NIDA Research Monograph, Number 173 [Printed in 1997]
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Table of Contents
Introduction-----1
Rao S. Rapaka, Nora Chiang, and Billy R. Martin
The Potential Role of the Cytochrome P-450
2D6 Pharmacogenetic Polymorphism in Drug Abuse-----6
Edward M. Sellers, S. Victoria Otton, and Rachel F. Tyndale
Human Liver Cocaine Carboxylesterases-----27
William F. Bosron, Robert A. Dean, Monica R. Brzezinski, and Evgenia
V. Pindel
Effects of Ethanol on Cocaine Metabolism and
Disposition in the Rat-----35
Robert A. Dean, William F. Bosron, Frederick M. Zachman, Jing Zhang,
and Monica R. Brzezinski
Individual Differences in Nicotine Kinetics
and Metabolism in Humans-----48
Neal L. Benowitz and Peyton Jacob III
Inhibitors of Anandamide Breakdown-----65
Dale G. Deutsch and Alexandros Makriyannis
Metabolic Bioactivation Reactions Potentially
Related to Drug Toxicities-----85
Neal Castagnoli, Jr. and Kay P. Castagnoli
The Role of Iminium-Enamine Species in the
Toxication and Detoxication of Cyclic Tertiary Amines-----106
Lawrence M. Sayre, David A. Engelhart, Durgesh V. Nadkarni, M.K. Manoj
Babu, Ann Marie Flammang, and G. David McCoy
Neurotoxicity of Amphetamines and Their Metabolites-----128
James W. Gibb, Michel Johnson, Ikram Elayan, Heng Keang Lim, Lisa Matsuda,
and Glen R. Hanson
Potential New Insights Into the Molecular
Mechanisms of Methamphetamine-Induced Neurodegeneration-----146
Monika Z. Wrona, Zhaoliang Yang, Fa Zhang, and Glenn Dryhurst
Immunotoxicology of Opioids, Inhalants, and
Other Drugs of Abuse-----175
Robert V. House, Peter T. Thomas, and Hemendra N. Bhargava
Inhalation Studies With Drugs of Abuse-----201
Yun Meng, Aron H. Lichtman, D. Troy Bridgen, and Billy R. Martin
Biocatalysts in Detoxication of Drugs of
Abuse-----225
John R. Cashman
Antibodies as Pharmacokinetic and Metabolic
Modifiers of Neurotoxicity-----259
S. Michael Owens
Toxicokinetics in the National Toxicology
Program-----273
Thomas J. Goehl
Ordering Information-----305
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