Inhibition of Cytokine Production by Polymethoxylated Flavones

Technology Description:

The invention relates to the treatment of any disease or disorder mediated by cytokines (e.g., tumor necrosis alpha). Examples of such diseases are septic shock, cancer, cachexia, chronic rheumatism, ulcerative colitis, Crohn's disease, and many other diseases and disorders mediated by cytokines. The invention also relates to a method of inhibiting the production of cytokines, particularly inhibiting the production of tumor necrosis factor alpha in a mammal, including a human. This involves administering an effective amount of a polymethoxylated flavone.

Reference:

Please refer to Patent Number 6,184,246, which issued February 6, 2001.

Inventors:

John A. Manthey USDA, ARS, SAA, QICSP Winter Haven, FL 33833 (863) 293-4133 / Fax: (863) 299-8678 jmanthey@citrus.usda.gov	Carl L. Manthey 1508 Norwood House Road Exton, PA 19335
Antonio Montanari 4139 Windmere Lane Charlotte, NC 28211 (704) 367-9591