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Leader-Proteinase Deleted Foot-and-Mouth Disease Viruses and Their Use as Vaccines
Patent Number: 5824316
Docket Number: 795
Serial Number: 8653037
Date Patented: 10/20/1998
Agricultural Research Service
Date Issued:
October 20, 1998
Abstract:
The invention is a genetically engineered
virus that can be formulated into an effective vaccine for preventing
foot-and-mouth disease in cattle and swine. The DNA sequence containing the
genetic information for a virus protein is removed, allowing the scientist to
produce a weakened version of the virus that can be used as a vaccine. This
method produces a deleted virus which is able to assemble and grow in cells in
culture. The genetically engineered foot-and-mouth
disease virus induces an FMDV-specific antibody response in inoculated animals
that protects them against disease. The invention can be used to combat
foot-and-mouth disease which causes painful blisters on the tongue, nose or
snout, and feet of livestock, which results in severe economic losses.
Inventors:
Marvin J. Grubman Foot and Mouth Disease Research Greenport, NY 11944-0848 (631) 323-3329 / Fax: (631) 323-2798 E-mail: mgrubman@piadc.ars.usda.gov | Peter W. Mason (Same as first inventor) (631) 323-3177 / Fax: (631) 323-2798 E-mail: pwmason@piadc.ars.usda.gov | Maria Elisa Piccone (Formerly with ARS) | Elizabeth Rieder (Formerly with
ARS) |
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