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PRODUCTION OF SPECIFIC ANTISERA USING TRANSFECTED MOLECULES; E.G., MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) MOLECULES IN CHICKENS
Patent Number: 6075125
Docket Number: 6496
Serial Number: 8890719
Date Patented: 06/13/2000
Patent Number: 6075125
Docket Number: 6496
Serial Number: 8890719
Date Patented: 06/13/2000
Agricultural Research Service
Date Issued:
June 13, 2000
Abstract:
The invention involves a way to determine the presence of a specific protein in chickens that indicates resistance or
susceptibility to viral diseases. This is achieved by inserting a recombinant DNA molecule into a host chicken cell,
directing the cell to express a heterologous or foreign chicken major histocompatibility complex (MHC) protein.
Because of its strong association with disease resistance, the determination of the MHC haplotype is of great interest
to poultry breeders seeking to improve flocks. The invention can be used as an immunogen to produce a protein-specific antisera. The antisera is produced in cell culture and can be used to determine the BF haplotype of any chicken.
Inventors:
Larry D. Bacon
Avian Disease & Oncology Laboratory
East Lansing, MI 48824
(517) 337-6828 / Fax: (517) 337-6776 |
Henry D. Hunt
(same address as first inventor) |
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Janet E. Fulton
Hy-Line International
P.O. Box 310, 1915 Sugar Grove
Dallas Center, IA 50063 |
Industry Keywords:
biotechnology, cell culture, cell lines, hybridomas, monoclonal antibodies, genetic modification, organisms, nucleic
acids, genes, DNA/RNA, chickens, antisera, immunogen
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