.doc Microsoft Word® Document MS Word® 2002 25KB 2 pages Contents: Appendix D. Causal Pathways: Diagnosis and Treatment of Parkinson's Disease: Causal Pathway: Diagnosis of Parkinson's Disease Legends 21appd-3.ppt Microsoft PowerPoint® Presentation MS PowerPoint® 2002 35KB 1 page Contents: Appendix D. Causal Pathways: Diagnosis and Treatment of Parkinson's Disease: Causal Pathway: Diagnosis of Parkinson's Disease 22appd-4.doc Microsoft Word® Document MS Word® 2002 24KB 1 page Contents: Appendix D. Causal Pathways: Diagnosis and Treatment of Parkinson's Disease: Causal Pathway: Treatment of Parkinson's Disease Legends 23appd-5.ppt Microsoft PowerPoint® Presentation MS PowerPoint® 2002 27KB 1 page Contents: Appendix D. Causal Pathways: Diagnosis and Treatment of Parkinson's Disease: Causal Pathway: Treatment of Parkinson's Disease 24appe-1.doc Microsoft Word® Document MS Word® 2002 20KB 1 page Contents: Appendix E. Screening Sheets and Data Extraction Forms 25appe-2.xls Microsoft Excel® Worksheet MS Excel® 2002 34KB 3 pages Contents: Appendix E. Screening Sheets and Data Extraction Forms (continued) 26appe-3.doc Microsoft Word® Document MS Word® 2002 26KB 1 page Contents: Appendix E. Screening Sheets and Data Extraction Forms (continued) 27appe-4.doc Microsoft Word® Document MS Word® 2002 27KB 1 page Contents: Appendix E. Screening Sheets and Data Extraction Forms (continued) 28appe-5.doc Microsoft Word® Document MS Word® 2002 28KB 1 page Contents: Appendix E. Screening Sheets and Data Extraction Forms (continued) 29appe-6.xls Microsoft Excel® Worksheet MS Excel® 2002 51KB 4 pages Contents: Appendix E. Screening Sheets and Data Extraction Forms (continued) 30appe-7.xls Microsoft Excel® Worksheet MS Excel® 2002 57KB 5 pages Contents: Appendix E. Screening Sheets and Data Extraction Forms (continued) 31appe-8.xls Microsoft Excel® Worksheet MS Excel® 2002 54KB 5 pages Contents: Appendix E. Screening Sheets and Data Extraction Forms (continued) 32appe-9.xls Microsoft Excel® Worksheet MS Excel® 2002 41KB 4 pages Contents: Appendix E. Screening Sheets and Data Extraction Forms (continued) 33appf.doc Microsoft Word® Document MS Word® 2002 63KB 3 pages Contents: Appendix F. Statistical Reference 34appg-1.doc Microsoft Word® Document MS Word® 2002 20KB 1 page Contents: Appendix G. Technical Experts and Peer Reviewers 35appg-2.xls Microsoft Excel® Worksheet MS Excel® 2002 20KB 2 pages Contents: Appendix G. Technical Experts and Peer Reviewers (continued) 36appg-3.xls Microsoft Excel® Worksheet MS Excel® 2002 15KB 1 page Contents: Appendix G. Technical Experts and Peer Reviewers (continued) 37appg-4.doc Microsoft Word® Document MS Word® 2002 48KB 2 pages Contents: Appendix G. Technical Experts and Peer Reviewers (continued) 38apph.doc Microsoft Word® Document MS Word® 2002 158KB 17 pages Contents: Appendix H. Accepted Studies Log 39appi.doc Microsoft Word® Document MS Word® 2002 263KB 29 pages Contents: Appendix I. Rejected Studies Log 40appj.doc Microsoft Word® Document MS Word® 2002 44KB 6 pages Contents: Appendix J. Studies of Interest Excluded from Database 41appk.doc Microsoft Word® Document MS Word® 2002 35KB 4 pages Contents: Appendix K. Acronyms in This Report ________________________________________________________________________________________________
AHRQ Publication No. 03-E040
Current as of June 2003
Internet Citation:
Diagnosis and Treatment of Parkinson's Disease: A Systematic Review of the Literature. File Inventory, Evidence Report/Technology Assessment Number 57. AHRQ Publication No. 03-E040, June 2003. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/clinic/parkinv.htm
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