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Method of Altering Sphingolipid Metabolism and Detecting Fumonisin Ingestion and Contamination
Patent Number: 5518879
Docket Number: 30593
Serial Number: 8042147
Date Patented: 05/21/1996
Agency:
Agricultural Research Service
Issued:
March 21, 1996
Abstract:
Fusarium moniliforme (Sheldon) is one of the most common fungi
on maize and other grains and agricultural commodities. It
has been shown to be toxic and carcinogenic and consumption
of contaminated maize has been correlated with esophageal
cancer, equine leucoencephalomalacia, porcine pulmonary
edema, liver tumors in rats, Neimann-Picks syndrome and Tay-
Sachs disease. Several mycotoxins, termed fumonisins have
been isolated from F. Moniliforme and are believed to be
responsible for toxic effects. The invention relates to a
method of detecting the presence of fumonisin or a fumonisin
analog contamination in a sample of food, to a method of
detecting fumonisin consumption in animals, and a method of
treating illnesses caused by fumonisin consumption.
Inventors:
| Alfred H. Merrill Jr. | Elaine T. Wang / Ronald T. Riley |
| Emory University, Biochemistry | (Same as first inventor) |
| 4113 Rollins Research Building |
| Atlanta, GA 30322 |
| (404) 727-5978 |
Industry Keywords:
sphingosine metabolism, sphingolipid, corn, wheat
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