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Method to Produce Granulocyte Colony Stimulating Factor from Immortalized Avian T-Lymphocytes and Method to Produce Immortilized Cells
Patent Number: 5691200
Docket Number: 16895
Serial Number: 8675749
Date Patented: 11/25/1997
Agency:
Agricultural Research Service
Issued:
November 25, 1997
Abstract:
The invention involves a method to control a variety of pathogenic organisms such
as Salmonella in poultry. The invention produces immortalized poultry T-cell lines
which secrete lymphokines that enhance immunity. These cell lines may be
produced from T cells recovered from fowl which have been hyperimmunized in
vivo. These activated T cells are first exposed in vitro to a mitogen effective for
secondary stimulation, and then virally transformed to produce an immortal cell
line. When cultured in vitro, the cell lines produce and secrete immune
lymphokines which may be administered by injection to poultry to increase
resistance to infections.
Inventors:
| Michael H. Kogut | Rita B. Moyes |
| Food Animal Protection Research Lab | (Same address as above) |
| College Station, Texas 77845 | (409) 260-9374 |
| (409) 260-9221/(409) 260-9332 (fax) |
| Larry H. Stanker | Billy M. Hargis |
| (Same address as above) | (Same address as above) |
| (409) 260-9306 | (409) 845-8989/(409) 845-9972 (fax) |
| John R. DeLoach (former ARS) |
Industry Keywords:
cell lines, hybridomas, monoclonal antibodies, pharmaceutical, enzymes,
proteins, vaccine, biotechnology, animal health, veterinary, poultry
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