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SPECIES-SPECIFIC GENETIC IDENTIFICATION OF MYCOBACTERIUM PARATUBERCULOSIS
See also: US Patent Office Full Record

Patent Number: 5985576
Docket Number: 22997
Serial Number: 9108051
Date Patented: 11/16/1999
Patent Number: 5985576
Docket Number: 22997
Serial Number: 9108051
Date Patented: 11/16/1999

Agricultural Research Service

Issued:
November 16, 1999

Abstract:
The invention is a way to specifically identify the bacterium Mycobacterium paratuberculosis for early detection of Johne's disease in cattle, which annually causes severe economic losses. The bacterium has also been isolated from humans and has possible implications for patients suffering from Crohn's disease. The invention uses a gene isolated from M. paratuberculosis for development of probes and primers that are species-specific. The gene, known as hspX, assists in providing a sensitive, specific and rapid diagnostic tool for positively identifying M. paratuberculosis. The target sequences of the gene lend themselves to the development of species-specific DNA or RNA-based diagnostic assays. The gene sequence in M. paratuberculosis species also suggests that it encodes a protein which has the ability to elicit antibody production in animals.

Inventors:
Jay L. E. Ellingson
Zoonotic Diseases Research
Ames, Iowa 50010
(515) 239-8325 / Fax: (515) 239-8458
Judith R. Stabel
(Same address as first inventor)

Industry Keywords:
biotechnology, nucleic acids, genes, DNA/RNA, probes, primers, veterninary, Jone's disease, Crohn's disease, genetic engineering, diagnostic, Mycobacterium, assays.

Species-Specific Genetic Identification of Mycobacterium Paratuberculosis

Technology Description:

The invention is a way to specifically identify the bacterium Mycobacterium paratuberculosis for early detection of Johne’s disease in cattle, which annually causes severe economic losses. The bacterium has also been isolated from humans and has possible implications for patients suffering from Crohn’s disease. The invention uses a gene isolated from M. paratuberculosis for development of probes and primers that are species-specific. The gene, known as hspX, assists in providing a sensitive, specific and rapid diagnostic tool for positively identifying M. paratuberculosis. The target sequences of the gene lend themselves to the development of species-specific DNA or RNA-based diagnostic assays. The gene sequence in M. paratuberculosis species also suggests that it encodes a protein which has the ability to elicit antibody production in animals.

Reference:

Please refer to Patent Number 5,985,576, which issued on November 16, 1999.

Inventors:

Judith R. Stabel
Bacterial Diseases of Livestock Research Unit
Ames, IA  50010
(515) 663-7304 / Fax: (515) 663-7458
jstabel@nadc.ars.usda.gov



Jay L. E. Ellingson
Marshfield Clinic
National Farm Medical Center
1000 N. Oak Avenue
Marshfield, WI  54449



 

 
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