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Species-Specific Genetic Identification of Mycobacterium Paratuberculosis
Technology Description:
The invention is a way to specifically identify the bacterium Mycobacterium paratuberculosis for early detection of Johne’s disease in cattle, which annually causes severe economic losses. The bacterium has also been isolated from humans and has possible implications for patients suffering from Crohn’s disease. The invention uses a gene isolated from M. paratuberculosis for development of probes and primers that are species-specific. The gene, known as hspX, assists in providing a sensitive, specific and rapid diagnostic tool for positively identifying M. paratuberculosis. The target sequences of the gene lend themselves to the development of species-specific DNA or RNA-based diagnostic assays. The gene sequence in M. paratuberculosis species also suggests that it encodes a protein which has the ability to elicit antibody production in animals.
Reference:
Please refer to Patent Number 5,985,576, which issued on November 16, 1999.
Inventors:
Judith R. Stabel |
Jay L. E. Ellingson Marshfield Clinic National Farm Medical Center 1000 N. Oak Avenue Marshfield, WI 54449 |
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